Histidine biosynthesis (Saccharomyces cerevisiae)

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Description

Histidine is synthesized from phosphoribosyl pyrophosphate (PRPP), which is produced in the pentose phosphate pathway. The first step in the pathway is the condensation of PRPP and ATP by ATP-phosphoribosyl transferase (HIS1). HIS4 then hydrolyzes phosphoribosyl-ATP, which produces phosphoribosyl-AMP (PRAMP). Next, HIS4 catalyzes the formation of phosphoribosylformiminoAICAR-phosphate, which is converted to phosphoribulosylformimino-AICAR-P by the HIS6 gene product. HIS7 splits phosphoribulosylformimino-AICAR-P to form d-erythro-imidazole-glycerol-phosphate. HIS3 forms imidazole acetol-phosphate releasing water. HIS5 then makes l-histidinol-phosphate, which is hydrolyzed by HIS2 making histidinol. HIS4 catalyzes the oxidation of l-histidinol to form l-histidinal. In the last step, l-histidinal is converted to l-histidine. Description adapted from Wikipedia.

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Bibliography

  1. Rébora K, Laloo B, Daignan-Fornier B; ''Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule.''; Genetics, 2005 PubMed Europe PMC Scholia
  2. Alifano P, Fani R, Liò P, Lazcano A, Bazzicalupo M, Carlomagno MS, Bruni CB; ''Histidine biosynthetic pathway and genes: structure, regulation, and evolution.''; Microbiol Rev, 1996 PubMed Europe PMC Scholia
  3. Denis V, Boucherie H, Monribot C, Daignan-Fornier B; ''Role of the myb-like protein bas1p in Saccharomyces cerevisiae: a proteome analysis.''; Mol Microbiol, 1998 PubMed Europe PMC Scholia
  4. ''L-histidine biosynthesis''; YeastPathways,

History

View all...
CompareRevisionActionTimeUserComment
135454view22:16, 5 September 2024KhanspersModified description
135453view22:09, 5 September 2024Khanspers
135452view22:08, 5 September 2024Khanspersadded lit ref
135310view18:53, 16 August 2024KhanspersOntology Term : 'classic metabolic pathway' added !
135309view18:52, 16 August 2024KhanspersModified description
135308view18:52, 16 August 2024Khanspersmetabolite ids, interactions, layout
117300view11:16, 20 May 2021EweitzModified title
93001view18:23, 21 July 2017KhanspersModified description
93000view18:23, 21 July 2017Khanspersremoved GenMAPP notes
92888view09:47, 14 July 2017Jeffrey GoessensFixed some interactions
85639view16:17, 4 June 2016EgonwFixed the CAS number.
71894view10:22, 22 October 2013Mkutmonchanged AICAR to metabolite
70264view21:47, 15 July 2013MaintBotupdated to 2013 schema
69939view20:13, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
67337view10:39, 26 June 2013Christine ChichesterOntology Term : 'histidine biosynthetic pathway' added !
41801view04:48, 2 March 2011MaintBotRemoved redundant pathway information and comments
36660view22:53, 9 April 2010MaintBot
36621view22:32, 9 April 2010MaintBotDescription and bibliography added from SGD
21760view11:32, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Histidine Biosynthesis]] moved to [[Pathway:WP514]]: Moved to stable identifier
12748view08:00, 17 May 2008MaintBotautomated metabolite conversion
8783view14:09, 7 January 2008MaintBotAdded to category $category
8781view14:09, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-oxoglutarateMetaboliteCHEBI:16810 (ChEBI)
AICARMetabolite3031-94-5 (CAS)
ATPMetabolite1927-31-7 (CAS)
D-erythro-imidazole-glycerol-phosphate Metabolite58278 (ChEBI)
H+Metabolite15378 (ChEBI)
H2OMetaboliteHMDB02111 (HMDB)
HIS1GeneProductS000000857 (SGD)
HIS2GeneProductS000001921 (SGD)
HIS3GeneProductS000005728 (SGD)
HIS4GeneProductS000000535 (SGD)
HIS5GeneProductS000001378 (SGD)
HIS6GeneProductS000001282 (SGD)
HIS7GeneProductS000000452 (SGD)
HistidinalMetaboliteHMDB12234 (HMDB)
HistidinolMetaboliteHMDB03431 (HMDB)
L-glutamateMetabolite56-86-0 (CAS)
L-glutamineMetabolite56-85-9 (CAS)
L-histidineMetabolite71-00-1 (CAS)
L-histidinol phosphateMetabolite57980 (ChEBI)
NADMetabolite57540 (ChEBI)
NADHMetabolite53-84-9 (CAS)
PRPPMetabolite97-55-2 (CAS)
Phosphoribosyl-AMPMetaboliteHMDB12276 (HMDB)
Phosphoribosyl-ATPMetaboliteHMDB03665 (HMDB)
Phosphoribosylformimino-AICAR-PhosphateMetabolite58435 (ChEBI)
Phosphoribulosylformimino-AICAR-PMetaboliteHMDB12278 (HMDB)
imidazole acetol-phosphateMetabolite57766 (ChEBI)
phosphateMetabolite14265-44-2 (CAS)
pyrophosphateMetabolite2466-09-3 (CAS)

Annotated Interactions

No annotated interactions

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