Cell division: first embryonic mitosis (Caenorhabditis elegans)

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Description

"Prior to fertilization, C. elegans oocytes are arrested in meiotic prophase with nuclei containing two copies of the diploid genome packaged into recombined bivalent chromosomes. The two rounds of meiotic chromosome segregation that generate the haploid oocyte pronucleus are completed in the zygote after the oocytes are fertilized. During each meiotic division, chromosome segregation is accomplished by a small acentriolar meiotic spindle that forms in the embryo anterior. During anaphase of meiosis I and again in meiosis II, the meiotic spindle associates with the cortex in an end-on fashion, and a highly asymmetric cytokinesis-like event extrudes a polar body (Figure 2; Albertson and Thomson, 1993; Clark-Maguire and Mains, 1994; Yang et al., 2003). In addition to the haploid pronucleus, the sperm brings a pair of centrioles into the oocyte, which lacks centrioles due to their degradation during oogenesis. As meiosis completes, the haploid oocyte and sperm-derived pronuclei, located at opposite ends of the embryo increase in size, becoming visible by DIC microscopy. After entering the oocyte, the sperm-derived centriole pair recruits pericentriolar material and acquires the ability to nucleate microtubules (O'Connell, 2000; Pelletier et al., 2004). Subsequently, the two sperm-derived centrioles separate, forming two centrosomes positioned on either side of the paternal pronucleus. Coincident with chromosome condensation during mitotic prophase, the pronuclei migrate towards each other. After the pronuclei meet, the nuclear-centrosome complex moves to the center of the embryo and rotates to align with the long axis of the embryo (Albertson, 1984; Hyman and White, 1987). The miotitc spindle begins to move towards the embryo posterior during metaphase (Labbe et al., 2004; Oegema et al., 2001), and asymmetric elongation during anaphase contributes to its posterior displacement (Albertson, 1984; Grill et al., 2001). Since the cleavage furrow bisects the mitotic spindle, this displacement results in an asymmetric first cleavage (For more on the mechanisms that generate this asymmetry see Asymmetric cell division and axis formation in the embryo). " From "Cell division" by Karen Oegema, WormBook

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
135389view12:10, 3 September 2024EgonwUpdated a WormBase id to Ensembl
135363view04:57, 2 September 2024EgonwConverted to use Ensembl identifiers
118330view12:58, 27 May 2021RaatsSfixed unconnected lines and too small labels
117055view14:20, 16 May 2021EweitzModified title
84464view19:09, 25 February 2016AlexanderPicoQuick edit to datanode annotation or property
78455view10:27, 7 January 2015MaintBotadded missing graphIds
75501view21:27, 3 June 2014KyookOntology Term : 'pathway pertinent to DNA replication, cell cycle, DNA repair and maintenance of genomic integrity, RNA and protein biosynthesis' added !
75500view21:26, 3 June 2014KyookOntology Term : 'animal cell' added !
74473view04:17, 25 April 2014EgonwFixed a PubMed ID.
72144view10:05, 25 October 2013Mkutmonadded datasource for NUD-1
70080view09:54, 12 July 2013Mkutmonusing graphical line elements instead of interaction lines
50937view23:15, 24 August 2012KyookOntology Term : 'zygote' added !
40640view19:58, 1 March 2011MaintBotRemoved redundant pathway information and comments
34963view22:50, 8 February 2010KhanspersFixed xrefs
34962view22:44, 8 February 2010KhanspersCleaned up comments
34961view22:42, 8 February 2010KhanspersReverted to version '23:44, 23 December 2009' by Khanspers
34960view22:41, 8 February 2010KhanspersCleaned up comments
34606view23:44, 23 December 2009KyookModified description
34605view23:38, 23 December 2009Kyookremoved extra objects, cleaned up the page a bit
33371view14:35, 30 November 2009MaintBotRemoved group label
33193view18:10, 5 November 2009KhanspersModified categories
32938view21:19, 22 September 2009KyookNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
21ur-13952GeneProductC36E8.9 (WormBase)
  • C36E8.9
  • GO:0035046 WBPaper00025054

    GO:0007052 WBPaper00006305

    GO:0009792 WBPaper00004403; WBPaper00025054; WBPaper00006305; WBPaper00013420
21ur-15150GeneProductK10D11.8 (WormBase)
  • GO:0035046

    GO:0051301

    GO:0000910
  • WBPaper0006352
AIR-1GeneProductK07C11.2 (WormBase)
AIR-1GeneProductWBGene00000098 (Ensembl)
AIR-2GeneProductWBGene00000099 (Ensembl)
ANC-1GeneProductWBGene00000140 (Ensembl)
ANI-1GeneProductWBGene00013038 (Ensembl) GO:0040002

GO:0030865

GO:0009792
ARP-1GeneProductWBGene00013168 (Ensembl) GO:0002009 WBPaper00006395

GO:0002119 WBPaper00006395;WBPaper00024497 GO:0009792 WBPaper00005654;WBPaper00025054;WBPaper00006395 GO:0035046 WBPaper00006060;WBPaper00025054 GO:0040007 WBPaper00006395;WBPaper00024497 GO:0040010 WBPaper00024497

