Adipogenesis (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none PreadipocyteDifferentiated adipocyteInhibitors of Preadipocyte to Adipocyte TransitionWNT10BDLK1GATA3GATA2NDNWNT5BWNT1GATA4Transcription Factors/ModulatorsPPARDCREB1CEBPBRXRARARANR1H3SREBF1PPARGMEF2AMEF2BMEF2CMEF2DCEBPDNCOA1PPARAMBNL1RXRGNR2F1NRIP1RORANCOR1NCOR2CEBPAMiscellaneous FactorsPTGISMIXL1ID3STAT5ASTAT5BDDIT3LIFCYP26A1CYP26B1RBL1ASIPMIFSERPINE1SCDTWIST1RB1RBL2CDKN1AE2F1SP1HMGA1GADD45AGADD45BBMP1BMP2BMP3BMP4FOXO1AKLF5FOXC2NCOA2STAT3STAT2STAT1STAT6SOCS1SOCS3CNTFRLIFRIL6STOSMCTNNB1SMAD3FZD1DVL1TCF1FRZBTRIB3CUGBP1HIF1AKLF6KLF7SFRP4KLF15EGR2EBFEPAS1AHRC10orf70WWTR1GDF10PCK1PCK2E2F4Adipocyte Secretory ProductsTNFLEPRETNDFADIPOQADFPAGTIL6PBEF1SPOCKADPNInsulin Action GenesIRS1IRS4IRS2IRS3PPossible Lipodystrophy GenesBSCL2LMNAAGPAT2ZMPSTE24LPIN1LPIN2LPIN3Fully DifferentiatedAdipocyte MarkersLPLFASSLC2A4GTF3APLINPPARGC1AUCP1LIPEGrowth Factors/HormonesIGF1GH1NR3C1TGFB1INSPRLRName: AdipogenesisOrganism: Homo sapiens


Description

The different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from preadipocytes to adipocytes (fat cells). Adipose tissue, composed of white and brown adipose tissue, is composed of adipocytes. This pathway is primarily studied to understand factors that contribute to obesity and diabetes. Transcriptional and hormonal regulators of adipocyte formation are indicated.

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP236)

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Quality Tags

Image:NonTypical.pngAnnotated lists
Image:Curated.pngReview changes for Approved

Ontology Terms

Cell Type : adipocyte preadipocyte
 

Bibliography

  1. Rosen ED, Spiegelman BM; ''Molecular regulation of adipogenesis.''; Annu Rev Cell Dev Biol, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137856
Approved
view14:57, 8 March 2025EweitzStandardize case
137855view14:56, 8 March 2025EweitzFix truncated text
137854view14:55, 8 March 2025EweitzEconomize layout
137853view14:53, 8 March 2025EweitzTailor node width
137852view14:51, 8 March 2025EweitzEconomize layout
137851view14:48, 8 March 2025EweitzEconomize layout
137850view14:40, 8 March 2025EweitzIncrease font size
137849view14:38, 8 March 2025EweitzOntology Term : 'adipocyte' added !
137789view06:24, 8 March 2025EgonwModified description
105873view04:49, 16 August 2019KhanspersModified description
105434view04:34, 8 August 2019KhanspersModified description
97606view12:17, 29 May 2018AMTanOntology Term : 'preadipocyte' added !
97605view12:16, 29 May 2018AMTanModified description
80209view21:01, 22 May 2015KhanspersReverted to version '14:50, 7 January 2015' by Khanspers
80192view22:41, 19 May 2015Khanspersadded mir451a target interaction with MIF
78584view14:50, 7 January 2015MaintBotadded missing graphIds
72082view20:47, 24 October 2013AlexanderPicoIRS3L is discontinued; now called IRS3P
63139view19:17, 8 May 2013MaintBotUpdating GPML version
44941view12:29, 6 October 2011MartijnVanIerselOntology Term : 'signaling pathway pertinent to development' added !
41040view23:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
38920view21:07, 24 September 2010Khanspers
35341view08:54, 12 February 2010MartijnVanIerselModified description
35012view19:45, 10 February 2010NsalomonisGrouped objects
35011view19:41, 10 February 2010NsalomonisAdded review reference
35010view19:40, 10 February 2010NsalomonisModified description
28133view19:47, 27 January 2009KhanspersRemoved species from pathway name
21173view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Adipogenesis]] moved to [[Pathway:WP236]]: Moved to stable identifier
12938view10:42, 17 May 2008MaintBotSticky edges patch by Sjoerd
7884view13:46, 7 January 2008MaintBot[[Pathway:Human:Adipogenesis]] moved to [[Pathway:Homo sapiens:Adipogenesis]]: Renaming species
7567view16:00, 18 December 2007MaintBotfixed category names
7452view12:42, 4 November 2007MaintBotAdded categories to GPML
6291view22:17, 22 May 2007M.PattiUploaded from wpi.php

