Pathways into methionine and folate cycles (Homo sapiens)

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Cobalamin B12, Folate B Riboflavin B2 Pathway into Methionine Cycle & Folate Cycle

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Riboflavin,

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  1. 10.DOI: 10.1080/23312025.2019.1606555; ''''; , DOI Scholia
  2. DOI: 10.1038/s41398-020-0755-4; ''''; , DOI Scholia
  3. DOI: 10.1093/nar/gkab1016 RHEA:15889; ''''; , DOI Scholia
  4. 10.1093/jncics/pkad039; ''''; , DOI Scholia
  5. Luvisetto S, Fellin T, Spagnolo M, Hivert B, Brust PF, Harpold MM, Stauderman KA, Williams ME, Pietrobon D.; ''Modal gating of human CaV2.1 (P/Q-type) calcium channels: I. The slow and the fast gating modes and their modulation by beta subunits.''; PubMed Europe PMC Scholia
  6. doi: 10.20517/jtgg.2020.34; ''''; , DOI Scholia
  7. DOI: 10.1093/ijnp/pyw013; ''''; , DOI Scholia
  8. doi: 10.1515/jpem-2012-0293; ''''; , DOI Scholia
  9. DOI: 10.1016/j.gene.2017.05.003; ''''; , DOI Scholia
  10. Jung CH, Ro SH, Cao J, Otto NM, Kim DH; ''mTOR regulation of autophagy.''; FEBS Lett, 2010 PubMed Europe PMC Scholia
  11. DOI: 10.1186/s12993-015-0080-x; ''''; , DOI Scholia
  12. DOI: 10.1161/01.ATV.0000243924.00970.cb; ''''; , DOI Scholia
  13. Vignali S, Leiss V, Karl R, Hofmann F, Welling A.; ''Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells.''; PubMed Europe PMC Scholia
  14. Zachari M, Ganley IG; ''The mammalian ULK1 complex and autophagy initiation.''; Essays Biochem, 2017 PubMed Europe PMC Scholia
  15. DOI: 10.3390/genes12091407; ''''; , DOI Scholia
  16. https://www.pharmgkb.org/pathway/PA166181002; ''''; ,
  17. DOI: 10.1186/s40246-021-00319-2; ''''; , DOI Scholia
  18. doi: 10.1073/pnas.1002404107; ''''; , DOI Scholia
  19. http://autism.mindspec.org/GeneDetail/NLGN3; ''''; ,
  20. DOI: 10.3389/fpsyt.2021.780921; ''''; , DOI Scholia
  21. Sharp GW.; ''Mechanisms of inhibition of insulin release.''; PubMed Europe PMC Scholia
  22. DOI: 10.3390/nu13093207; ''''; , DOI Scholia
  23. doi: 10.1002/jimd.12060.; ''''; , DOI Scholia
  24. DOI: 10.3390/genes12050782; ''''; , DOI Scholia
  25. DOI: 10.3389/fneur.2021.683275; ''''; , DOI Scholia
  26. DOI: 10.1016/j.tips.2017.04.001; ''''; , DOI Scholia
  27. https://tmedweb.tulane.edu/pharmwiki/doku.php/amphetamines; ''''; ,
  28. DOI: 10.3389/fpsyt.2021.788779; ''''; , DOI Scholia
  29. 10.1136/jmedgenet-2011-100386; ''''; , DOI Scholia
  30. DOI: 10.1186/1471-2105-9-S12-S23; ''''; , DOI Scholia
  31. Froese DS, Zhang J, Healy S, Gravel RA; ''Mechanism of vitamin B12-responsiveness in cblC methylmalonic aciduria with homocystinuria.''; Mol Genet Metab, 2009 PubMed Europe PMC Scholia
  32. Anderson GD, Chan LN; ''Pharmacokinetic Drug Interactions with Tobacco, Cannabinoids and Smoking Cessation Products.''; Clin Pharmacokinet, 2016 PubMed Europe PMC Scholia
  33. DOI: 10.1016/j.pnpbp.2018.01.016; ''''; , DOI Scholia
  34. DOI: 10.3390/ijms23073861; ''''; , DOI Scholia
  35. https://medlineplus.gov/genetics/gene/hcfc1/#synonyms; ''''; ,
