NSAIDs mechanism of action (Homo sapiens)

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Description

"Nonsteroidal anti-inflammatory drugs (NSAIDs)

inhibit the cyclooxygenase isoenzymes COX1 and COX2 with varying degrees of specificity for the COX2 isoform. As a result, the conversion of arachidonic acid to

prostaglandins (PGs) is inhibited. The main effects of PGs throughout the body are listed." Inspired by Figure 1 in PMID:32322101.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Schjerning AM, McGettigan P, Gislason G; ''Cardiovascular effects and safety of (non-aspirin) NSAIDs.''; Nat Rev Cardiol, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
139179view13:02, 24 May 2025EweitzModified description
139178view12:58, 24 May 2025EweitzRefine gene identifiers
136464view13:09, 3 February 2025EweitzModified description
136463view13:08, 3 February 2025EweitzOntology Term : 'drug pathway' added !
136462view13:07, 3 February 2025EweitzWiden nodes
136461view13:07, 3 February 2025EweitzWiden node
136460view13:06, 3 February 2025EweitzWiden node
136459view13:06, 3 February 2025EweitzRemove anchor
136458view13:05, 3 February 2025EweitzConnect downstream effects
136457view13:01, 3 February 2025EweitzAdd literature reference
136456view13:00, 3 February 2025EweitzAdd more nodes, interactions, labels
136454view03:08, 3 February 2025EweitzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AngiogenesisPathwayWP1539 (WikiPathways)
Arachidonic acidMetabolite
COX1GeneProduct
COX2GeneProduct
CelecoxibMetaboliteDB00482 (DrugBank)
Cell proliferationQ189101 (Wikidata)
DiclofenacMetaboliteDB00586 (DrugBank)
HemostasisQ487937 (Wikidata)
IbuprofenMetaboliteDB01050 (DrugBank)
InflammationQ101991 (Wikidata)
MetastasisQ181876 (Wikidata)
NaproxenMetaboliteDB00788 (DrugBank)
PGA1MetaboliteCHEBI:15545 (ChEBI)
PGD2MetaboliteCHEBI:15555 (ChEBI)
PGE1MetaboliteCHEBI:15544 (ChEBI)
PGE2MetaboliteCHEBI:15551 (ChEBI)
PGF2aMetaboliteCHEBI:15553 (ChEBI)
PGG2MetaboliteCHEBI:27647 (ChEBI)
PGH2MetaboliteCHEBI:15554 (ChEBI)
PGI2MetaboliteCHEBI:15552 (ChEBI)
PainQ81938 (Wikidata)
Protection of gastric mucosaQ383249 (Wikidata)
RofecoxibMetaboliteDB00533 (DrugBank)
Tissue injuryQ21119857 (Wikidata)

Annotated Interactions

No annotated interactions

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