NSAIDs mechanism of action (Homo sapiens)

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Description

"Nonsteroidal anti-inflammatory drugs (NSAIDs)

inhibit the cyclooxygenase isoenzymes COX1 and COX2 with varying degrees of specificity for the COX2 isoform. As a result, the conversion of arachidonic acid to

prostaglandins (PGs) is inhibited. The main effects of PGs throughout the body are listed." Inspired by Figure 1 in PMID:32322101.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Schjerning AM, McGettigan P, Gislason G; ''Cardiovascular effects and safety of (non-aspirin) NSAIDs.''; Nat Rev Cardiol, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
139179view13:02, 24 May 2025EweitzModified description
139178view12:58, 24 May 2025EweitzRefine gene identifiers
136464view13:09, 3 February 2025EweitzModified description
136463view13:08, 3 February 2025EweitzOntology Term : 'drug pathway' added !
136462view13:07, 3 February 2025EweitzWiden nodes
136461view13:07, 3 February 2025EweitzWiden node
136460view13:06, 3 February 2025EweitzWiden node
136459view13:06, 3 February 2025EweitzRemove anchor
136458view13:05, 3 February 2025EweitzConnect downstream effects
136457view13:01, 3 February 2025EweitzAdd literature reference
136456view13:00, 3 February 2025EweitzAdd more nodes, interactions, labels
136454view03:08, 3 February 2025EweitzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Arachidonic acidMetabolite
COX1GeneProduct
COX2GeneProduct
Metabolite
PGD2MetaboliteCHEBI:15555 (ChEBI)
PGE2MetaboliteCHEBI:15551 (ChEBI)
PGF2aMetaboliteCHEBI:15553 (ChEBI)
PGI2MetaboliteCHEBI:15552 (ChEBI)

Annotated Interactions

No annotated interactions

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