Hallmark of cancer: non-mutational epigenetic reprogramming (Homo sapiens)
From WikiPathways
Description
Hallmarks of Cancer: Nonmutational epigenetical programming
Quality Tags
Ontology Terms
Saving...Bibliography
View all... |
- Wang JY, Lu AQ; ''The biological function of m6A reader YTHDF2 and its role in human disease.''; Cancer Cell Int, 2021 PubMed Europe PMC Scholia
- Schöller E, Weichmann F, Treiber T, Ringle S, Treiber N, Flatley A, Feederle R, Bruckmann A, Meister G; ''Interactions, localization, and phosphorylation of the m(6)A generating METTL3-METTL14-WTAP complex.''; RNA, 2018 PubMed Europe PMC Scholia
- Durbin AD, Wang T, Wimalasena VK, Zimmerman MW, Li D, Dharia NV, Mariani L, Shendy NAM, Nance S, Patel AG, Shao Y, Mundada M, Maxham L, Park PMC, Sigua LH, Morita K, Conway AS, Robichaud AL, Perez-Atayde AR, Bikowitz MJ, Quinn TR, Wiest O, Easton J, Schönbrunn E, Bulyk ML, Abraham BJ, Stegmaier K, Look AT, Qi J; ''EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma.''; Cancer Discov, 2022 PubMed Europe PMC Scholia
- Tsiouplis NJ, Bailey DW, Chiou LF, Wissink FJ, Tsagaratou A; ''TET-Mediated Epigenetic Regulation in Immune Cell Development and Disease.''; Front Cell Dev Biol, 2020 PubMed Europe PMC Scholia
- Farooqi AA, Fayyaz S, Poltronieri P, Calin G, Mallardo M; ''Epigenetic deregulation in cancer: Enzyme players and non-coding RNAs.''; Semin Cancer Biol, 2022 PubMed Europe PMC Scholia
- Yan H, Zhang L, Cui X, Zheng S, Li R; ''Roles and mechanisms of the m(6)A reader YTHDC1 in biological processes and diseases.''; Cell Death Discov, 2022 PubMed Europe PMC Scholia
- Chen Z, Zhong X, Xia M, Zhong J; ''The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases.''; Mol Ther Nucleic Acids, 2021 PubMed Europe PMC Scholia
- Relier S, Ripoll J, Guillorit H, Amalric A, Achour C, Boissière F, Vialaret J, Attina A, Debart F, Choquet A, Macari F, Marchand V, Motorin Y, Samalin E, Vasseur JJ, Pannequin J, Aguilo F, Lopez-Crapez E, Hirtz C, Rivals E, Bastide A, David A; ''FTO-mediated cytoplasmic m(6)A(m) demethylation adjusts stem-like properties in colorectal cancer cell.''; Nat Commun, 2021 PubMed Europe PMC Scholia
- Shi H, Wang X, Lu Z, Zhao BS, Ma H, Hsu PJ, Liu C, He C; ''YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA.''; Cell Res, 2017 PubMed Europe PMC Scholia
- Zhang J, Yang C, Wu C, Cui W, Wang L; ''DNA Methyltransferases in Cancer: Biology, Paradox, Aberrations, and Targeted Therapy.''; Cancers (Basel), 2020 PubMed Europe PMC Scholia
History
View all... |
External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| ALKBH5 | Protein | ENSG00000150867 (Ensembl)  | |
| Adenosine | In RRACH domain | ||
| CREBP | Protein | ENSG00000005339 (Ensembl) | |
| CpGs in DNA | |||
| DNMT1 | Protein | ENSG00000130816 (Ensembl) | |
| DNMT3A | Protein | ENSG00000119772 (Ensembl) | |
| DNMT3B | Protein | ENSG00000142089 (Ensembl) | |
| EP300 | Protein | ENSG00000100393 (Ensembl) | |
| EZH2 | Protein | ENSG00000106462 (Ensembl) | |
| FTO | Protein | ENSG00000140718 (Ensembl) | |
| H2/3/4 | |||
| HDAC1 | Protein | ENSG00000116478 (Ensembl) | |
| HDAC2 | Protein | ENSG00000196591 (Ensembl) | |
| METTL14 | Protein | ENSG00000167741 (Ensembl) | |
| METTL3 | Protein | NSG00000083838 (Ensembl) | |
| TET1 | Protein | ENSG00000168769 (Ensembl) | |
| TET2 | Protein | ENSG00000168769 (Ensembl) | |
| TET3 | Protein | ENSG00000182985 (Ensembl) | |
| YTHDC1 | Protein | ENSG00000169047 (Ensembl) | |
| YTHDF1 | Protein | ENSG00000162408 (Ensembl) | |
| YTHDF2 | Protein | ENSG00000118454 (Ensembl) | YTHDF2 binds to m6A regions to promote degradation of mRNA |
| YTHDF3 | Protein | ENSG00000185728 (Ensembl) | YTHDF2 binds to m6A regions to promote degradation of mRNA |
| m6A | |||
| mRNA | |||
| pre-mRNA | RRACH Domain |
Annotated Interactions
No annotated interactions