  36. Laprairie RB, Bagher AM, Kelly ME, Denovan-Wright EM; ''Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor.''; Br J Pharmacol, 2015 PubMed Europe PMC Scholia
  37. DOI: 10.1038/s41598-017-06782-z; ''''; , DOI Scholia
  38. https://my.clevelandclinic.org/health/treatments/24797-snri; ''''; ,
  39. ; ''''; , DOI Scholia
  40. https://www.omim.org/entry/612100; ''''; ,
  41. doi: 10.1371/journal.pone.0085164; ''''; , DOI Scholia
  42. DOi: 10.3390/ijms23073861; ''''; , DOI Scholia
  43. DOI: 10.1016/j.molmet.2018.01.007; ''''; , DOI Scholia
  44. https://doi.org/10.1177/1362361319868633; ''''; , DOI Scholia
  45. DOI: 10.1016/j.neures.2008.11.007; ''''; , DOI Scholia
  46. Froese DS, Gravel RA; ''Genetic disorders of vitamin B12 metabolism: eight complementation groups--eight genes.''; Expert Rev Mol Med, 2010 PubMed Europe PMC Scholia
  47. Raux E, Schubert HL, Warren MJ; ''Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum.''; Cell Mol Life Sci, 2000 PubMed Europe PMC Scholia
  48. DOI: 10.1038/mp.2013.140; ''''; , DOI Scholia
  49. doi: 10.1093/scan/nsp049; ''''; , DOI Scholia
  50. DOI: 10.1016/j.psychres.2016.10.044; ''''; , DOI Scholia
  51. DOI: 10.1016/j.psychres.2016.10.044; ''''; , DOI Scholia
  52. DOI: 10.1084/jem.20181965; ''''; , DOI Scholia
  53. doi: 10.3390/antiox12051037; ''''; , DOI Scholia
  54. http://autism.mindspec.org/GeneDetail/PTEN; ''''; ,
  55. DOI: https://doi.org/10.3390/ijms21228870; ''''; , DOI Scholia
  56. DOI: 10.1038/nn.4352; ''''; , DOI Scholia
  57. Lang J.; ''Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion.''; PubMed Europe PMC Scholia
  58. DOI: 10.1007/s00702-009-0281-2; ''''; , DOI Scholia
  59. DOI: 10.3389/fphar.2018.00279; ''''; , DOI Scholia
  60. DOI 10.3390/cells10051081; ''''; , DOI Scholia
  61. DOI: 10.3390/cells10051081; ''''; , DOI Scholia
  62. DOI: 10.1039/C4RA09872B; ''''; , DOI Scholia
  63. DOI: 10.1038/tp.2012.7; ''''; , DOI Scholia
  64. DOI: 10.1101/cshperspect.a036780; ''''; , DOI Scholia
  65. ''''; , PubMed Europe PMC Scholia
  66. DOI: https://doi.org/10.1002/iub.114; ''''; , DOI Scholia
  67. ''''; , PubMed Europe PMC Scholia
  68. Lang J, Nishimoto I, Okamoto T, Regazzi R, Kiraly C, Weller U, Wollheim CB.; ''Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits.''; PubMed Europe PMC Scholia
  69. Memmott RM, Dennis PA; ''Akt-dependent and -independent mechanisms of mTOR regulation in cancer.''; Cell Signal, 2009 PubMed Europe PMC Scholia
  70. 10.1016/j.pnpbp.2018.01.013; ''''; , DOI Scholia
  71. DOI: 10.1111/pcn.12606; ''''; , DOI Scholia
  72. DOI: 10.1016/j.psychres.2012.08.016; ''''; , DOI Scholia
  73. https://en.wikipedia.org/wiki/DLG4; ''''; ,
  74. http://autism.mindspec.org/GeneDetail/NLGN4X; ''''; ,
  75. doi: 10.1002/jimd.12060; ''''; , DOI Scholia
  76. DOI: 10.1515/cclm-2012-0673; ''''; , DOI Scholia
  77. DOI: 10.3390/ijms23031910; ''''; , DOI Scholia
  78. DOI: 10.1038/s41430-020-0657-9; ''Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH.''; Biochem Biophys Res Commun, DOI Scholia
