miRNA regulation of p53 pathway in prostate cancer (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none gamma-radiationGenotoxic drugsStress signalsp53 negative feedbackUVNutritiondeprivationHeat/Cold shockDNA damageATMCell cyclePCHEK2PTP53DNAROSNitric oxideMIR4482MIR548CMIR1305MIR548BMDM2SIAH1PTENP48SESN3SERPINE1ScotinPERPZMAT3SIAH1EI24BAXTNFRSF10BMIR548CPMAIP1BBC3MIR1305CASP8MIR27BMIR4491MIR548CMIR1305BIDMIR548BMIR27BMIR320AMIR182MIR4482MIR548CMIR19aMIR1305Inhibition of IGF-1/mTOR pathwayDNA repair anddamage preventionInhibition of angiogenesisand metastasisMIR27BMIR320AMIR548CMIR1305TP53AIP1CYS1APAF1MIR548CCASP9CASP3ApoptosisHypoxiaApoptosisName: miRNA regulation of p53 pathway in prostate cancerOrganism: Homo sapiens


Description

Diagrammatic scheme depicting targeted p53 pathway-related genes by upregulated miRNAs in prostate tumor cells. An integrated in silico and computational prediction databases (DIANA-micro T-CDS, miRBase, and TargetScan) were employed section to predict potential targets of a subset of highly upregulated miRNAs (>2-fold) in prostate tumors.

Note that some targeting miRNAs were removed from the original publication figure for clarity. These are represented in supplementary table S3: http://journals.sagepub.com/doi/suppl/10.1177/1535370216681554.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Image:Curated.pngReview changes for Approved
Image:Wplogo_31.pngCommunity: CPTAC

Ontology Terms

 

Bibliography

  1. Moustafa AA, Ziada M, Elshaikh A, Datta A, Kim H, Moroz K, Srivastav S, Thomas R, Silberstein JL, Moparty K, Salem FE, El-Habit OH, Abdel-Mageed AB; ''Identification of microRNA signature and potential pathway targets in prostate cancer.''; Exp Biol Med (Maywood), 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137141
Approved
view23:16, 27 February 2025KhanspersModified description
136733view03:07, 20 February 2025EweitzFix truncated text in gene node
136732view03:06, 20 February 2025EweitzUpgrade to pathway nodes
136731view03:02, 20 February 2025EweitzEconomize layout
128740view04:50, 21 February 2024EweitzUpgrade disease node
108115
CPTAC
view10:22, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106438view23:26, 28 August 2019KhanspersModified description
105493view05:48, 8 August 2019KhanspersModified description
96401view10:16, 12 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
94298view21:19, 31 August 2017KhanspersModified description
94296view21:18, 31 August 2017KhanspersModified description
94294view21:11, 31 August 2017Khanspers
92330view23:26, 23 May 2017Khanspersconnected interaction
92309view19:00, 19 May 2017KhanspersOntology Term : 'prostate cancer' added !
92308view19:00, 19 May 2017KhanspersModified description
92301view18:56, 19 May 2017KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
APAF1GeneProductENSG00000120868 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
BAXGeneProductENSG00000087088 (Ensembl)
BBC3GeneProductENSG00000105327 (Ensembl)
BIDGeneProductENSG00000015475 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CHEK2GeneProductENSG00000183765 (Ensembl)
CYS1GeneProductENSG00000205795 (Ensembl)
Cell cyclePathwayWP179 (WikiPathways)
DNAMetaboliteCHEBI:16991 (ChEBI)
EI24GeneProductENSG00000149547 (Ensembl)
HypoxiaQ105688 (Wikidata)
MDM2GeneProductENSG00000135679 (Ensembl)
MIR1305GeneProductENSG00000221227 (Ensembl)
MIR182GeneProductENSG00000207990 (Ensembl)
MIR19aGeneProductMIMAT0004490 (miRBase mature sequence) Annotated with MIMAT because BridegDb not yet up-to-date with latest from Entrez for this entity
MIR27BGeneProductENSG00000207864 (Ensembl)
MIR320AGeneProductENSG00000208037 (Ensembl)
MIR4482GeneProductENSG00000266852 (Ensembl)
MIR4491GeneProductENSG00000264032 (Ensembl)
MIR548BGeneProductENSG00000207982 (Ensembl)
MIR548CGeneProductENSG00000207546 (Ensembl)
Nitric oxideMetaboliteCHEBI:16480 (ChEBI)
P48GeneProductENSG00000134574 (Ensembl)
PERPGeneProductENSG00000112378 (Ensembl)
PMAIP1GeneProductENSG00000141682 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
ROSMetaboliteQ424361 (Wikidata)
SERPINE1GeneProductENSG00000106366 (Ensembl)
SESN3GeneProductENSG00000149212 (Ensembl)
SIAH1GeneProductENSG00000196470 (Ensembl)
ScotinGeneProductENSG00000164054 (Ensembl)
TNFRSF10BGeneProductENSG00000120889 (Ensembl)
TP53AIP1GeneProductENSG00000120471 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
ZMAT3GeneProductENSG00000172667 (Ensembl)

Annotated Interactions

No annotated interactions

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