GO:0040011 WBPaper00006395;WBPaper00005654
BEN-1GeneProductWBGene00000248 (Ensembl) GO:0035046 WBPaper00025054

GO:0002009 WBPaper00029258 GO:0040035 WBPaper00029258 GO:0040018 WBPaper00029258 GO:0007635 WBPaper00001228 GO:0040007 WBPaper00029258 GO:0002119 WBPaper00029258

GO:0009792 WBPaper00025054
BIR-1GeneProductWBGene00000249 (Ensembl)
BUB-1GeneProductWBGene00000275 (Ensembl)
BUB-3GeneProductWBGene00013209 (Ensembl)
CAP-2GeneProductWBGene00000293 (Ensembl) GO:0000578 WBPaper00002000

GO:0040010 WBPaper00005654 GO:0035046 WBPaper00006060 GO:0040022 WBPaper00001883 GO:0010171 WBPaper00005654;WBPaper00029258 GO:0040035 WBPaper00029258 GO:0040007 WBPaper00024497;WBPaper00029258 GO:0002119 WBPaper00005654;WBPaper00024497;WBPaper00029258

GO:0009792 WBPaper00005654;WBPaper00025054;WBPaper00024497;WBPaper00029258
CAP-GGeneProductWBGene00010093 (Ensembl)
CLASPGeneProductWBGene00000549 (Ensembl)
CSC-1GeneProductWBGene00000804 (Ensembl)
CUL-3GeneProductWBGene00000838 (Ensembl) GO:0035046 WBPaper00025054

GO:0009792 WBPaper00004651;WBPaper00025054;WBPaper00026821

GO:0044254 WBPaper00026631
CYK-1GeneProductWBGene00000872 (Ensembl) GO:0000003 WBPaper00006395

GO:0002009 WBPaper00005654;WBPaper00006395;WBPaper00029258 GO:0000910 WBPaper00025054 GO:0009792 WBPaper00004403;WBPaper00005654;WBPaper00006395;WBPaper00024497;WBPaper00025054;WBPaper00029258;WBPaper00004509 GO:0008340 WBPaper00005654 GO:0035046 WBPaper00004544 GO:0040011 WBPaper00006395 GO:0040035 WBPaper00029258 GO:0040015 WBPaper00006395 GO:0040007 WBPaper00024497;WBPaper00029258

GO:0002119 WBPaper00024497;WBPaper00029258
CYK-4GeneProductWBGene00000875 (Ensembl)
CZW-1GeneProductWBGene00017643 (Ensembl)
Ce-BAF-1GeneProductWBGene00000235 (Ensembl)
Ce-MAN1/LEM-2GeneProductWBGene00002275 (Ensembl)
Ce-emerin/EMR-1GeneProductM01D7.6 (WormBase)
CeCENP-AGeneProductWBGene00001831 (Ensembl)
CeCENP-CGeneProductWBGene00001832 (Ensembl)
CeGrip-1/GIP-1GeneProductWBGene00001589 (Ensembl)
CeGrip-2/GIP-2GeneProductWBGene00001590 (Ensembl)
CeLamin/LMN-1GeneProductWBGene00003052 (Ensembl)
CeMCAKGeneProductWBGene00002219 (Ensembl)
DHC-1GeneProductWBGene00000962 (Ensembl)
DLC-1GeneProductWBGene00001005 (Ensembl)
DLI-1GeneProductWBGene00001007 (Ensembl)
DNC-1GeneProductWBGene00001017 (Ensembl)
DNC-2GeneProductWBGene00001018 (Ensembl)
DNC-4GeneProductWBGene00016124 (Ensembl)
DYCI-1GeneProductWBGene00015927 (Ensembl)
DYRB-1GeneProductWBGene00012004 (Ensembl)
F54B3.3GeneProductWBGene00010015 (Ensembl)
GPB-1GeneProductWBGene00001679 (Ensembl)
GPC-2GeneProductWBGene00001682 (Ensembl)
HCP-1GeneProductWBGene00001829 (Ensembl)
HCP-2GeneProductWBGene00001830 (Ensembl)
HCP-6GeneProductWBGene00001833 (Ensembl)
HIM-1GeneProductWBGene00001860 (Ensembl)
ICP-1/CeINCENPGeneProductWBGene00002047 (Ensembl)
ICP-1/CeINCEPGeneProductWBGene00002047 (Ensembl)
IMA-2GeneProductWBGene00002073 (Ensembl) GO:0007084
KBP-1GeneProductWBGene00020064 (Ensembl)
KBP-1GeneProductY92C3B.1 (WormBase)
KBP-2GeneProductWBGene00017832 (Ensembl)
KBP-5GeneProductWBGene00016387 (Ensembl)
KLE-2GeneProductWBGene00016202 (Ensembl)
KLP-19GeneProductWBGene00002229 (Ensembl)
KNL-1GeneProductWBGene00002231 (Ensembl)
KNL-2GeneProductWBGene00019432 (Ensembl)
KNL-3GeneProductWBGene00020392 (Ensembl)
LET-21/Ect-2GeneProductWBGene00002297 (Ensembl)
LET-502GeneProductWBGene00002694 (Ensembl)
LET-754GeneProductWBGene00002879 (Ensembl)
LET-92GeneProductWBGene00002363 (Ensembl)
LET-99GeneProductWBGene00002368 (Ensembl)
LIS-1GeneProductWBGene00003047 (Ensembl)
LRG-1GeneProductF55H2.4 (WormBase)
MBK-2GeneProductWBGene00003150 (Ensembl)
MDF-2GeneProductWBGene00003161 (Ensembl)
MEL-11GeneProductWBGene00003196 (Ensembl)
MEL-28GeneProductWBGene00003210 (Ensembl)
MFDF-1GeneProductWBGene00003160 (Ensembl)
MIS-12GeneProductWBGene00021648 (Ensembl)
MIX-1GeneProductWBGene00003367 (Ensembl)
MLC-4GeneProductWBGene00003372 (Ensembl)
Matefin/SUN-1GeneProductWBGene00006311 (Ensembl)
NDC-80GeneProductWBGene00003576 (Ensembl)
NMY-2GeneProductWBGene00003777 (Ensembl)
NUD-1GeneProductWBGene00003829 (Ensembl)
PAR-5GeneProductWBGene00003920 (Ensembl)
PFD-2GeneProductWBGene00019220 (Ensembl)
PFD-3GeneProductWBGene00006889 (Ensembl)
PFD-5GeneProductWBGene00020112 (Ensembl)
PFN-1GeneProductWBGene00003989 (Ensembl)
PLK-1GeneProductWBGene00004042 (Ensembl) GO:0000003