  79. Yamada K, Gherasim C, Banerjee R, Koutmos M; ''Structure of Human B12 Trafficking Protein CblD Reveals Molecular Mimicry and Identifies a New Subfamily of Nitro-FMN Reductases.''; J Biol Chem, 2015 PubMed Europe PMC Scholia
  80. Peterhoff M, Sieg A, Brede M, Chao CM, Hein L, Ullrich S.; ''Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice.''; PubMed Europe PMC Scholia
  81. Bratanova-Tochkova TK, Cheng H, Daniel S, Gunawardana S, Liu YJ, Mulvaney-Musa J, Schermerhorn T, Straub SG, Yajima H, Sharp GW.; ''Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion.''; PubMed Europe PMC Scholia
  82. Grabsch H, Pereverzev A, Weiergräber M, Schramm M, Henry M, Vajna R, Beattie RE, Volsen SG, Klöckner U, Hescheler J, Schneider T.; ''Immunohistochemical detection of alpha1E voltage-gated Ca(2+) channel isoforms in cerebellum, INS-1 cells, and neuroendocrine cells of the digestive system.''; PubMed Europe PMC Scholia
  83. 10.1097/YPG.0000000000000010; ''''; , DOI Scholia
  84. 10.1007/7854_2011_187; ''''; , DOI Scholia
  85. DOI: 10.1038/s41392-022-01081-0; ''''; , DOI Scholia
  86. DOI: 10.1016/j.biopha.2020.110496; ''''; , DOI Scholia
  87. ''''; , PubMed Europe PMC Scholia
  88. DOI: 10.1038/mp.2017.255; ''''; , DOI Scholia
  89. DOI: 10.3390/ijms19082439; ''''; , DOI Scholia
  90. https://imfar.confex.com/imfar/2008/webprogram/Paper2290.html; ''''; ,
  91. 10.3389/fmicb.2019.02305; ''''; , DOI Scholia
  92. DOI: 10.1016/j.cell.2010.05.024; ''''; , DOI Scholia
  93. Liu M, Wang X, Wang L, Ma X, Gong Z, Zhang S, Li Y; ''Targeting the IDO1 pathway in cancer: from bench to bedside.''; J Hematol Oncol, 2018 PubMed Europe PMC Scholia
  94. DOI: 10.3389/fphar.2021.740996; ''''; , DOI Scholia
  95. DOI: 10.1186/2040-2392-2-8; ''''; , DOI Scholia
  96. 10.1371/journal.pone.0053727; ''''; , DOI Scholia
  97. Cheng H, Straub SG, Sharp GW.; ''Protein acylation in the inhibition of insulin secretion by norepinephrine, somatostatin, galanin, and PGE2.''; PubMed Europe PMC Scholia
  98. Aylett CH, Sauer E, Imseng S, Boehringer D, Hall MN, Ban N, Maier T; ''Architecture of human mTOR complex 1.''; Science, 2016 PubMed Europe PMC Scholia
  99. DOI: 10.1093/nar/gkab1016 RHEA:15889 RHEA:36683; ''''; , DOI Scholia
  100. DOI: 10.1016/j.neubiorev.2017.01.013; ''''; , DOI Scholia
  101. https://psychscenehub.com/psychinsights/guanfacine-and-clonidine-for-adhd/; ''''; ,
  102. DOI: 10.3389/fnmol.2022.922840; ''''; , DOI Scholia
  103. 10.1007/s00213-009-1628-y; ''''; , DOI Scholia
  104. Lawler NG, Gray N, Kimhofer T, Boughton B, Gay M, Yang R, Morillon AC, Chin ST, Ryan M, Begum S, Bong SH, Coudert JD, Edgar D, Raby E, Pettersson S, Richards T, Holmes E, Whiley L, Nicholson JK; ''Systemic Perturbations in Amine and Kynurenine Metabolism Associated with Acute SARS-CoV-2 Infection and Inflammatory Cytokine Responses.''; J Proteome Res, 2021 PubMed Europe PMC Scholia
  105. DOI: 10.1007/s12519-023-00702-0; ''''; , DOI Scholia
  106. DOI: 10.1021/BI992997S; ''''; , DOI Scholia
  107. DOI: 10.1038/s41598-021-03885-6; ''''; , DOI Scholia
  108. DOI: 10.1172/JCI121277; ''''; , DOI Scholia
