Sulfide oxidation pathway (Caenorhabditis elegans)
From WikiPathways
Description
"Proposed mechanism. Both H2S and HCN can inhibit electron transport. Electron transport inhibition causes induction of HIF-1 activity resulting in high expression of SQRD-1 and CYSL-2. SQRD-1 catalyzes the first step in the H2S-oxidation pathway, ultimately resulting in production of sulfate and thiosulfate. CYSL-2 catalyzes the first step in the HCN assimilation pathway, producing H2S. The resultant H2S is detoxified by CYSL-1."
Quality Tags
Ontology Terms
Saving...Bibliography
- Budde MW, Roth MB; ''The response of Caenorhabditis elegans to hydrogen sulfide and hydrogen cyanide.''; Genetics, 2011 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| CYSL-1 | GeneProduct | WBGene00007653 (Ensembl)  | |
| CYSL-2 | GeneProduct | WBGene00010759 (Ensembl) | |
| ETHE-1 | GeneProduct | C33A12.7 (WormBase) | |
| H2S | Metabolite | 7783-06-4 (CAS) | |
| HIF-1 | GeneProduct | WBGene00001851 (Ensembl) | |
| O-Acetylserine | Metabolite | 4985-36-8 (CAS) | |
| SQRD-1 | GeneProduct | WBGene00008538 (Ensembl) | |
| acetate | Metabolite | 71-50-1 (CAS) | |
| beta-cyanoalanine | Metabolite | 923-01-3 (CAS) | |
| cysteine | Metabolite | 52-90-4 (CAS) | |
| hydrogen cyanide | Metabolite | 74-90-8 (CAS) | |
| hydrogen cyanide | Metabolite | HMDB0002084 (HMDB) | |
| polysulfide | Metabolite | 9080-49-3 (CAS) | |
| sulfate | Metabolite | HMDB0001448 (HMDB) | |
| thiosulfate | Metabolite | HMDB0000257 (HMDB) |
Annotated Interactions
No annotated interactions
