Vedolizumab therapy for inflammatory bowel disease (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none LymphocyteCaptureVedolizumabITGA4ITGB7ITGA4ITGB1ITGA2ITGB2SELPLGSELEITGA4ITGB7ITGA4ITGB1ITGA2ITGB2SELPLGSELEVedolizumabITGA4ITGB7ITGA4ITGB1ITGA2ITGB2SELPLGICAM1VCAM1MADCAM1RollingAdhesion andactivationMigration tointestinal mucosaVascular endothelial cellName: Vedolizumab therapy for irritable bowel syndromeOrganism: Homo sapiens


Description

"Process of lymphocyte migration from the blood vessels to the intestinal mucosa and mechanism of action of vedolizumab." Inspired by Figure 1 in https://pubmed.ncbi.nlm.nih.gov/31470005/.

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Quality Tags

Image:Curated.pngReview changes for Approved

Ontology Terms

Bibliography

  1. Eugeni Domenecha, Javier P. Gisbert; ''Efficacy and safety of vedolizumab in the treatment of ulcerative colitis''; Gastroenterologia y Hepatologia, 2016

History

View all...
CompareRevisionActionTimeUserComment
137069
Approved
view03:02, 27 February 2025EweitzOntology Term : 'inflammatory bowel disease' added !
137068view03:01, 27 February 2025EweitzOntology Term : 'DOID:9778' removed !
137067view03:01, 27 February 2025EweitzModified title
136453view01:04, 3 February 2025EweitzShrink last nucleus
136452view01:03, 3 February 2025EweitzEconomize layout
136450view22:16, 2 February 2025EweitzRefine graphical X placement
136449view22:01, 2 February 2025EweitzRemove a rolling indicator due to curved line rendering bug
136448view22:00, 2 February 2025EweitzMitigate graphical bug due to PathVisio / Kaavio discrepancy
136447view21:59, 2 February 2025EweitzMitigate graphical bug due to PathVisio / Kaavio discrepancy
136446view21:58, 2 February 2025EweitzAdd, refine rolling indicator
136445view21:50, 2 February 2025EweitzOntology Term : 'ulcerative colitis' added !
136444view21:49, 2 February 2025EweitzOntology Term : 'Crohn's disease' added !
136443view21:47, 2 February 2025EweitzOntology Term : 'irritable bowel syndrome' added !
136442view21:47, 2 February 2025EweitzOntology Term : 'lymphocyte' added !
136441view21:46, 2 February 2025EweitzOntology Term : 'endothelial cell of vascular tree' added !
136440view21:46, 2 February 2025EweitzModified description
136439view21:43, 2 February 2025EweitzAdd literature reference
136438view21:41, 2 February 2025EweitzAbut endothelial cells
136437view21:39, 2 February 2025EweitzAdd familiar terms
136436view21:35, 2 February 2025EweitzModified description
136435view21:32, 2 February 2025EweitzLabel tissues
136434view21:28, 2 February 2025EweitzAdjust position of cell type label, nucleus
136433view21:25, 2 February 2025EweitzFix connection
136432view21:24, 2 February 2025EweitzRefine color, add interaction
136431view21:22, 2 February 2025EweitzRefine color
136430view21:20, 2 February 2025EweitzAdd color
136429view21:06, 2 February 2025EweitzAdd process phases, label cell types
136428view13:28, 2 February 2025EweitzRefine graphics
136427view13:27, 2 February 2025EweitzUpgrade to complexes, add interactions
136426view13:13, 2 February 2025EweitzNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ICAM1GeneProductENSG00000090339 (Ensembl)
ITGA2GeneProductENSG00000164171 (Ensembl)
ITGA4GeneProductENSG00000115232 (Ensembl)
ITGB1GeneProductENSG00000150093 (Ensembl)
ITGB2GeneProductENSG00000160255 (Ensembl)
ITGB7GeneProductENSG00000139626 (Ensembl)
MADCAM1GeneProductENSG00000099866 (Ensembl)
SELEGeneProductENSG00000007908 (Ensembl)
SELPLGGeneProductENSG00000110876 (Ensembl)
VCAM1GeneProductENSG00000162692 (Ensembl)
VedolizumabMetaboliteDB09033 (DrugBank)

Annotated Interactions

No annotated interactions

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