  109. ''Assessment of Methylphenidate and Propranolol Combination Treatment in Comparison with Methylphenidate and Placebo Among Children with Attention Deficit Hyperactivity Disorder (ADHD)''; Scientific Medical Journal, 2011
  110. Doi: 10.3390/antiox12051037; ''''; , DOI Scholia
  111. DOI: 10.1016/S0003-9861(03)00295-9; ''''; , DOI Scholia
  112. Barg S, Eliasson L, Renström E, Rorsman P.; ''A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.''; PubMed Europe PMC Scholia
  113. DOI 10.3390/nu8020068; ''Defects of glucose-6-phosphate and 6-phosphogluconate dehydrogenases in Neurospora and their pleiotropic effects.''; Curr Top Cell Regul, 1976 DOI Scholia
  114. Ostenson CG, Gaisano H, Sheu L, Tibell A, Bartfai T.; ''Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients.''; PubMed Europe PMC Scholia
  115. Polson HE, de Lartigue J, Rigden DJ, Reedijk M, Urbe S, Clague MJ, Tooze SA; ''Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation.''; Autophagy, 2010 PubMed Europe PMC Scholia
  116. DOI: 10.1038/s41531-021-00161-2; ''''; , DOI Scholia
  117. 10.1016/j.euroneuro.2012.07.003; ''''; , DOI Scholia
  118. Barg S, Rorsman P.; ''Insulin secretion: a high-affinity Ca2+ sensor after all?''; PubMed Europe PMC Scholia
  119. Huang J, Manning BD; ''The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.''; Biochem J, 2008 PubMed Europe PMC Scholia
  120. Raybaud A, Baspinar EE, Dionne F, Dodier Y, Sauvé R, Parent L.; ''The role of distal S6 hydrophobic residues in the voltage-dependent gating of CaV2.3 channels.''; PubMed Europe PMC Scholia
  121. MacDonald PE, Wang G, Tsuk S, Dodo C, Kang Y, Tang L, Wheeler MB, Cattral MS, Lakey JR, Salapatek AM, Lotan I, Gaisano HY.; ''Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus.''; PubMed Europe PMC Scholia
  122. Watkins D, Rosenblatt DS; ''Inborn errors of cobalamin absorption and metabolism.''; Am J Med Genet C Semin Med Genet, 2011 PubMed Europe PMC Scholia
  123. DOI: 10.1038/s41430-022-01110-9.; ''''; , DOI Scholia
  124. DOI: 10.3389/fpsyt.2022.904091; ''''; , DOI Scholia
  125. https://www.genome.jp/pathway/hsa04150; ''''; ,
  126. Olson CO, Pejhan S, Kroft D, Sheikholeslami K, Fuss D, Buist M, Ali Sher A, Del Bigio MR, Sztainberg Y, Siu VM, Ang LC, Sabourin-Felix M, Moss T, Rastegar M; ''MECP2 Mutation Interrupts Nucleolin-mTOR-P70S6K Signaling in Rett Syndrome Patients.''; Front Genet, 2018 PubMed Europe PMC Scholia
  127. DOI: 10.1089/ars.2012.4641; ''''; , PubMed Europe PMC Scholia
  128. DOI: 10.1111/j.1600-079X.2011.00902.x; ''''; , DOI Scholia
  129. https://www.potomacpsychiatry.com/blog/adra2a-gene-test-adhd-genetic-testing; ''''; ,
  130. Sher E, Giovannini F, Codignola A, Passafaro M, Giorgi-Rossi P, Volsen S, Craig P, Davalli A, Carrera P.; ''Voltage-operated calcium channel heterogeneity in pancreatic beta cells: physiopathological implications.''; PubMed Europe PMC Scholia
  131. doi: 10.1016/B978-0-12-801238-3.64985-1; ''''; , DOI Scholia
  132. DOI: 10.1089/gtmb.2014.0066; ''''; , DOI Scholia
  133. DOI: 10.3390/cells11233815; ''''; , DOI Scholia
  134. ''''; , PubMed Europe PMC Scholia
