Isoleucine biosynthesis (Saccharomyces cerevisiae)

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Description

The pathway of L-isoleucine biosynthesis from L-threonine is a five-step pathway that shares several steps with the pathway of L-valine biosynthesis (https://www.wikipathways.org/pathways/WP2.html). These entwined pathways are part of the superpathway of branched chain amino acid biosynthesis, that generates not only L-isoleucine and L-valine, but also L-leucine. Source: BioCyc https://biocyc.org/graphics2021/BioCyc.svg

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Quality Tags

Ontology Terms

 

Bibliography

  1. ''L-isoleucine biosynthesis I (from threonine)''; YeastPathways,
  2. Holmberg S, Petersen JG; ''Regulation of isoleucine-valine biosynthesis in Saccharomyces cerevisiae.''; Curr Genet, 1988 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135553view22:43, 23 September 2024Khanspersreference
135552view22:41, 23 September 2024Khanspersupdated reference
135551view22:39, 23 September 2024KhanspersModified description
135550view22:33, 23 September 2024KhanspersModified description
135549view22:22, 23 September 2024Khanspersupdated interaction type (mim-conversion), updated interaction style, economize layout
135459view22:28, 5 September 2024Khansperslit ref
135458view22:27, 5 September 2024KhanspersModified description
135303view22:56, 15 August 2024KhanspersOntology Term : 'classic metabolic pathway' added !
135302view22:54, 15 August 2024Khanspersremove GenMAPP remark
135301view22:53, 15 August 2024Khansperslayout
135300view22:52, 15 August 2024Khanspersfix interactions, add metabolite ids, cleanup
117307view11:18, 20 May 2021EweitzModified title
89690view10:08, 26 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
69831view14:53, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69651view20:38, 8 July 2013MaintBotUpdated to 2013 gpml schema
67416view10:58, 26 June 2013DdiglesOntology Term : 'isoleucine biosynthetic pathway' added !
41890view04:53, 2 March 2011MaintBotRemoved redundant pathway information and comments
36616view22:31, 9 April 2010MaintBotDescription and bibliography added from SGD
21205view11:31, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Isoleucine Biosynthesis]] moved to [[Pathway:WP250]]: Moved to stable identifier
12752view08:01, 17 May 2008MaintBotautomated metabolite conversion
8789view14:09, 7 January 2008MaintBotAdded to category $category
8787view14:09, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2,3-Dihydroxy-3-methylvalerateMetaboliteCHEBI:882 (ChEBI)
2-Aceto-2-hydroxybutyrateMetabolite21 (PubChem-compound)
2-keto-3-methylvalerateMetaboliteCHEBI:28654 (ChEBI)
2-oxobutanoateMetaboliteCHEBI:16763 (ChEBI)
2-oxoglutarateMetaboliteCHEBI:16810 (ChEBI)
BAT1GeneProductS000001251 (SGD)
BAT2GeneProductS000003909 (SGD)
CO2MetaboliteCHEBI:16526 (ChEBI)
H+MetaboliteHMDB59597 (HMDB)
H2OMetaboliteHMDB02111 (HMDB)
ILV1GeneProductS000000888 (SGD)
ILV2GeneProductS000004714 (SGD)
ILV3GeneProductS000003777 (SGD)
ILV5GeneProductS000004347 (SGD)
ILV6GeneProductS000000515 (SGD)
L-glutamateMetabolite56-86-0 (CAS)
L-isoleucineMetaboliteCHEBI:58045 (ChEBI)
L-threonineMetabolite72-19-5 (CAS)
NADPMetaboliteCHEBI:44409 (ChEBI)
NADPHMetabolite53-57-6 (CAS)
NH3MetaboliteHMDB00051 (HMDB)
pyruvateMetaboliteCHEBI:15361 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP250"
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