MSMP expression regulation in cancer cells and its pro-angiogenic role in ovarian tumors (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none EnhancerTumor cellNucleusEndothelial cellMAPK signalingCCR2AngiogenesisMSMPCTCFCCR2MSMPHypoxiaName: MSMP expression regulation in cancer cells and its pro-angiogenic role in ovarian tumorsOrganism: Homo sapiens


Description

Proposed model for regulation of MSMP expression in cancer cells under hypoxic conditions and the proangiogenic role of MSMP in ovarian tumors.

The recruitment of the transcriptional repressor CTCF to the MSMP enhancer region is regulated by changes in H3 acetylation of the MSMP enhancer. In hypoxic conditions, the repressor-enhancer binding is disrupted, leading to increased expression of MSMP. Secretion of MSMP triggers MAPK signaling in endothelial cells (presumably via CCR2 signaling), which promotes angiogenesis.

This suggests that MSMP inhibition in combination with antiangiogenesis drugs (anti-VEGF) could be a new strategy to overcome resistance to antiangiogenesis therapy.

Description adapted from Mitamura et al.

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Quality Tags

Image:Curated.pngReview changes for Approved
Image:Wplogo_31.pngCommunity: CPTAC

Ontology Terms

 

Bibliography

  1. Mitamura T, Pradeep S, McGuire M, Wu SY, Ma S, Hatakeyama H, Lyons YA, Hisamatsu T, Noh K, Villar-Prados A, Chen X, Ivan C, Rodriguez-Aguayo C, Hu W, Lopez-Berestein G, Coleman RL, Sood AK; ''Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP).''; Oncogene, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137392
Approved
view23:21, 1 March 2025EweitzRefine cell and nucleus size, layering
137391view23:19, 1 March 2025EweitzRefine labels for cell types, nucleus
137390view23:17, 1 March 2025EweitzEconomize layout
137389view23:15, 1 March 2025EweitzModified title
128734view03:02, 21 February 2024EweitzOntology Term : 'neoplastic cell' added !
128733view03:01, 21 February 2024EweitzUpgrade disease node, standardize case
123433
CPTAC
view04:35, 27 July 2022EgonwMade two pathways clickable
108140view10:33, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
98987view20:37, 19 October 2018KhanspersModified description
98986view20:37, 19 October 2018KhanspersModified description
98985view20:27, 19 October 2018KhanspersOntology Term : 'endothelial cell' added !
98984view20:27, 19 October 2018KhanspersOntology Term : 'CC chemokine mediated signaling pathway' added !
98983view20:25, 19 October 2018KhanspersOntology Term : 'ovarian cancer' added !
98982view20:24, 19 October 2018KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AngiogenesisPathwayWP1539 (WikiPathways)
CCR2GeneProductENSG00000121807 (Ensembl)
CTCFGeneProductENSG00000102974 (Ensembl)
HypoxiaQ105688 (Wikidata)
MAPK signalingPathwayWP382 (WikiPathways)
MSMPGeneProductENSG00000215183 (Ensembl)

Annotated Interactions

No annotated interactions

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