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ADFPGeneProduct123 (Entrez Gene)
ADIPOQGeneProduct9370 (Entrez Gene)
ADPNGeneProduct80339 (Entrez Gene)
AGPAT2GeneProduct10555 (Entrez Gene)
AGTGeneProduct183 (Entrez Gene)
AHRGeneProduct196 (Entrez Gene)
ASIPGeneProduct434 (Entrez Gene)
BMP1GeneProduct649 (Entrez Gene)
BMP2GeneProduct650 (Entrez Gene)
BMP3GeneProduct651 (Entrez Gene)
BMP4GeneProduct652 (Entrez Gene)
BSCL2GeneProduct26580 (Entrez Gene)
C10orf70GeneProduct55847 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CEBPAGeneProduct1050 (Entrez Gene)
CEBPBGeneProduct1051 (Entrez Gene)
CEBPDGeneProduct1052 (Entrez Gene)
CNTFRGeneProduct1271 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
CUGBP1GeneProduct10658 (Entrez Gene)
CYP26A1GeneProduct1592 (Entrez Gene)
CYP26B1GeneProduct56603 (Entrez Gene)
DDIT3GeneProduct1649 (Entrez Gene)
DFGeneProduct1675 (Entrez Gene)
DLK1GeneProduct8788 (Entrez Gene)
DVL1GeneProduct1855 (Entrez Gene)
E2F1GeneProduct1869 (Entrez Gene)
E2F4GeneProduct1874 (Entrez Gene)
EBFGeneProduct1879 (Entrez Gene)
EGR2GeneProduct1959 (Entrez Gene)
EPAS1GeneProduct2034 (Entrez Gene)
FASGeneProduct355 (Entrez Gene)
FOXC2GeneProduct2303 (Entrez Gene)
FOXO1AGeneProduct2308 (Entrez Gene)
FRZBGeneProduct2487 (Entrez Gene)
FZD1GeneProduct8321 (Entrez Gene)
GADD45AGeneProduct1647 (Entrez Gene)
GADD45BGeneProduct4616 (Entrez Gene)
GATA2GeneProduct2624 (Entrez Gene)
GATA3GeneProduct2625 (Entrez Gene)
GATA4GeneProduct2626 (Entrez Gene)
GDF10GeneProduct2662 (Entrez Gene)
GH1GeneProduct2688 (Entrez Gene)
GTF3AGeneProduct2971 (Entrez Gene)
HIF1AGeneProduct3091 (Entrez Gene)
HMGA1GeneProduct3159 (Entrez Gene)
ID3GeneProduct3399 (Entrez Gene)
IGF1GeneProduct3479 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL6STGeneProduct3572 (Entrez Gene)
INSGeneProduct3630 (Entrez Gene)
IRS1GeneProduct3667 (Entrez Gene)
IRS2GeneProduct8660 (Entrez Gene)
IRS3PGeneProduct442338 (Entrez Gene)
IRS4GeneProduct8471 (Entrez Gene)
KLF15GeneProduct28999 (Entrez Gene)
KLF5GeneProduct688 (Entrez Gene)
KLF6GeneProduct1316 (Entrez Gene)
KLF7GeneProduct8609 (Entrez Gene)
LEPGeneProduct3952 (Entrez Gene)
LIFGeneProduct3976 (Entrez Gene)
LIFRGeneProduct3977 (Entrez Gene)
LIPEGeneProduct3991 (Entrez Gene)
LMNAGeneProduct4000 (Entrez Gene)
LPIN1GeneProduct23175 (Entrez Gene)
LPIN2GeneProduct9663 (Entrez Gene)
