Altered glycosylation of MUC1 in tumor microenvironment (Homo sapiens)
From WikiPathways
Description
Altered MUC1 glycosylation extends to its role as a promoter of chronic inflammatory conditions that lead to malignant transformation
and cancer progression. Derived from Figure 3 in https://pmc.ncbi.nlm.nih.gov/articles/PMC5197949/.
Quality Tags
Ontology Terms
Pathway Ontology : disease pathway cancer pathway
Disease : cancer
Bibliography
- Cascio S, Finn OJ; ''Intra- and Extra-Cellular Events Related to Altered Glycosylation of MUC1 Promote Chronic Inflammation, Tumor Progression, Invasion, and Metastasis.''; Biomolecules, 2016 PubMed Europe PMC Scholia
- Gilmore TD; ''Introduction to NF-kappaB: players, pathways, perspectives.''; Oncogene, 2006 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name ![]() | Type ![]() | Database reference ![]() | Comment ![]() |
---|---|---|---|
CHUK | GeneProduct | 1147 (Entrez Gene) ![]() | |
IKBKB | GeneProduct | 3551 (Entrez Gene) ![]() | |
IKBKG | GeneProduct | 8517 (Entrez Gene) ![]() | |
IL6 | GeneProduct | 3569 (Entrez Gene) ![]() | |
MUC1 | GeneProduct | 4582 (Entrez Gene) ![]() | |
NFKB1 | GeneProduct | 4790 (Entrez Gene) ![]() | |
NFKBIA | GeneProduct | 4792 (Entrez Gene) ![]() | "IkBA" originally |
RELA | GeneProduct | 5970 (Entrez Gene) ![]() | |
TNF | GeneProduct | 7124 (Entrez Gene) ![]() |
Annotated Interactions
No annotated interactions