Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity (Homo sapiens)

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Description

New Adverse Outcome Pathway

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Quality Tags

Ontology Terms

 

Bibliography

  1. Dierichs NTOM, Piersma AH, Peeters RP, Visser WE, Meima ME, Hessel EVS; ''Mechanisms of developmental neurotoxicity mediated by perturbed thyroid hormone homeostasis in the brain: an adverse outcome pathway network.''; Crit Rev Toxicol, 2025 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
138127view15:43, 16 March 2025Marvin M2Added reference to main paper
137486view21:47, 2 March 2025Marvin M2Ontology Term : 'oligodendrocyte' added !
137485view21:47, 2 March 2025Marvin M2Ontology Term : 'neuron' added !
137484view21:46, 2 March 2025Marvin M2Ontology Term : 'neurodevelopmental disorder pathway' added !
137483view21:45, 2 March 2025Marvin M2Ontology Term : 'DOID:1561' removed !
137482view21:45, 2 March 2025Marvin M2Ontology Term : 'cognitive disorder' added !
137481view21:44, 2 March 2025Marvin M2Modified description
137480view21:40, 2 March 2025Marvin M2New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Abnormal white matterKey Event
Altered myelin gene expressionKey Event
BDNF signaling pathwayPathwayWP2380 (WikiPathways)
Cell cyclePathwayWP179 (WikiPathways)
Decreased T3/T4 availabilityKey Event280 (AOP-Wiki KE)
Decreased axon insulationKey Event
Decreased cell proliferationKey Event
Decreased cognition
Decreased membrane transport of T3Key Event
Decreased motor function
Decreased network formationKey Event
Decreased neural network communication
Decreased synaptogenesis Key Event385 (AOP-Wiki KE)
Hippocampal synaptogenesis and neurogenesisPathwayWP5231 (WikiPathways)
Hypomyelination2107 (AOP-Wiki KE)
Oligodendrocyte specification and differentiation, leading to myelin components for CNSPathwayWP4304 (WikiPathways)
Reduced activation TRa1Key Event
Reduced levels of BDNF Key Event381 (AOP-Wiki KE)
Reduced levels of intracellular T3Key Event
SLC16A10GeneProduct117247 (Entrez Gene)
SLC16A2GeneProduct6567 (Entrez Gene)
SLC7A5GeneProduct8140 (Entrez Gene)
SLC7A8GeneProduct23428 (Entrez Gene)
SLCO1A2GeneProduct6579 (Entrez Gene)
SLCO1C1GeneProduct53919 (Entrez Gene)
SLCO3A1GeneProduct28232 (Entrez Gene)
SLCO4A1GeneProduct28231 (Entrez Gene)

Annotated Interactions

No annotated interactions

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