  135. DOI: 10.3390/cells12071087; ''''; , DOI Scholia
  136. Yang SN, Berggren PO.; ''Beta-cell CaV channel regulation in physiology and pathophysiology.''; PubMed Europe PMC Scholia
  137. Roach PJ; ''AMPK -> ULK1 -> autophagy.''; Mol Cell Biol, 2011 PubMed Europe PMC Scholia
  138. doi: 10.1016/j.bbadis.2016.10.016; ''''; , DOI Scholia
  139. doi: 10.1007/s13311-021-01043-4; ''''; , DOI Scholia
  140. DOI: 10.1186/2040-2392-3-10; ''''; , DOI Scholia
  141. Rutter GA, Hill EV.; ''Insulin vesicle release: walk, kiss, pause ... then run.''; PubMed Europe PMC Scholia
  142. doi: 10.1080/10409238.2021.1979459; ''''; , DOI Scholia
  143. DOI: 10.1016/j.pneurobio.2020.101906; ''''; , DOI Scholia
  144. Su, H, Lenardo, M.; ''Chapter 5 Combined Immune Deficiencies''; https://doi.org/10.1016/B978-0-12-405546-9.00005-4, 2014 DOI Scholia
  145. Tsuboi T, Rutter GA.; ''Insulin secretion by 'kiss-and-run' exocytosis in clonal pancreatic islet beta-cells.''; PubMed Europe PMC Scholia
  146. Wolthers KR, Lou X, Toogood HS, Leys D, Scrutton NS; ''Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry.''; Biochemistry, 2007 PubMed Europe PMC Scholia
  147. doi: 10.1159/000142363; ''''; , DOI Scholia
  148. doi: 10.1590/2326-4594-jiems-2019-0007; ''''; , DOI Scholia
  149. DOI: 10.1016/j.biopsych.2013.03.027; ''''; , DOI Scholia
  150. https://www.pharmgkb.org/pathway/PA166181140; ''''; ,
  151. Bakula D, Muller AJ, Zuleger T, Takacs Z, Franz-Wachtel M, Thost AK, Brigger D, Tschan MP, Frickey T, Robenek H, Macek B, Proikas-Cezanne T; ''WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.''; Nat Commun, 2017 PubMed Europe PMC Scholia
  152. 10.1161/hc3801.095585; ''''; , DOI Scholia
  153. DOI: 10.1038/s12276-017-0018-5; ''''; , DOI Scholia
  154. Funderburk SF, Wang QJ, Yue Z; ''The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond.''; Trends Cell Biol, 2010 PubMed Europe PMC Scholia
  155. https://doi.org/10.3390/ijms21228870; ''''; , DOI Scholia
  156. ''Serum microRNA-501-3p is a potential diagnostic tool for detecting mild cognitive impairment: Ehime genome study.''; J Neurochem, 2023 PubMed Europe PMC Scholia
  157. DOI: 10.1073/pnas.1002404107; ''''; , DOI Scholia
  158. DOI 10.3390/nu8020068; ''''; , DOI Scholia
  159. DOI: https://doi.org/10.3390/children10101639; ''''; , DOI Scholia
  160. DOI: 10.17116/jnevro2021121041151; ''''; , DOI Scholia
  161. Jeon SM; ''Regulation and function of AMPK in physiology and diseases.''; Exp Mol Med, 2016 PubMed Europe PMC Scholia
  162. DOI: 10.3390/ijms21155310; ''''; , DOI Scholia
  163. DOI: 10.1016/S1075-6280(01)27007-4; ''''; , DOI Scholia
  164. PMID: 10.1016/j.biopsych.2013.03.027; ''''; , DOI Scholia
  165. https://magazine.medlineplus.gov/pdf/Common-antidepressants.PDF_.Final_.09012023.pdf; ''''; ,
  166. DOI: 10.1016/j.jphs.2022.08.00; ''A comparison of the substrate specificities of endo-beta-N-acetylglucosaminidases from Streptomyces griseus and Diplococcus Pneumoniae.''; Biochem Biophys Res Commun, 1975 DOI Scholia
  167. DOI: 10.1016/j.nbd.2020.105061; ''''; , PubMed Europe PMC Scholia