LPIN3GeneProduct64900 (Entrez Gene)
LPLGeneProduct4023 (Entrez Gene)
MBNL1GeneProduct4154 (Entrez Gene)
MEF2AGeneProduct4205 (Entrez Gene)
MEF2BGeneProduct4207 (Entrez Gene)
MEF2CGeneProduct4208 (Entrez Gene)
MEF2DGeneProduct4209 (Entrez Gene)
MIFGeneProduct4282 (Entrez Gene)
MIXL1GeneProduct83881 (Entrez Gene)
NCOA1GeneProduct8648 (Entrez Gene)
NCOA2GeneProduct10499 (Entrez Gene)
NCOR1GeneProduct9611 (Entrez Gene)
NCOR2GeneProduct9612 (Entrez Gene)
NDNGeneProduct4692 (Entrez Gene)
NR1H3GeneProduct10062 (Entrez Gene)
NR2F1GeneProduct7025 (Entrez Gene)
NR3C1GeneProduct2908 (Entrez Gene)
NRIP1GeneProduct8204 (Entrez Gene)
OSMGeneProduct5008 (Entrez Gene)
PBEF1GeneProduct10135 (Entrez Gene)
PCK1GeneProduct5105 (Entrez Gene)
PCK2GeneProduct5106 (Entrez Gene)
PLINGeneProduct5346 (Entrez Gene)
PPARAGeneProduct5465 (Entrez Gene)
PPARDGeneProduct5467 (Entrez Gene)
PPARGGeneProduct5468 (Entrez Gene)
PPARGC1AGeneProduct10891 (Entrez Gene)
PRLRGeneProduct5618 (Entrez Gene)
PTGISGeneProduct5740 (Entrez Gene)
RARAGeneProduct5914 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
RBL1GeneProduct5933 (Entrez Gene)
RBL2GeneProduct5934 (Entrez Gene)
RETNGeneProduct56729 (Entrez Gene)
RORAGeneProduct6095 (Entrez Gene)
RXRAGeneProduct6256 (Entrez Gene)
RXRGGeneProduct6258 (Entrez Gene)
SCDGeneProduct6319 (Entrez Gene)
SERPINE1GeneProduct5054 (Entrez Gene)
SFRP4GeneProduct6424 (Entrez Gene)
SLC2A4GeneProduct6517 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SOCS1GeneProduct8651 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
SP1GeneProduct6667 (Entrez Gene)
SPOCKGeneProduct6695 (Entrez Gene)
SREBF1GeneProduct6720 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT2GeneProduct6773 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
STAT5AGeneProduct6776 (Entrez Gene)
STAT5BGeneProduct6777 (Entrez Gene)
STAT6GeneProduct6778 (Entrez Gene)
TCF1GeneProduct6927 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TRIB3GeneProduct57761 (Entrez Gene)
TWIST1GeneProduct7291 (Entrez Gene)
UCP1GeneProduct7350 (Entrez Gene)
WNT10BGeneProduct7480 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
WNT5BGeneProduct81029 (Entrez Gene)
WWTR1GeneProduct25937 (Entrez Gene)
ZMPSTE24GeneProduct10269 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP236"
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