Matrix metalloproteinases (Mus musculus)

From WikiPathways

Revision as of 20:30, 26 February 2025 by Khanspers (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Based on Vu & Werb (2000)Matrix metalloproteinases: effectors ofdevelopment and normal physiology.Genes Dev 14:2123-2133CollagenasesMmp1aMmp8Mmp13GelatinasesMmp2Mmp9StromelysinsMmp10Mmp3Mmp11Membrane-type MMPsMmp14Mmp15Mmp16Mmp17Mmp24Mmp25OtherMmp19Mmp28MMP23AMmp27Mmp21Mmp23EnamelysinMmp20MatrilysinMmp7MMP26MetalloelastaseMmp12InhibitorsTimp2Timp3Timp4Timp1Potential Inducers of TranscriptionBsgTnfTcf20Name: Matrix metalloproteinasesOrganism: Mus musculus


Description

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily.

Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense.

Source: [Wikipedia](https://en.wikipedia.org/wiki/Matrix_metalloproteinase)

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP129(r20953) with a 93% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Image:NonTypical.pngAnnotated lists
Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes
Homology Converted

Ontology Terms

Bibliography

  1. Vu TH, Werb Z; ''Matrix metalloproteinases: effectors of development and normal physiology.''; Genes Dev, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137002
Approved
view20:30, 26 February 2025KhanspersModified description
117913view10:33, 23 May 2021EweitzModified title
69114view18:13, 8 July 2013MaintBotUpdated to 2013 gpml schema
67453view11:03, 26 June 2013DdiglesOntology Term : 'cell-extracellular matrix signaling pathway' added !
41300view00:23, 2 March 2011MaintBotRemoved redundant pathway information and comments
35331view08:32, 12 February 2010ThomasModified description
35329view08:31, 12 February 2010Thomasmoved reference from comments to bibliography
34566view21:40, 21 December 2009Khansperslayout and description
34565view21:39, 21 December 2009KhanspersModified description
32432view17:14, 15 August 2009MaintBotFixed text labels
32100view13:45, 14 August 2009MaintBotFixed group labels
31453view21:12, 13 August 2009MaintBotFixed text labels
30892view00:21, 30 July 2009MaintBotConverted from Homo sapiens
21608view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Matrix Metalloproteinases]] moved to [[Pathway:WP441]]: Moved to stable identifier
8256view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Matrix Metalloproteinases]] moved to [[Pathway:Mus musculus:Matrix Metalloproteinases]]: Renaming species
7748view16:15, 18 December 2007MaintBotfixed category names
7429view12:42, 4 November 2007MaintBotAdded categories to GPML
19509view22:19, 22 May 2007M.Braymergpml file for [[Mouse:Matrix_Metalloproteinases]]
6475view22:19, 22 May 2007Kdahlquistgpml file for [[Mouse:Matrix_Metalloproteinases]]

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
BsgGeneProduct12215 (Entrez Gene)
MMP23AGeneProduct
MMP26GeneProduct
Mmp10GeneProduct17384 (Entrez Gene)
Mmp11GeneProduct17385 (Entrez Gene)
Mmp12GeneProduct17381 (Entrez Gene)
Mmp13GeneProduct17386 (Entrez Gene)
Mmp14GeneProduct17387 (Entrez Gene)
Mmp15GeneProduct17388 (Entrez Gene)
Mmp16GeneProduct17389 (Entrez Gene)
Mmp17GeneProduct23948 (Entrez Gene)
Mmp19GeneProduct58223 (Entrez Gene)
Mmp1aGeneProduct83995 (Entrez Gene)
Mmp20GeneProduct30800 (Entrez Gene)
Mmp21GeneProduct214766 (Entrez Gene)
Mmp2GeneProduct17390 (Entrez Gene)
Mmp23GeneProduct26561 (Entrez Gene)
Mmp24GeneProduct17391 (Entrez Gene)
Mmp25GeneProduct240047 (Entrez Gene)
Mmp27GeneProduct234911 (Entrez Gene)
Mmp28GeneProduct118453 (Entrez Gene)
Mmp3GeneProduct17392 (Entrez Gene)
Mmp7GeneProduct17393 (Entrez Gene)
Mmp8GeneProduct17394 (Entrez Gene)
Mmp9GeneProduct17395 (Entrez Gene)
Tcf20GeneProduct21411 (Entrez Gene)
Timp1GeneProduct21857 (Entrez Gene)
Timp2GeneProduct21858 (Entrez Gene)
Timp3GeneProduct21859 (Entrez Gene)
Timp4GeneProduct110595 (Entrez Gene)
TnfGeneProduct21926 (Entrez Gene)

Annotated Interactions

No annotated interactions
Personal tools