  168. 10.1097/MD.0000000000027858; ''''; , DOI Scholia
  169. DOI: 10.15586/codonpublications.parkinsonsdisease.2018.ch7; ''''; , DOI Scholia
  170. 10.3109/08039488.2015.1089321; ''''; , DOI Scholia
  171. 10.DOI: 10.1080/1028415X.2019.1570442; ''''; , DOI Scholia
  172. ''''; , PubMed Europe PMC Scholia
  173. Jiang R, Yamaori S, Takeda S, Yamamoto I, Watanabe K; ''Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes.''; Life Sci, 2011 PubMed Europe PMC Scholia
  174. Zhao Y, Fang Q, Straub SG, Sharp GW.; ''Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel.''; PubMed Europe PMC Scholia
  175. 10.3389/fnmol.2022.919773; ''''; , DOI Scholia
  176. 10.1038/sj.mp.4002090; ''''; , DOI Scholia
  177. Yip CK, Murata K, Walz T, Sabatini DM, Kang SA; ''Structure of the human mTOR complex I and its implications for rapamycin inhibition.''; Mol Cell, 2010 PubMed Europe PMC Scholia
  178. https://hmdb.ca/proteins/HMDBP00295; ''''; ,
  179. DOI: 10.3389/fpls.2021.668819; ''''; , DOI Scholia
  180. 10.1038/sj.mp.4002016; ''''; , DOI Scholia
  181. DOI: 10.4137/IJTR.S8158; ''''; , DOI Scholia
  182. ''''; , PubMed Europe PMC Scholia
  183. Carrier EJ, Auchampach JA, Hillard CJ; ''Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  184. Seino S, Chen L, Seino M, Blondel O, Takeda J, Johnson JH, Bell GI.; ''Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells.''; PubMed Europe PMC Scholia
  185. Catena V, Fanciulli M; ''Deptor: not only a mTOR inhibitor.''; J Exp Clin Cancer Res, 2017 PubMed Europe PMC Scholia
  186. 10.4088/JCP.14l09346; ''''; , DOI Scholia
  187. ''''; , PubMed Europe PMC Scholia
  188. DOI: 10.1016/j.euroneuro.2012.07.003; ''''; , DOI Scholia
  189. 10.31887/DCNS.2012.14.3/jneul; ''''; , DOI Scholia
  190. DOI: 10.1590/2326-4594-jiems-2019-0007; ''''; , DOI Scholia
  191. https://www.genome.jp/pathway/map04921+K04229; ''''; ,
  192. DOI: 10.1016/j.phrs.2022.106340; ''''; , DOI Scholia
  193. DOI: 10.1111/cge.13243; ''''; , DOI Scholia
  194. DOI: 10.3389/fphar.2019.00452; ''''; , DOI Scholia
  195. http://autism.mindspec.org/GeneDetail/SHANK2; ''''; ,
  196. doi: 10.1038/s41398-019-0588-1; ''''; , DOI Scholia
  197. DOI: 10.1038/nature12630; ''''; , DOI Scholia
  198. Winzell MS, Ahrén B.; ''G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes.''; PubMed Europe PMC Scholia
  199. DOI: 10.3389/fendo.2019.00249; ''''; , DOI Scholia
  200. DOI: 10.1176/appi.ajp.161.4.662; ''Circadian variations of hormonal content in the nervous system of the crayfish.''; Comp Biochem Physiol A Comp Physiol, 1975 DOI Scholia
  201. ; ''''; http://www.genecards.org/cgi-bin/carddisp.pl?gene=CNR2&keywords=cnr2,
  202. rs1801394; ''''; ,
  203. DOI: 10.3389/fgene.2018.00635; ''''; , DOI Scholia
  204. 10.1111/j.1601-183X.2007.00384.x; ''''; , DOI Scholia
  205. DOI: 10.1038/ng1136; ''''; , DOI Scholia
  206. Henquin JC, Ishiyama N, Nenquin M, Ravier MA, Jonas JC.; ''Signals and pools underlying biphasic insulin secretion.''; PubMed Europe PMC Scholia
  207. DOI: 10.1371/journal.pone.0051330; ''''; , DOI Scholia
