Effect of dasatinib on the BCR-ABL signaling pathway (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none S122S248S459S215BCRY644ABL1GRB2SOS1VAV1Y428SHC1S428SHC2SHC3SHC4S147GAB2CBLCRKY426SRCINPP5DS330DOK1CRKLGRB2S147GAB2SHC2SHC3SHC4Y428SHC1MAPK pathwayMAPK3SPAGS164MAP3K2T365RPS6KA1S93T420EIF4BS15HSPB1HSPB2T71T69ATF2S258MEF2CT187T185MAPK1Y182MAPK11MAPK14ProliferationDifferentiationSurvivalS278BCL9JAK-STAT signalingS133S137PXNCRKLPTK2BCAR1PIK3CAPIK3R1ARAFBRAFRAF1KRASHRASNRASBCL2AKT1AKT2AKT3S290T257S285S268S287BCLAF1JAK-STAT signalingProliferationIncreased motilityDecreased adhesionBCL2Name: Effect of dasatinib on the BCR-ABL signaling pathwayOrganism: Homo sapiens


Description

Phosphorylation sites that are found to be suppressed by Dasatinib are shown. Based on fig 6 from https://pmc.ncbi.nlm.nih.gov/articles/PMC2816010/.

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Quality Tags

Image:Curated.pngReview changes for Approved

Ontology Terms

Bibliography

  1. Pan C, Olsen JV, Daub H, Mann M; ''Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.''; Mol Cell Proteomics, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135850
Approved
view01:42, 19 November 2024KhanspersModified description
135849view01:38, 19 November 2024KhanspersModified description
135848view01:35, 19 November 2024Khanspersmore phosphosites
135847view22:36, 18 November 2024Khanspersadded phosphosite comments
135746view16:43, 6 November 2024Khanspersupdated phospho sites
135745view16:35, 6 November 2024Khansperslayout
135741view00:38, 6 November 2024KhanspersOntology Term : 'altered growth factor signaling pathway' added !
135740view00:37, 6 November 2024KhanspersOntology Term : 'leukemia pathway' added !
135739view00:26, 6 November 2024Khanspersboard width
135738view00:26, 6 November 2024Khanspersboard width
135737view00:25, 6 November 2024Khanspersboard hieght
135736view00:24, 6 November 2024Khanspersboard height
135735view00:22, 6 November 2024Khansperslayout
135734view00:13, 6 November 2024KhanspersModified description
135733view00:11, 6 November 2024KhanspersModified description
135732view00:03, 6 November 2024KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
ABL1GeneProduct25 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene) OCR lexicon match: AKT
AKT2GeneProduct208 (Entrez Gene) OCR lexicon match: AKT
AKT3GeneProduct10000 (Entrez Gene) OCR lexicon match: AKT
ARAFGeneProduct369 (Entrez Gene) OCR lexicon match: RAF
ATF2GeneProduct1386 (Entrez Gene) OCR lexicon match: ATF2
BCAR1GeneProduct9564 (Entrez Gene) OCR lexicon match: CAS
BCL2GeneProduct596 (Entrez Gene) OCR lexicon match: BCL2
BCL9GeneProduct607 (Entrez Gene)
BCLAF1GeneProduct9774 (Entrez Gene) OCR lexicon match: BCLAF1
BCRGeneProduct613 (Entrez Gene)
BRAFGeneProduct673 (Entrez Gene) OCR lexicon match: RAF
CBLGeneProduct867 (Entrez Gene) OCR lexicon match: CBL
CRKGeneProduct1398 (Entrez Gene) OCR lexicon match: CRK
CRKLGeneProduct1399 (Entrez Gene)
DOK1GeneProduct1796 (Entrez Gene)
EIF4BGeneProduct1975 (Entrez Gene) OCR lexicon match: EIF4B
GAB2GeneProduct9846 (Entrez Gene) OCR lexicon match: GAB2
GRB2GeneProduct2885 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene) OCR lexicon match: RAS
HSPB1GeneProduct3315 (Entrez Gene) OCR lexicon match: HSP27
HSPB2GeneProduct3316 (Entrez Gene) OCR lexicon match: HSP27
INPP5DGeneProduct3635 (Entrez Gene)
JAK-STAT signalingPathway
KRASGeneProduct3845 (Entrez Gene) OCR lexicon match: RAS
MAP3K2GeneProduct10746 (Entrez Gene) OCR lexicon match: MEKK2
MAPK11GeneProduct5600 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MEF2CGeneProduct4208 (Entrez Gene) OCR lexicon match: MEF2C
NRASGeneProduct4893 (Entrez Gene) OCR lexicon match: RAS
PTK2GeneProduct5747 (Entrez Gene) OCR lexicon match: FAK
PXNGeneProduct5829 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene) OCR lexicon match: RAF
RPS6KA1GeneProduct6195 (Entrez Gene) OCR lexicon match: RSK
SHC1GeneProduct6464 (Entrez Gene) OCR lexicon match: SHC
SHC2GeneProduct25759 (Entrez Gene) OCR lexicon match: SHC
SHC3GeneProduct53358 (Entrez Gene) OCR lexicon match: SHC
SHC4GeneProduct399694 (Entrez Gene) OCR lexicon match: SHC
SOS1GeneProduct6654 (Entrez Gene)
SPAGGeneProduct
SRCGeneProduct6714 (Entrez Gene) OCR lexicon match: SRC
VAV1GeneProduct7409 (Entrez Gene)

Annotated Interactions

No annotated interactions

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