Inhibition of GNAQ-regulated signaling in uveal melanoma (Homo sapiens)

From WikiPathways

Revision as of 21:27, 27 August 2024 by Khanspers (Talk | contribs)
Jump to: navigation, search
ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Classical signalingpathwayAberrant cell growthSurvivalCancerCell deathTumor regressionPKCFAKFAK inhibitorDarovasertibTEAD1YAP1TEAD2TEAD3TEAD4G-gammaGNAQGPCRG-betaTRIORHOADAGPKN1PKN2PKN3ROCK1PLCB1PLCB2PLCB3PLCB4MAPK1YAP1LATS1LATS2MOB1API3KAKT/mTORNon-canonical signaling pathwayHippo pathwayName: Inhibition of Gαq-regulated signaling in uveal melanomaOrganism: Homo sapiens


Description

draft

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Image:Curated.pngReview changes for Approved

Ontology Terms

Disease : uveal cancer
Cell Type : melanocyte
 

Bibliography

  1. Arang N, Lubrano S, Ceribelli M, Rigiracciolo DC, Saddawi-Konefka R, Faraji F, Ramirez SI, Kim D, Tosto FA, Stevenson E, Zhou Y, Wang Z, Bogomolovas J, Molinolo AA, Swaney DL, Krogan NJ, Yang J, Coma S, Pachter JA, Aplin AE, Alessi DR, Thomas CJ, Gutkind JS; ''High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma.''; Cell Rep Med, 2023 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137747
Approved
view18:17, 7 March 2025Khanspersupdated interactions to graphical lines for labels
137689view05:17, 7 March 2025EgonwModified description
136023view16:36, 8 December 2024EweitzAdd DrugBank ID for darovasertib
136022view16:33, 8 December 2024EweitzEconomize layout
136021view16:29, 8 December 2024EweitzEconomize layout
136020view16:21, 8 December 2024EweitzModified description
136019view16:20, 8 December 2024EweitzModified title
135838view01:37, 16 November 2024KhanspersPKC EC number
135837view01:32, 16 November 2024KhanspersEconomize layout
135836view00:48, 16 November 2024KhanspersPI3K and AKT/mtor
135419view17:47, 5 September 2024Khansperstest
135356view22:28, 27 August 2024KhanspersModified description
135355view22:10, 27 August 2024Khanspersadded mutation and legend
135354view21:51, 27 August 2024KhanspersOntology Term : 'melanocyte' added !
135349view21:38, 27 August 2024KhanspersModified description
135348view21:27, 27 August 2024KhanspersOntology Term : 'G protein mediated signaling pathway' added !
135347view21:27, 27 August 2024KhanspersOntology Term : 'uveal cancer' added !
135346view21:25, 27 August 2024KhanspersModified title
135345view21:23, 27 August 2024KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AKT/mTORGeneProduct
DAGMetaboliteCHEBI:18035 (ChEBI)
DarovasertibMetabolite
FAK inhibitorMetaboliteCHEBI:76617 (ChEBI)
FAKGeneProductPTK2 (HGNC)
G-betaGeneProductIPR016346 (InterPro)
G-gammaGeneProductIPR036284 (InterPro)
GNAQGeneProductGNAQ (HGNC)
LATS1GeneProductLATS1 (HGNC)
LATS2GeneProductLATS2 (HGNC)
MAPK1GeneProductMAPK1 (HGNC)
MOB1AGeneProductMOB1A (HGNC)
PI3KGeneProduct
PKCGeneProduct
PKN1GeneProductPKN1 (HGNC)
PKN2GeneProductPKN2 (HGNC)
PKN3GeneProductPKN3 (HGNC)
PLCB1GeneProductPLCB1 (HGNC)
PLCB2GeneProductPLCB2 (HGNC)
PLCB3GeneProductPLCB3 (HGNC)
PLCB4GeneProductPLCB4 (HGNC)
RHOAGeneProductRHOA (HGNC)
ROCK1GeneProductROCK1 (HGNC)
TEAD1GeneProductTEAD1 (HGNC)
TEAD2GeneProductTEAD2 (HGNC)
TEAD3GeneProductTEAD3 (HGNC)
TEAD4GeneProductTEAD4 (HGNC)
TRIOGeneProductTRIO (HGNC)
YAP1GeneProductYAP1 (HGNC)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5490"
Personal tools