  208. Yang SN, Berggren PO.; ''The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology.''; PubMed Europe PMC Scholia
  209. Cochrane, L., Conroy, Judith, Tansey, Katherine, Gill, Michael, Anney, R., Gallagher, Louise, https://imfar.confex.com/imfar/2008/webprogram/Paper2290.html; ''Genes Analysed for Association with Autism and DBH Level''; Conference: International Meeting for Autism Research 2008, 2008/05/16
  210. 10.1002/ajmg.b.30872; ''''; , DOI Scholia
  211. Ross D, Joyner WL.; ''Resting distribution and stimulated translocation of protein kinase C isoforms alpha, epsilon and zeta in response to bradykinin and TNF in human endothelial cells.''; PubMed Europe PMC Scholia
  212. Gerber SH, Südhof TC.; ''Molecular determinants of regulated exocytosis.''; PubMed Europe PMC Scholia
  213. Díaz-Alonso J, Guzmán M, Galve-Roperh I; ''Endocannabinoids via CB� receptors act as neurogenic niche cues during cortical development.''; Philos Trans R Soc Lond B Biol Sci, 2012 PubMed Europe PMC Scholia
  214. Yajima H, Komatsu M, Sato Y, Yamada S, Yamauchi K, Sharp GW, Aizawa T, Hashizume K.; ''Norepinephrine inhibits glucose-stimulated, Ca2+-independent insulin release independently from its action on adenylyl cyclase.''; , PubMed Europe PMC Scholia
  215. doi: 10.1124/jpet.105.085282.; ''''; , DOI Scholia

History

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CompareRevisionActionTimeUserComment
135731view22:46, 31 October 2024AlexanderPicoremoved stray comment
135730view22:46, 31 October 2024AlexanderPicoModified title
135729view22:46, 31 October 2024AlexanderPicoModified description
135487view00:00, 20 September 2024EweitzModified title
135340view23:25, 26 August 2024Alexmadsen1New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
10-formyl-THFMetaboliteCHEBI:15637 (ChEBI)
5, 10-MTHFPGMetaboliteCHEBI:60976 (ChEBI)
5-10MeTHFMetaboliteCHEBI:20502 (ChEBI)
5-MTHFMetaboliteCHEBI:15641 (ChEBI)
ABCD4ProteinO14678 (Uniprot-TrEMBL) cblJ
AHCYProteinP23526 (Uniprot-TrEMBL)
ALDH1L2ProteinQ3SY69 (Uniprot-TrEMBL)
ALPIProteinP09923 (Uniprot-TrEMBL) Intestinal-type alkaline phosphatase
ALPLProteinP05186 (Uniprot-TrEMBL)
AMNProteinQ9BXJ7 (Uniprot-TrEMBL) aka amnionless
AOX1ProteinQ06278 (Uniprot-TrEMBL) Aldehyde oxidase
AdoCblMetaboliteCHEBI:18408 (ChEBI)
B2MetaboliteCHEBI:17015 (ChEBI)
B9MetaboliteCHEBI:27470 (ChEBI)
BHMTProteinQ93088 (Uniprot-TrEMBL)
CBLIFProteinP27352 (Uniprot-TrEMBL)
  • aka (gastric) intrinsic factor, transcobalamin III
  • Located in gastric parietal cells
CBSProteinP35520 (Uniprot-TrEMBL)
CD320ProteinQ9NPF0 (Uniprot-TrEMBL) Aka CD320 receptor
CUBNProteinO60494 (Uniprot-TrEMBL) aka cubilin
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CblMetaboliteCHEBI:23334 (ChEBI)
DHFMetaboliteCHEBI:23743 (ChEBI)
DHFRProteinP00374 (Uniprot-TrEMBL)
DNMT1ProteinP26358 (Uniprot-TrEMBL)
FADMetaboliteCHEBI:57692 (ChEBI) cofactor
FLAD1MetaboliteQ8NFF5 (ChEBI)
FMNMetabolitecHEBI:58210 (ChEBI)
FOLH1GeneProductQ04609 (Uniprot-TrEMBL)
FOLR1ProteinP15328 (Uniprot-TrEMBL)
FOLR2ProteinP14207 (Uniprot-TrEMBL)
GNMTProteinQ14749 (Uniprot-TrEMBL)
HCFC1 (cblX)GeneProductP51610 (Uniprot-TrEMBL)
