Hallmark of cancer: non-mutational epigenetic reprogramming (Homo sapiens)

From WikiPathways

Revision as of 19:34, 23 September 2024 by Khanspers (Talk | contribs)
Jump to: navigation, search
ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Maintains methylated DNA-state during replicationRibosomeMETTL3FTOALKBH5YTHDF2HDAC1HDAC2YTHDF1DNMT1YTHDC1AdenosineDNMT3ADNMT3BMETTL14EP300CREBPTET1TET3TET2Mm6Apre-mRNAAdenosineMm6AmRNAYTHDF3CpGs in DNAMCpGs in DNAH2/3/4AH2/3/4EZH2MH2/3/4Name: Hallmark of cancer: non-mutational epigenetic reprogrammingOrganism: Homo sapiens


Description

Hallmarks of Cancer: Nonmutational epigenetical programming

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Image:Curated.pngReview changes for Approved

Ontology Terms

 

Bibliography

View all...
  1. Wang JY, Lu AQ; ''The biological function of m6A reader YTHDF2 and its role in human disease.''; Cancer Cell Int, 2021 PubMed Europe PMC Scholia
  2. Schöller E, Weichmann F, Treiber T, Ringle S, Treiber N, Flatley A, Feederle R, Bruckmann A, Meister G; ''Interactions, localization, and phosphorylation of the m(6)A generating METTL3-METTL14-WTAP complex.''; RNA, 2018 PubMed Europe PMC Scholia
  3. Durbin AD, Wang T, Wimalasena VK, Zimmerman MW, Li D, Dharia NV, Mariani L, Shendy NAM, Nance S, Patel AG, Shao Y, Mundada M, Maxham L, Park PMC, Sigua LH, Morita K, Conway AS, Robichaud AL, Perez-Atayde AR, Bikowitz MJ, Quinn TR, Wiest O, Easton J, Schönbrunn E, Bulyk ML, Abraham BJ, Stegmaier K, Look AT, Qi J; ''EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma.''; Cancer Discov, 2022 PubMed Europe PMC Scholia
  4. Tsiouplis NJ, Bailey DW, Chiou LF, Wissink FJ, Tsagaratou A; ''TET-Mediated Epigenetic Regulation in Immune Cell Development and Disease.''; Front Cell Dev Biol, 2020 PubMed Europe PMC Scholia
  5. Farooqi AA, Fayyaz S, Poltronieri P, Calin G, Mallardo M; ''Epigenetic deregulation in cancer: Enzyme players and non-coding RNAs.''; Semin Cancer Biol, 2022 PubMed Europe PMC Scholia
  6. Yan H, Zhang L, Cui X, Zheng S, Li R; ''Roles and mechanisms of the m(6)A reader YTHDC1 in biological processes and diseases.''; Cell Death Discov, 2022 PubMed Europe PMC Scholia
  7. Chen Z, Zhong X, Xia M, Zhong J; ''The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases.''; Mol Ther Nucleic Acids, 2021 PubMed Europe PMC Scholia
  8. Relier S, Ripoll J, Guillorit H, Amalric A, Achour C, Boissière F, Vialaret J, Attina A, Debart F, Choquet A, Macari F, Marchand V, Motorin Y, Samalin E, Vasseur JJ, Pannequin J, Aguilo F, Lopez-Crapez E, Hirtz C, Rivals E, Bastide A, David A; ''FTO-mediated cytoplasmic m(6)A(m) demethylation adjusts stem-like properties in colorectal cancer cell.''; Nat Commun, 2021 PubMed Europe PMC Scholia
  9. Shi H, Wang X, Lu Z, Zhao BS, Ma H, Hsu PJ, Liu C, He C; ''YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA.''; Cell Res, 2017 PubMed Europe PMC Scholia
  10. Zhang J, Yang C, Wu C, Cui W, Wang L; ''DNA Methyltransferases in Cancer: Biology, Paradox, Aberrations, and Targeted Therapy.''; Cancers (Basel), 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135760
Approved
view12:07, 9 November 2024EgonwRemoved template comments
135542view19:36, 23 September 2024KhanspersOntology Term : 'regulatory pathway' added !
135541view19:34, 23 September 2024KhanspersOntology Term : 'cancer pathway' added !
134339view13:45, 20 July 2024EweitzRefine comment, remove template comment
134338view13:43, 20 July 2024EweitzModified title
133255view09:45, 10 June 2024PhilipErnst
133254view09:44, 10 June 2024PhilipErnstNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ALKBH5ProteinENSG00000150867 (Ensembl)
Adenosine In RRACH domain
CREBPProteinENSG00000005339 (Ensembl)
CpGs in DNA
DNMT1ProteinENSG00000130816 (Ensembl)
DNMT3AProteinENSG00000119772 (Ensembl)
DNMT3BProteinENSG00000142089 (Ensembl)
EP300ProteinENSG00000100393 (Ensembl)
EZH2ProteinENSG00000106462 (Ensembl)
FTO ProteinENSG00000140718 (Ensembl)
H2/3/4
HDAC1ProteinENSG00000116478 (Ensembl)
HDAC2ProteinENSG00000196591 (Ensembl)
METTL14ProteinENSG00000167741 (Ensembl)
METTL3ProteinNSG00000083838 (Ensembl)
TET1ProteinENSG00000168769 (Ensembl)
TET2ProteinENSG00000168769 (Ensembl)
TET3ProteinENSG00000182985 (Ensembl)
YTHDC1ProteinENSG00000169047 (Ensembl)
YTHDF1ProteinENSG00000162408 (Ensembl)
YTHDF2ProteinENSG00000118454 (Ensembl)
  • YTHDF2 binds to m6A regions to promote degradation of mRNA
  • Type your comment here
YTHDF3ProteinENSG00000185728 (Ensembl)
  • YTHDF2 binds to m6A regions to promote degradation of mRNA
  • Type your comment here
m6A
mRNA
pre-mRNA
  • RRACH Domain
  • Type your comment here

Annotated Interactions

No annotated interactions

Personal tools