Vedolizumab therapy for inflammatory bowel disease (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none LymphocyteCaptureVedolizumabITGA4ITGB7ITGA4ITGB1ITGA2ITGB2SELPLGSELEITGA4ITGB7ITGA4ITGB1ITGA2ITGB2SELPLGSELEVedolizumabITGA4ITGB7ITGA4ITGB1ITGA2ITGB2SELPLGICAM1VCAM1MADCAM1RollingAdhesion andactivationMigration tointestinal mucosaVascular endothelial cellVascular endotheliumIntestinalmucosaBlood streamIntestinal tissueName: Vedolizumab therapy for irritable bowel syndromeOrganism: Homo sapiens


Description

"Vedolizumab is a humanized monoclonal antibody with a predominantly gastrointestinal effect. It specifically inhibits leucocyte integrin α4β7, thus preventing its interaction with mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1), which is involved in the migration of lymphocytes from the blood stream to the intestinal tissue. Vedolizumab is indicated in the treatment of moderate to severe active Crohn's disease and ulcerative colitis in adult patients with poor response, loss of response, or intolerance to conventional treatment or to tumour necrosis factor alpha (TNF-α) antagonists." Inspired by Figure 1 in https://pubmed.ncbi.nlm.nih.gov/31470005/. Vedolizumab is also known by its trade name, Entyvio.

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Quality Tags

Image:Curated.pngReview changes for Approved

Ontology Terms

Bibliography

  1. Eugeni Domenecha, Javier P. Gisbert; ''Efficacy and safety of vedolizumab in the treatment of ulcerative colitis''; Gastroenterologia y Hepatologia, 2016

History

View all...
CompareRevisionActionTimeUserComment
137069
Approved
view03:02, 27 February 2025EweitzOntology Term : 'inflammatory bowel disease' added !
137068view03:01, 27 February 2025EweitzOntology Term : 'DOID:9778' removed !
137067view03:01, 27 February 2025EweitzModified title
136453view01:04, 3 February 2025EweitzShrink last nucleus
136452view01:03, 3 February 2025EweitzEconomize layout
136450view22:16, 2 February 2025EweitzRefine graphical X placement
136449view22:01, 2 February 2025EweitzRemove a rolling indicator due to curved line rendering bug
136448view22:00, 2 February 2025EweitzMitigate graphical bug due to PathVisio / Kaavio discrepancy
136447view21:59, 2 February 2025EweitzMitigate graphical bug due to PathVisio / Kaavio discrepancy
136446view21:58, 2 February 2025EweitzAdd, refine rolling indicator
136445view21:50, 2 February 2025EweitzOntology Term : 'ulcerative colitis' added !
136444view21:49, 2 February 2025EweitzOntology Term : 'Crohn's disease' added !
136443view21:47, 2 February 2025EweitzOntology Term : 'irritable bowel syndrome' added !
136442view21:47, 2 February 2025EweitzOntology Term : 'lymphocyte' added !
136441view21:46, 2 February 2025EweitzOntology Term : 'endothelial cell of vascular tree' added !
136440view21:46, 2 February 2025EweitzModified description
136439view21:43, 2 February 2025EweitzAdd literature reference
136438view21:41, 2 February 2025EweitzAbut endothelial cells
136437view21:39, 2 February 2025EweitzAdd familiar terms
136436view21:35, 2 February 2025EweitzModified description
136435view21:32, 2 February 2025EweitzLabel tissues
136434view21:28, 2 February 2025EweitzAdjust position of cell type label, nucleus
136433view21:25, 2 February 2025EweitzFix connection
136432view21:24, 2 February 2025EweitzRefine color, add interaction
136431view21:22, 2 February 2025EweitzRefine color
136430view21:20, 2 February 2025EweitzAdd color
136429view21:06, 2 February 2025EweitzAdd process phases, label cell types
136428view13:28, 2 February 2025EweitzRefine graphics
136427view13:27, 2 February 2025EweitzUpgrade to complexes, add interactions
136426view13:13, 2 February 2025EweitzNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ICAM1GeneProductENSG00000090339 (Ensembl)
ITGA2GeneProductENSG00000164171 (Ensembl)
ITGA4GeneProductENSG00000115232 (Ensembl)
ITGB1GeneProductENSG00000150093 (Ensembl)
ITGB2GeneProductENSG00000160255 (Ensembl)
ITGB7GeneProductENSG00000139626 (Ensembl)
MADCAM1GeneProductENSG00000099866 (Ensembl)
SELEGeneProductENSG00000007908 (Ensembl)
SELPLGGeneProductENSG00000110876 (Ensembl)
VCAM1GeneProductENSG00000162692 (Ensembl)
VedolizumabMetaboliteDB09033 (DrugBank)

Annotated Interactions

No annotated interactions

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