G protein signaling (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none CellresponseGiCellresponseAKAPsPhosphatase 2BG gammaGqProtein kinase CG12/13TranscriptionAdenylate cyclasesG betaTranscriptioncAMPphosphodiesterasesProtein kinase AGsCytoskeletalchangesIP3Ca2+DAGCALM1KCNJ3PLCB3RHOAARHGEF1cAMPITPR1SLC9A1GNA13GNA12GNAQGNA14GNA11GNA15GNASGNALRRASNRASHRASKRASPDE7BPDE4APDE1BPDE4DPDE8BPDE1APDE1CPDE8APDE4CPDE4BPDE7APRKAR2BPRKAR1BPRKAR1APRKACBPRKAR2APRKACAPRKACGPPP3CCPPP3CAPPP3CCADCY3ADCY5ADCY4ADCY6ADCY2ADCY9ADCY1ADCY8ADCY7GNB3GNB2GNB5GNB1GNG10GNG12GNG11GNG13GNGT1GNGT2GNG8GNG7GNG5GNG3GNG4PRKCDPRKCB1PRKCHPRKD1PRKD3PRKCQPRKCEPRKCGPRKCAPRKCIPRKCZGNAO1GNAZGNAI1GNAO1GNAI3GNAI1GNAI2AKAP8AKAP1AKAP5AKAP7AKAP3AKAP6AKAP13AKAP12AKAP4AKAP11AKAP2AKAP10AKAP9Name: G protein signalingLast Modified: 10/16/2013Organism: Homo sapiens


Description

G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades.

G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes.

Source: [Wikipedia](https://en.wikipedia.org/wiki/G_protein)

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP35)

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

 

Bibliography

  1. Neves SR, Ram PT, Iyengar R; ''G protein pathways.''; Science, 2002 PubMed Europe PMC Scholia
  2. Stryer L, Bourne HR; ''G proteins: a family of signal transducers.''; Annu Rev Cell Biol, 1986 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
136961
Approved
view19:54, 26 February 2025KhanspersModified description
129753view01:59, 22 May 2024EweitzModified title
128000view03:25, 21 January 2024EweitzRefine label position, standardize case
117729view12:36, 22 May 2021EweitzModified title
106737view13:22, 17 September 2019MaintBotHMDB identifier normalization
106428view23:20, 28 August 2019KhanspersModified description
105604view04:51, 10 August 2019KhanspersModified description
88601view20:02, 11 August 2016Mkutmonfix unconnected lines
79952view11:32, 28 April 2015Zarichanded Id for IP3 metabolite
71252view20:48, 16 October 2013MaintBotAutomated update of data sources
63188view20:49, 8 May 2013MaintBotUpdating gpml version
45294view19:16, 7 October 2011AlexanderPicoOntology Term : 'PW:0000227' removed !
45292view19:15, 7 October 2011AlexanderPicoOntology Term : 'G protein mediated signaling pathway via Galphas family' added !
45291view19:15, 7 October 2011AlexanderPicoOntology Term : 'G protein mediated signaling pathway via Galphas family' added !
45290view19:15, 7 October 2011AlexanderPicoOntology Term : 'G protein mediated signaling pathway via Galphaq family' added !
45289view19:14, 7 October 2011AlexanderPicoOntology Term : 'G protein mediated signaling pathway via Galphai family' added !
45287view19:14, 7 October 2011AlexanderPicoOntology Term : 'G protein mediated signaling pathway via Galpha12/Galpha13 family' added !
45286view19:13, 7 October 2011AlexanderPicoOntology Term : 'G protein mediated signaling pathway' added !
43862view21:35, 9 August 2011Samuel SklarPeriodical save, work in progress
41095view23:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
35311view08:13, 12 February 2010ThomasModified description
35310view08:12, 12 February 2010Thomasadded literature
32404view17:03, 15 August 2009MaintBotFixed text labels
32059view13:33, 14 August 2009MaintBotFixed group labels
20751view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:G Protein Signaling]] moved to [[Pathway:WP35]]: Moved to stable identifier
14621view07:30, 23 May 2008AlexanderPicoGrouped, connected, fixed labels and metabolites
14619view07:25, 23 May 2008AlexanderPicoPeriodical save, work in progress
14614view07:15, 23 May 2008AlexanderPicoPeriodical save, work in progress
14610view07:05, 23 May 2008AlexanderPicoPeriodical save, work in progress
12924view10:40, 17 May 2008MaintBotSticky edges patch by Sjoerd
8072view13:46, 7 January 2008MaintBot[[Pathway:Human:G Protein Signaling]] moved to [[Pathway:Homo sapiens:G Protein Signaling]]: Renaming species
7658view16:07, 18 December 2007MaintBotfixed category names
7225view12:41, 4 November 2007MaintBotAdded categories to GPML
19467view22:17, 22 May 2007C.Redferngpml file for [[Human:G_Protein_Signaling]]
19466view22:17, 22 May 2007BruceConklingpml file for [[Human:G_Protein_Signaling]]
6325view22:17, 22 May 2007Nsalomonisgpml file for [[Human:G_Protein_Signaling]]

