Ubiquinol-6 biosynthesis from 4-hydroxybenzoate (Saccharomyces cerevisiae)

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Description

The main ubiquinone in Saccharomyces cerevisiae and other Saccharomycetes species is ubiquinone-6. Biosynthesis of 4-hydroxybenzoate, one of the precursors, can occur in yeast by two different paths - it may be produced directly from chorismate by the chorismate pyruvate-lyase reaction (similar to the common pathway in prokaryotes), or it can be synthesized from L-tyrosine, similar to higher eukaryotes (see 4-hydroxybenzoate biosynthesis I (eukaryotes)). At least 10 genes (COQ1-COQ10) have been shown to be required for synthesis of ubiquinone in Saccharomyces cerevisiae.

At least six of these proteins (COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9) were shown to form a complex, which may be attached to the mitochindria inner membrane by the product of COQ2, an integral membrane protein.

Description adapted from https://pathway.yeastgenome.org/.

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Ontology Terms

 

Bibliography

  1. ''ubiquinol-6 biosynthesis from 4-hydroxybenzoate (eukaryotic)''; YeastPathways,

History

View all...
CompareRevisionActionTimeUserComment
136043view04:51, 10 December 2024KhanspersOntology Term : 'metabolic pathway of cofactors, vitamins, nutrients' added !
136042view04:50, 10 December 2024KhanspersModified description
136041view04:47, 10 December 2024KhanspersOntology Term : 'classic metabolic pathway' added !
136040view04:47, 10 December 2024Khanspersremoved GenMAPP comments and updated reference
136039view04:46, 10 December 2024Khanspersreference and updated content
136029view01:13, 10 December 2024Khanspersupdate in progress
135510view20:41, 20 September 2024KhanspersModified title
135509view20:41, 20 September 2024KhanspersModified title
117360view11:56, 20 May 2021EweitzModified title
69848view16:01, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69576view20:28, 8 July 2013MaintBotUpdated to 2013 gpml schema
67738view11:56, 26 June 2013DdiglesOntology Term : 'ubiquinone biosynthetic pathway' added !
41798view04:48, 2 March 2011MaintBotRemoved redundant pathway information and comments
21283view11:31, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Ubiquinone Q Prenylation]] moved to [[Pathway:WP287]]: Moved to stable identifier
12891view08:07, 17 May 2008MaintBotautomated metabolite conversion
9002view14:14, 7 January 2008MaintBotAdded to category $category
9000view14:14, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-hexaprenyl-6-methoxyphenolMetabolite1109 (ChEBI)
2-methoxy-6-all trans-hexaprenyl-1,4-benzoquinol Metabolite61472 (ChEBI)
3,4-dihydroxy-5-all-trans-hexaprenylbenzoate Metabolite58373 (ChEBI)
3-demethylubiquinol-6Metabolite64253 (ChEBI)
3-hexaprenyl-4-hydroxybenzoate Metabolite84492 (ChEBI)
3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoateMetabolite57916 (ChEBI)
4-hydroxybenzoateMetabolite30763 (ChEBI)
6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinolMetabolite61473 (ChEBI)
CAT5GeneProductS000005651 (SGD)
CO2Metabolite16526 (ChEBI)
COQ2GeneProductS000005324 (SGD)
COQ3GeneProductS000005456 (SGD)
COQ5GeneProductS000004578 (SGD)
COQ6GeneProductS000003487 (SGD)
H+Metabolite15378 (ChEBI)
H2OMetabolite15377 (ChEBI)
NADP+Metabolite58349 (ChEBI)
NADPHMetabolite57783 (ChEBI)
O2Metabolite15379 (ChEBI)
S-adenosyl-L-homocysteineMetabolite57856 (ChEBI)
S-adenosyl-L-methionineMetabolite59789 (ChEBI)
a reduced electron acceptorMetabolite17499 (ChEBI)
all-trans-hexaprenyl diphosphateMetabolite58179 (ChEBI)
an oxidized electron acceptorMetabolite15339 (ChEBI)
pyrophosphateMetabolite2466-09-3 (CAS)
ubiquinol-6Metabolite52970 (ChEBI)

Annotated Interactions

No annotated interactions

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