Psoriasis mechanism and therapies (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none IL-23+ CD14+dendritic cella.k.a. PSORS1Munro's microabscessNeutrophilIL12BUstekinumabEnvironmental stressTraumaHLA-CIL23AIL17AIL17FTYK2IL12RB1IL23RJAK2STAT3IL22CCR6CCL20CXCL8CXCL1IL18TNFIL23AIL23AGuselkumabRisankizumabSecukinumabIxekizumabBimekizumabBrodalumabDeucravacitinibBrepocitinibIL-17-producing cell(Th17, Tc17, ILC3)IL17RCKeratinocyteName: Immunotherapies for psoriasisOrganism: Homo sapiens


Description

No description

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Quality Tags

Ontology Terms

Pathway Ontology : base excision repair pathway
 

Bibliography

  1. Song A, Lee SE, Kim JH; ''Immunopathology and Immunotherapy of Inflammatory Skin Diseases.''; Immune Netw, 2022 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
139165view12:24, 24 May 2025EweitzTrigger SVG regeneration without redundant metadata
139010view21:05, 10 May 2025EweitzModified title
138828view01:49, 4 May 2025EweitzRefine layering
138827view01:35, 4 May 2025EweitzAdd identifiers for drugs
138826view01:27, 4 May 2025EweitzModified description
138825view01:21, 4 May 2025EweitzModified description
138824view01:20, 4 May 2025EweitzModified description
138823view01:19, 4 May 2025EweitzAdd literature reference
138822view01:18, 4 May 2025EweitzOntology Term : 'drug pathway' added !
138821view01:18, 4 May 2025EweitzOntology Term : 'psoriasis' added !
138820view01:17, 4 May 2025EweitzOntology Term : 'group 3 innate lymphoid cell' added !
138819view01:16, 4 May 2025EweitzOntology Term : 'Tc17 cell' added !
138818view01:16, 4 May 2025EweitzOntology Term : 'T-helper 17 cell' added !
138817view01:15, 4 May 2025EweitzOntology Term : 'dendritic cell' added !
138816view01:15, 4 May 2025EweitzRefine keratinocyte graphics
138815view01:09, 4 May 2025EweitzModified title
138814view01:07, 4 May 2025EweitzModified description
138813view00:59, 4 May 2025EweitzOntology Term : 'neutrophil' added !
138812view00:58, 4 May 2025EweitzOntology Term : 'keratinocyte' added !
138811view00:57, 4 May 2025EweitzEconomize layout
138810view00:49, 4 May 2025EweitzRefine interaction position, label, dimensions
138809view00:47, 4 May 2025EweitzEconomize layout
138808view00:46, 4 May 2025EweitzAdd interactions
138807view00:41, 4 May 2025EweitzAdd interactions
138806view00:21, 4 May 2025EweitzEconomize layout
138805view00:17, 4 May 2025EweitzAdd interactions
138804view00:07, 4 May 2025EweitzFix PFOCR error: IL1B, not IL18
138803view00:03, 4 May 2025EweitzAdd interactions
138802view19:51, 3 May 2025EweitzAdd interactions
138801view19:43, 3 May 2025EweitzMove cells closer
138800view19:37, 3 May 2025EweitzRefine cell graphics
138799view19:36, 3 May 2025EweitzAdd epidermis
138798view19:12, 3 May 2025EweitzAdd interactions
138797view18:58, 3 May 2025EweitzArrange cells, genes
138796view18:54, 3 May 2025EweitzColor IL-17-producing cell set
138795view18:50, 3 May 2025EweitzAdd dermis cell set
138794view18:44, 3 May 2025EweitzRefine cell type colors
138793view18:39, 3 May 2025EweitzAdd Munro's microabscess, color cell types
138792view18:24, 3 May 2025EweitzAdd cell types, conditions
138791view17:53, 3 May 2025EweitzAdd pharmaceutical therapy metabolite nodes
138790view17:38, 3 May 2025EweitzCorrect genes; context: https://github.com/wikipathways/wikipathways-help/discussions/165
138789view14:29, 3 May 2025EweitzArrange genes
138788view14:17, 3 May 2025EweitzNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
BimekizumabMetabolite
BrepocitinibMetabolite
BrodalumabMetabolite
CCL20GeneProduct6364 (Entrez Gene) OCR lexicon match: CCL20
CCR6GeneProduct1235 (Entrez Gene) OCR lexicon match: CCR6
CXCL1GeneProduct2919 (Entrez Gene) OCR lexicon match: CXCL1
CXCL8GeneProduct3576 (Entrez Gene) OCR lexicon match: CXCL8
DeucravacitinibMetabolite
Environmental stress
GuselkumabMetabolite
HLA-CGeneProduct3107 (Entrez Gene) OCR lexicon match: PSORS1
IL12BGeneProductENSG00000113302 (Ensembl) "IL-23" originally
IL12RB1GeneProduct3594 (Entrez Gene) OCR lexicon match: IL12RB
IL17AGeneProduct3605 (Entrez Gene) OCR lexicon match: IL-17A
IL17FGeneProduct112744 (Entrez Gene) OCR lexicon match: IL-17F
IL17RCGeneProductENSG00000163702 (Ensembl) OCR lexicon match: IL-17A
IL18GeneProduct3606 (Entrez Gene) OCR lexicon match: IL-18
IL22GeneProduct50616 (Entrez Gene) OCR lexicon match: IL-22
IL23AGeneProduct51561 (Entrez Gene) OCR lexicon match: IL-23
IL23AGeneProductENSG00000110944 (Ensembl) "IL-23" originally
IL23RGeneProduct149233 (Entrez Gene) OCR lexicon match: IL23R
IxekizumabMetabolite
JAK2GeneProduct3717 (Entrez Gene) OCR lexicon match: JAK2
RisankizumabMetabolite
STAT3GeneProduct6774 (Entrez Gene) OCR lexicon match: STAT3
SecukinumabMetabolite
TNFGeneProduct7124 (Entrez Gene) OCR lexicon match: TNF-A
TYK2GeneProduct7297 (Entrez Gene) OCR lexicon match: TYK2
Trauma
UstekinumabMetabolite

Annotated Interactions

No annotated interactions

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