Altered glycosylation of MUC1 in tumor microenvironment (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none NucleusCytokine transcriptionT cellRecruitment ofinflammatory cellsIKBKGCHUKIKBKBTNFIL6NFKBIARELANFKB1MUC1NFKB1RELAMUC1RELANFKB1Dendritic cellMacrophagePNFKBIADNATumor cellName: Altered glycosylation of MUC1 in tumor microenvironmentOrganism: Homo sapiens


Description

Altered MUC1 glycosylation extends to its role as a promoter of chronic inflammatory conditions that lead to malignant transformation and cancer progression. Derived from Figure 3 in https://pmc.ncbi.nlm.nih.gov/articles/PMC5197949/.

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Quality Tags

Image:Curated.pngReview changes for Approved
Image:Wplogo_31.pngCommunity: PancCanNet
Image:Wplogo_31.pngCommunity: CPTAC

Ontology Terms

Pathway Ontology : disease pathway
Disease : COVID-19
 

Bibliography

  1. Cascio S, Finn OJ; ''Intra- and Extra-Cellular Events Related to Altered Glycosylation of MUC1 Promote Chronic Inflammation, Tumor Progression, Invasion, and Metastasis.''; Biomolecules, 2016 PubMed Europe PMC Scholia
  2. Gilmore TD; ''Introduction to NF-kappaB: players, pathways, perspectives.''; Oncogene, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137147
Approved
view23:20, 27 February 2025KhanspersModified description
136650view13:16, 18 February 2025EweitzModified description
136649view13:16, 18 February 2025EweitzOntology Term : 'neoplastic cell' added !
136648view13:14, 18 February 2025EweitzAdd more content per source
136647view13:05, 18 February 2025EweitzAdd cell type label: tumor cell
136646view13:03, 18 February 2025EweitzEconomize layout
136645view12:49, 18 February 2025EweitzModified description
136644view12:46, 18 February 2025EweitzStandardize case
136643view12:44, 18 February 2025EweitzUpgrade state node, align nodes
136642view12:38, 18 February 2025EweitzUse standard cell type name
136641view12:36, 18 February 2025EweitzEconomize layout
129205
PancCanNet
CPTAC
view01:24, 16 March 2024EweitzOntology Term : 'cancer pathway' added !
129204view01:24, 16 March 2024EweitzOntology Term : 'cancer' added !
129203view01:24, 16 March 2024EweitzOntology Term : 'dendritic cell' added !
129202view01:23, 16 March 2024EweitzOntology Term : 'macrophage' added !
129201view01:23, 16 March 2024EweitzOntology Term : 'T cell' added !
129199view16:42, 15 March 2024EgonwOntology Term : 'disease pathway' added !
121701view03:48, 26 February 2022EweitzFix gene symbol
117819view14:55, 22 May 2021EweitzModified title
107458view17:41, 10 October 2019KhanspersModified title
102530view01:31, 4 January 2019Khanspersconnected interactions
102254view10:46, 13 December 2018LaurentVisual aspects
102245view14:04, 12 December 2018LaurentVisual aspects
102239view13:11, 12 December 2018LaurentChanged typos
102238view13:08, 12 December 2018LaurentNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
CHUKGeneProduct1147 (Entrez Gene)
IKBKBGeneProduct3551 (Entrez Gene)
IKBKGGeneProduct8517 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
MUC1GeneProduct4582 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
NFKBIAGeneProduct4792 (Entrez Gene) "IkBA" originally
RELAGeneProduct5970 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)

Annotated Interactions

No annotated interactions

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