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ADCY1GeneProduct107 (Entrez Gene)
ADCY2GeneProduct108 (Entrez Gene)
ADCY3GeneProduct109 (Entrez Gene)
ADCY4GeneProduct196883 (Entrez Gene)
ADCY5GeneProduct111 (Entrez Gene)
ADCY6GeneProduct112 (Entrez Gene)
ADCY7GeneProduct113 (Entrez Gene)
ADCY8GeneProduct114 (Entrez Gene)
ADCY9GeneProduct115 (Entrez Gene)
AKAP10GeneProduct11216 (Entrez Gene)
AKAP11GeneProduct11215 (Entrez Gene)
AKAP12GeneProduct9590 (Entrez Gene)
AKAP13GeneProduct11214 (Entrez Gene)
AKAP1GeneProduct8165 (Entrez Gene)
AKAP2GeneProduct11217 (Entrez Gene)
AKAP3GeneProduct10566 (Entrez Gene)
AKAP4GeneProduct8852 (Entrez Gene)
AKAP5GeneProduct9495 (Entrez Gene)
AKAP6GeneProduct9472 (Entrez Gene)
AKAP7GeneProduct9465 (Entrez Gene)
AKAP8GeneProduct10270 (Entrez Gene)
AKAP9GeneProduct10142 (Entrez Gene)
ARHGEF1GeneProduct9138 (Entrez Gene)
CALM1GeneProduct801 (Entrez Gene)
Ca2+MetaboliteHMDB0000464 (HMDB)
DAGMetaboliteC00165 (KEGG Compound)
GNA11GeneProduct2767 (Entrez Gene)
GNA12GeneProduct2768 (Entrez Gene)
GNA13GeneProduct10672 (Entrez Gene)
GNA14GeneProduct9630 (Entrez Gene)
GNA15GeneProduct2769 (Entrez Gene)
GNAI1GeneProduct2770 (Entrez Gene)
GNAI2GeneProduct2771 (Entrez Gene)
GNAI3GeneProduct2773 (Entrez Gene)
GNALGeneProduct2774 (Entrez Gene)
GNAO1GeneProduct2775 (Entrez Gene)
GNAQGeneProduct2776 (Entrez Gene)
GNASGeneProduct2778 (Entrez Gene)
GNAZGeneProduct2781 (Entrez Gene)
GNB1GeneProduct2782 (Entrez Gene)
GNB2GeneProduct2783 (Entrez Gene)
GNB3GeneProduct2784 (Entrez Gene)
GNB5GeneProduct10681 (Entrez Gene)
GNG10GeneProduct2790 (Entrez Gene)
GNG11GeneProduct2791 (Entrez Gene)
GNG12GeneProduct55970 (Entrez Gene)
GNG13GeneProduct51764 (Entrez Gene)
GNG3GeneProduct2785 (Entrez Gene)
GNG4GeneProduct2786 (Entrez Gene)
GNG5GeneProduct2787 (Entrez Gene)
GNG7GeneProduct2788 (Entrez Gene)
GNG8GeneProduct94235 (Entrez Gene)
GNGT1GeneProduct2792 (Entrez Gene)
GNGT2GeneProduct2793 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
IP3MetaboliteHMDB0001143 (HMDB)
ITPR1GeneProduct3708 (Entrez Gene)
KCNJ3GeneProduct3760 (Entrez Gene)
KRASGeneProduct3845 (Entrez Gene)
NRASGeneProduct4893 (Entrez Gene)
PDE1AGeneProduct5136 (Entrez Gene)
PDE1BGeneProduct5153 (Entrez Gene)
PDE1CGeneProduct5137 (Entrez Gene)
PDE4AGeneProduct5141 (Entrez Gene)
PDE4BGeneProduct5142 (Entrez Gene)
PDE4CGeneProduct5143 (Entrez Gene)
PDE4DGeneProduct5144 (Entrez Gene)
PDE7AGeneProduct5150 (Entrez Gene)
PDE7BGeneProduct27115 (Entrez Gene)
PDE8AGeneProduct5151 (Entrez Gene)
PDE8BGeneProduct8622 (Entrez Gene)
PLCB3GeneProduct5331 (Entrez Gene)
PPP3CAGeneProduct5530 (Entrez Gene)
PPP3CCGeneProduct5533 (Entrez Gene)
PRKACAGeneProduct5566 (Entrez Gene)
PRKACBGeneProduct5567 (Entrez Gene)
PRKACGGeneProduct5568 (Entrez Gene)
PRKAR1AGeneProduct5573 (Entrez Gene)
PRKAR1BGeneProduct5575 (Entrez Gene)
PRKAR2AGeneProduct5576 (Entrez Gene)
PRKAR2BGeneProduct5577 (Entrez Gene)
PRKCAGeneProduct5578 (Entrez Gene)
PRKCB1GeneProduct5579 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PRKCEGeneProduct5581 (Entrez Gene)
PRKCGGeneProduct5582 (Entrez Gene)
PRKCHGeneProduct5583 (Entrez Gene)
PRKCIGeneProduct5584 (Entrez Gene)
PRKCQGeneProduct5588 (Entrez Gene)
PRKCZGeneProduct5590 (Entrez Gene)
PRKD1GeneProduct5587 (Entrez Gene)
PRKD3GeneProduct23683 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene)
RRASGeneProduct6237 (Entrez Gene)
SLC9A1GeneProduct6548 (Entrez Gene)
cAMPMetaboliteHMDB0000058 (HMDB)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP35"
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