LMBRD1ProteinQ9NUN5 (Uniprot-TrEMBL) cblF
MAT1AProteinQ00266 (Uniprot-TrEMBL)
MAT2BProteinQ9NZL9 (Uniprot-TrEMBL)
MMAAProteinQ8IVH4 (Uniprot-TrEMBL) cbLA
MMABProtein60488 (Uniprot-TrEMBL) cblB
MMACHCProteinQ9Y4U1 (Uniprot-TrEMBL) cbLC
MMADHCProteinQ9H3L0 (Uniprot-TrEMBL)
  • "cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891
  • gene is called MMADHC
MMUTProteinP22033 (Uniprot-TrEMBL) aka methylmalonyl-CoA mutase or MCM
MTHFD1ProteinP11586 (Uniprot-TrEMBL)
MTHFRProteinP42898 (Uniprot-TrEMBL)
MTRProteinQ99707 (Uniprot-TrEMBL)
MTRRProteinQ9UBK8 (Uniprot-TrEMBL)
MeCbl(III)alaminMetaboliteCHEBI:28115 (ChEBI)
MetMetaboliteCHEBI:64558 (ChEBI)
Methylmalonyl-CoAMetaboliteCHEBI:16625 (ChEBI)
Mg2+MetaboliteCHEBI:18420 (ChEBI)
Mo-MPTMetaboliteCHEBI:71302 (ChEBI) Mo-molybdopterin
NGLY1ProteinQ96IV0 (Uniprot-TrEMBL) PNG hydrolase, PNGH
PAMetaboliteCHEBI:17405 (ChEBI) 4-pyridoxic acid
PDXKProteinO00764 (Uniprot-TrEMBL)
PLMetaboliteCHEBI:17310 (ChEBI) pyridoxal
PLPMetaboliteCHEBI:597326 (ChEBI) pyridoxal 5'-phosphate
PMMetaboliteCHEBI:57761 (ChEBI) pyridoxamine
PMPMetaboliteCHEBI:18335 (ChEBI) pyridoxamine 5'-phosphate
PNMetaboliteCHEBI:28803 (ChEBI) pyridoxine, vitamin B6
PNGMetaboliteCHEBI:17382 (ChEBI) pyridoxine-5′-β-D-glucoside
PNPMetaboliteCHEBI:28803 (ChEBI) pyridoxine 5′-phosphate
PNPOProteinQ9NVS9 (Uniprot-TrEMBL)
R-cob(III)alaminMetaboliteCHEBI:140785 (ChEBI)
RFKProteinQ969G6 (Uniprot-TrEMBL)
SAHMetaboliteCHEBI:16680 (ChEBI)
SAMe MetaboliteCHEBI:59789 (ChEBI)
SHMT1ProteinP34896 (Uniprot-TrEMBL)
SLC19A1ProteinP41440 (Uniprot-TrEMBL)
SLC46A1ProteinQ96NT5 (Uniprot-TrEMBL)
SLC52A1GeneProductQ9NWF4 (Uniprot-TrEMBL)
SLC52A2GeneProductQ9HAB3 (Uniprot-TrEMBL)
SLC52A3GeneProductQ9NQ40 (Uniprot-TrEMBL)
SLC?Protein
Succinyl-CoAMetaboliteCHEBI:15380 (ChEBI)
TCN1ProteinP20061 (Uniprot-TrEMBL)
  • aka haptocorrin or transcobalamin 1
  • Produced in saliva and stomach
TCN2ProteinP20062 (Uniprot-TrEMBL) aka Transcobalamin 2
THF-polyglutamateMetaboliteCHEBI:28624 (ChEBI)
THFMetaboliteCHEBI:26907 (ChEBI)
TYMSProteinP04818 (Uniprot-TrEMBL)
Zn2+MetaboliteCHEBI:29105 (ChEBI)
acetateMetaboliteCHEBI:58251 (ChEBI)
cbLA MMAAProteinQ8IVH4 (Uniprot-TrEMBL) Gene: MMAA
cob(I)alaminMetaboliteCHEBI:15982 (ChEBI)
cob(II)alaminMetaboliteCHEBI:16304 (ChEBI) Should be cob(II)alamin according to literature
cobalamins MetaboliteCHEBI:23334 (ChEBI)
cystathionineMetaboliteCHEBI:58161 (ChEBI)
glycine betaineMetaboliteCHEBI:17750 (ChEBI)
glycineMetaboliteCHEBI:57305 (ChEBI)
homocysteineMetaboliteCHEBI:58199 (ChEBI)
hydroxocobalaminMetaboliteCHEBI:27786 (ChEBI)
sarcosineMetaboliteCHEBI:57433 (ChEBI)
serineMetaboliteQ82980657 (Wikidata)
vitamin B12Metabolite
vitamin B6MetaboliteCHEBI:27306 (ChEBI)

Annotated Interactions

SourceTargetTypeDatabase referenceComment
SAMe SAHmim-conversion13681 (Rhea) a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine
SAMe SAHmim-conversion19937 (Rhea) glycine + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + sarcosine
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5488"
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