IL23 inhibitors in inflammatory bowel disease (Homo sapiens)

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Description

IL-23 is a two-part cytokine that differs in structure and function from IL-12. It was initially identified when the p19 subunit was found to pair with p40, triggering the STAT4–JAK2 signaling pathway. Typically, macrophages, neutrophils, and dendritic cells produce IL-23 via TLR4 stimulation, and intestinal epithelial cells have also been shown to contribute. Inspired by [figure 1, Bourgonje 2025](https://www.gastrojournal.org/article/S0016-5085(24)05124-2/fulltext).

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bourgonje AR, Ungaro RC, Mehandru S, Colombel JF; ''Targeting the Interleukin 23 Pathway in Inflammatory Bowel Disease.''; Gastroenterology, 2025 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
140901view11:08, 30 October 2025EweitzClear deprecated metadata rendering
139168view12:32, 24 May 2025EweitzTrigger SVG regeneration without redundant metadata
138830view09:34, 4 May 2025EgonwRemoved the Ensembl datasource (does not seem to be a gene)
137255view12:57, 1 March 2025EweitzOntology Term : 'gamma-delta T cell' added !
137254view12:57, 1 March 2025EweitzOntology Term : 'group 3 innate lymphoid cell, human' added !
137253view12:56, 1 March 2025EweitzModified description
137252view12:40, 1 March 2025EweitzLabel tissues, general immune cell
137246view12:22, 1 March 2025EweitzOntology Term : 'ulcerative colitis' added !
137245view12:21, 1 March 2025EweitzOntology Term : 'Crohn's disease' added !
137244view12:20, 1 March 2025EweitzModified description
137243view12:18, 1 March 2025EweitzModified description
137240view11:53, 1 March 2025EweitzOntology Term : 'drug pathway' added !
137239view11:53, 1 March 2025EweitzOntology Term : 'interleukin-23 signaling pathway' added !
137238view11:52, 1 March 2025EweitzModified description
137237view11:52, 1 March 2025EweitzModified description
137236view11:51, 1 March 2025EweitzModified description
137235view11:37, 1 March 2025EweitzModified description
137234view11:36, 1 March 2025EweitzAdd literature reference
137215view02:11, 1 March 2025EweitzOntology Term : 'inflammatory bowel disease' added !
137214view02:10, 1 March 2025EweitzOntology Term : 'T-helper 17 cell' added !
137213view02:07, 1 March 2025EweitzOntology Term : 'neutrophil' added !
137212view02:07, 1 March 2025EweitzOntology Term : 'dendritic cell' added !
137211view02:07, 1 March 2025EweitzOntology Term : 'macrophage' added !
137210view02:06, 1 March 2025EweitzOntology Term : 'intestinal epithelial cell' added !
137209view02:05, 1 March 2025EweitzIdentify drugs, label nucleus
137208view01:56, 1 March 2025EweitzAdd gene identifiers
137207view00:44, 1 March 2025EweitzExpand acronym, refine graphics
137187view12:02, 28 February 2025EweitzUse gene names; "AP" -> "antigen presentation", fix node type
137186view11:53, 28 February 2025EweitzSplit proliferation from genes, link only from Th17
137178view04:07, 28 February 2025EweitzIdentify more nodes
137177view03:59, 28 February 2025EweitzUse gene symbols, identify p19 and p40 key nodes
137176view03:50, 28 February 2025EweitzRevise group to complex
137175view03:27, 28 February 2025EweitzAdd inflammatory bowel disease, align nodes
137174view03:20, 28 February 2025EweitzEconomize layout
137173view03:12, 28 February 2025EweitzAdd catalysis, segment group
137172view03:01, 28 February 2025EweitzImprove grouping
137171view02:55, 28 February 2025EweitzRefine ordering, node layout
137170view02:45, 28 February 2025EweitzRefine node layout, add interactions
137169view02:32, 28 February 2025EweitzSimplify global flow
137168view02:01, 28 February 2025EweitzAdd interactions, refine layering
137167view01:49, 28 February 2025EweitzAdd interactions, complexes
137166view01:06, 28 February 2025EweitzModified description
137081view18:09, 27 February 2025AlexanderPicoModified description
137078view05:41, 27 February 2025EgonwModified description
137076view05:00, 27 February 2025EweitzAdd microbes, start interactions
137075view04:53, 27 February 2025EweitzAdd output nodes for target cells
137074view04:19, 27 February 2025EweitzAdd more cell types, arrange nodes
137073view04:05, 27 February 2025EweitzAdd some cell types, glycocalyx
137071view03:35, 27 February 2025EweitzAdd drugs
137070view03:29, 27 February 2025EweitzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AMPsGeneProduct
APGeneProduct
BrazikumabMetabolite
CytokinesGeneProduct
GM-CSFGeneProduct
Glycocalyx
GuselkumabMetabolite
IFNGGeneProduct
IL12RB1GeneProduct
IL17AGeneProduct
IL17FGeneProduct
IL22GeneProduct
IL23GeneProduct
IL23RAGeneProduct
JAK2GeneProduct
Luminal contentMetabolite
Maturation
MirikizumabMetabolite
Phagocytosis
Proliferation
RORGTGeneProduct
RisankizumabMetabolite
STAT1GeneProduct
STAT3GeneProduct
STAT4GeneProduct
STAT5GeneProduct
TLR4GeneProduct
TNFAGeneProduct
TYK2GeneProduct
p19GeneProduct
p40GeneProduct

Annotated Interactions

No annotated interactions

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