GO:0000003 GO:0007077 GO:0000910 GO:0009792 GO:0008340 GO:0051301 GO:0040035 GO:0040038 GO:0051726 GO:0002119

GO:0045132
PLK-2GeneProductWBGene00004042 (Ensembl) GO:0000003

GO:0000003 GO:0007077 GO:0000910 GO:0009792 GO:0008340 GO:0051301 GO:0040035 GO:0040038 GO:0051726 GO:0002119

GO:0045132
PLL-1GeneProductWBGene00004045 (Ensembl)
PUF-3GeneProductY45F10A.2 (WormBase)
RBX-1GeneProductWBGene00004320 (Ensembl)
RHO-1GeneProductWBGene00004357 (Ensembl)
ROD-1GeneProductWBGene00018900 (Ensembl)
SAN-1GeneProductWBGene00004721 (Ensembl)
SAS-4GeneProductWBGene00004726 (Ensembl)
SAS-5GeneProductWBGene00009385 (Ensembl)
SAS-6GeneProductWBGene00012888 (Ensembl)
SCC-1GeneProductWBGene00004737 (Ensembl)
SCC-3GeneProductWBGene00004738 (Ensembl)
SMC-3GeneProductWBGene00004873 (Ensembl)
SMC-4GeneProductWBGene00004874 (Ensembl)
SPD-1GeneProductWBGene00004952 (Ensembl)
SPD-2GeneProductWBGene00004953 (Ensembl)
SPD-5GeneProductWBGene00004955 (Ensembl)
Spc25/KBP-3GeneProductWBGene00009179 (Ensembl)
T13E8.2GeneProductT13E8.2 (WormBase)
T13E8.3GeneProductT13E8.3 (WormBase)
T16G12.1GeneProductWBGene00011803 (Ensembl)
T26A5.8GeneProductWBGene00020823 (Ensembl)
TAC-1GeneProductY54E2A.3 (WormBase)
TAG-170GeneProductWBGene00006515 (Ensembl)
TBA-1GeneProductF26E4.8 (WormBase)
TBA-2GeneProductC47B2.3 (WormBase)
TBA-4GeneProductWBGene00006530 (Ensembl)
TBB-1GeneProductWBGene00006536 (Ensembl)
TBB-2GeneProductWBGene00006537 (Ensembl)
TIM-1GeneProductWBGene00006571 (Ensembl)
UNC-37GeneProductWBGene00006773 (Ensembl)
UNC-59GeneProductWBGene00006793 (Ensembl)
UNC-60AGeneProductWBGene00302980 (Ensembl)
UNC-61GeneProductWBGene00006795 (Ensembl)
UNC-83GeneProductWBGene00006815 (Ensembl)
UNC-84GeneProductWBGene00006816 (Ensembl)
Y19D2B.1GeneProductY19D2B.1 (WormBase)
Y47D3A.29GeneProductWBGene00012936 (Ensembl)
Y71F9AL.14GeneProductWBGene00022118 (Ensembl)
ZEN-4GeneProductWBGene00006974 (Ensembl)
ZYG-12GeneProductWBGene00006997 (Ensembl)
ZYG-1GeneProductWBGene00006988 (Ensembl)
ZYG-9GeneProductWBGene00006994 (Ensembl)
g-tubulin/TBG-1GeneProductWBGene00006540 (Ensembl)
nuf-2/HIM-10GeneProductWBGene00001869 (Ensembl)

Annotated Interactions

No annotated interactions

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