De novo biosynthesis of pyrimidine ribonucleotides (Saccharomyces cerevisiae)
From WikiPathways
Description
In yeast, the initial steps of de novo pyrimidine biosynthesis are catalyzed by the bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase Ura2p. In the first step, Ura2p catalyzes the synthesis of carbamoylphosphate from CO2, ATP, and glutamine. In the second, Ura2p condenses carbamoylphosphate with aspartate to yield ureidosuccinate/carbamoyl-L-aspartate. Third, dihydroorotase (Ura4p) catalyzes closure of the pyrimidine ring of ureidosuccinate to form dihydroorotate (DHO). DHO, in turn, is oxidized to orotic acid (OA), condensed with phosphoribosyl pyrophosphate to form orotidine 5-monophosphate, and finally decarboxylated to yield UMP. These three steps are catalyzed by Ura1p, Ura5p/Ura10p, and Ura3p, respectively. UMP may then undergo further processing to form other pyrimidines.
Source: https://pathway.yeastgenome.org/Quality Tags
Ontology Terms
Bibliography
- Wagner R, de Montigny J, de Wergifosse P, Souciet JL, Potier S; ''The ORF YBL042 of Saccharomyces cerevisiae encodes a uridine permease.''; FEMS Microbiol Lett, 1998 PubMed Europe PMC Scholia
- ''de novo biosynthesis of pyrimidine ribonucleotides''; YeastPathways,
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
2 ADP | Metabolite | 58-64-0 (CAS) | |
2 ATP | Metabolite | 1927-31-7 (CAS) | |
ADP | Metabolite | 58-64-0 (CAS) | |
ATP | Metabolite | 1927-31-7 (CAS) | |
CDP | Metabolite | 63-38-7 (CAS) | |
CO2 | Metabolite | 274 (Chemspider) | |
CTP | Metabolite | 6176 (PubChem-compound) | |
H+ | Metabolite | 1010 (Chemspider) | |
H2O | Metabolite | HMDB0002111 (HMDB) | |
HCO3- | Metabolite | 749 (Chemspider) | |
L-aspartate | Metabolite | CHEBI:29991 (ChEBI) | |
L-glutamate | Metabolite | 56-86-0 (CAS) | |
L-glutamine | Metabolite | 56-85-9 (CAS) | |
PRPP | Metabolite | 97-55-2 (CAS) | |
UDP | Metabolite | 1158 (PubChem-compound) | |
UMP | Metabolite | 6030 (PubChem-compound) | |
URA10 | GeneProduct | S000004884 (SGD) | |
URA1 | GeneProduct | S000001699 (SGD) | |
URA2 | GeneProduct | S000003666 (SGD) | |
URA3 | GeneProduct | S000000747 (SGD) | |
URA4 | GeneProduct | S000004412 (SGD) | |
URA5 | GeneProduct | S000004574 (SGD) | |
URA6 | GeneProduct | S000001507 (SGD) | |
URA7 | GeneProduct | S000000135 (SGD) | |
URA8 | GeneProduct | S000003864 (SGD) | |
UTP | Metabolite | 6133 (PubChem-compound) | |
YNK1 | GeneProduct | S000001550 (SGD) | |
carbamoyl-L-aspartate | Metabolite | 279 (PubChem-compound) | |
carbamoyl-phosphate | Metabolite | 3423467 (PubChem-compound) | |
dihydroorotate | Metabolite | 1232048 (Chemspider) | |
orotate | Metabolite | 942 (Chemspider) | |
orotidine-5'-phosphate | Metabolite | 160617 (PubChem-compound) | |
phosphate | Metabolite | 14265-44-2 (CAS) | |
pyrophosphate | Metabolite | 2466-09-3 (CAS) |
Annotated Interactions
No annotated interactions