Targeting YAP in pancreatic ductal adenocarcinoma (PDAC) (Homo sapiens)

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Description

"Targeting YAP for PDAC therapy. There are several strategies for targeting YAP in PDAC. Statin-mediated inhibition of HMG-CoA reductase in the mevalonate pathway reduces the geranylgeranylation and membrane localization of Rho GTPases, restricting YAP nuclear accumulation and thus its activity. Verteporfin and VGLL4-mimicking peptides disrupt the interaction between YAP and TEAD, inhibiting YAP-induced transcription. Metformin activates AMPK, which inhibits YAP both directly and by activating LATS kinases. BET inhibitors oppose the transcription of YAP-regulated genes. Neratinib increases the phosphorylation of LATS1 and YAP, causing YAP cytosolic accumulation and degradation." Based on Figure F5 in https://pubmed.ncbi.nlm.nih.gov/33408779/. Derived from PFOCR, https://pfocr.wikipathways.org/figures/PMC7778590__thnov11p1753g005.html.

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Bibliography

  1. Mao W, Mai J, Peng H, Wan J, Sun T; ''YAP in pancreatic cancer: oncogenic role and therapeutic strategy.''; Theranostics, 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135790view18:03, 11 November 2024EweitzOntology Term : 'drug pathway' added !
135789view17:13, 11 November 2024EweitzOntology Term : 'pancreatic ductal cell' added !
135788view17:12, 11 November 2024EweitzOntology Term : 'pancreatic ductal adenocarcinoma' added !
135787view17:02, 11 November 2024EweitzConnect downstream cell phenotypes
135786view16:52, 11 November 2024EweitzAdd literature reference
135785view16:50, 11 November 2024EweitzLabel cell type, organelle
135784view16:38, 11 November 2024EweitzAdd CHEBI identifiers, refine labels
135783view16:26, 11 November 2024EweitzConnect nodes in mevalonate pathway
135782view16:21, 11 November 2024EweitzAdd interactions, groups, complexes
135781view15:54, 11 November 2024EweitzOrganize nodes
135780view15:33, 11 November 2024EweitzNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AtorvastatinMetabolite
CCN1GeneProductENSG00000142871 (Ensembl)
CCN2GeneProductENSG00000118523 (Ensembl)
FluvastatinMetabolite
HMG-CoAMetabolite
HMGCRGeneProductENSG00000113161 (Ensembl) "HMG-CoA reductase" originally
JQ1Metabolite
LATS1GeneProductENSG00000131023 (Ensembl)
LATS2GeneProductENSG00000150457 (Ensembl)
LovastatinMetabolite
MOB1AGeneProductENSG00000114978 (Ensembl)
MetforminMetabolite
Mevalonate pathwayPathway
Mevalonic acidMetabolite
NeratinibMetabolite
PRKAA1GeneProductENSG00000132356 (Ensembl)
PRKAA2GeneProductENSG00000162409 (Ensembl)
PRKAB1GeneProductENSG00000111725 (Ensembl)
PRKAB2GeneProductENSG00000131791 (Ensembl)
PRKAG1GeneProductENSG00000181929 (Ensembl)
PRKAG2GeneProductENSG00000106617 (Ensembl)
PRKAG3GeneProductENSG00000115592 (Ensembl)
PitavastatinMetabolite
PravastatinMetabolite
RHOAGeneProductENSG00000067560 (Ensembl)
RHOBGeneProductENSG00000143878 (Ensembl)
RHOCGeneProductENSG00000155366 (Ensembl)
RHODGeneProductENSG00000173156 (Ensembl)
RHOGeneProductENSG00000163914 (Ensembl)
RosuvastatinMetabolite
SAV1GeneProductENSG00000151748 (Ensembl)
STK3GeneProductENSG00000104375 (Ensembl)
STK4GeneProductENSG00000101109 (Ensembl)
SimvastatinMetabolite
TEAD1GeneProductENSG00000187079 (Ensembl)
TEAD2GeneProductENSG00000074219 (Ensembl)
TEAD3GeneProductENSG00000007866 (Ensembl)
TEAD4GeneProductENSG00000197905 (Ensembl)
VGLL4-mimicking peptidesMetabolite
VerteporfinMetabolite
YAP1GeneProductENSG00000137693 (Ensembl)

Annotated Interactions

No annotated interactions

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