Atopic dermatitis mechanism and therapies (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Genetic predispositionTSLPIL25IL33IL4IL13IL5IL1RL1IL31RCRLF2FCER1IGHEJAK3IL2RGIL4RJAK1STAT6IL4RAIL13RA1TYK2STAT3DelgocitinibDupilumabUpadacitinibAbrocitinibBaricitinibRuxolitinibTralokinumabNemolizumabIL31RAOSMRFCER1AFCER1GMS4A2MS4A2Inflammatory dendritic epidermal cell (IDEC)Langerhans cell (LC)FCER1FCER1AFCER1GMS4A2MS4A2Environmental factorsBarrier dysfunctionSkin microbiotaS. aureusName: Atopic dermatitis mechanism and therapiesOrganism: Homo sapiens


Description

No description

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Quality Tags

Ontology Terms

Pathway Ontology : energy metabolic pathway
 

Bibliography

  1. Song A, Lee SE, Kim JH; ''Immunopathology and Immunotherapy of Inflammatory Skin Diseases.''; Immune Netw, 2022 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
139166view12:25, 24 May 2025EweitzTrigger SVG regeneration without redundant metadata
138897view00:20, 7 May 2025EweitzModified description
138893view13:05, 6 May 2025EweitzModified description
138892view13:03, 6 May 2025EweitzAdd literature reference
138891view13:02, 6 May 2025EweitzOntology Term : 'keratinocyte' added !
138890view13:01, 6 May 2025EweitzModified description
138889view13:01, 6 May 2025EweitzModified description
138888view13:01, 6 May 2025EweitzModified description
138887view12:57, 6 May 2025EweitzModified description
138886view12:57, 6 May 2025EweitzModified description
138885view12:54, 6 May 2025EweitzFix PathVisio / Kaavio graphical discrepancy
138884view12:52, 6 May 2025EweitzOntology Term : 'drug pathway' added !
138883view12:52, 6 May 2025EweitzOntology Term : 'atopic dermatitis' added !
138882view12:52, 6 May 2025EweitzOntology Term : 'mast cell' added !
138881view12:52, 6 May 2025EweitzOntology Term : 'basophil' added !
138880view12:51, 6 May 2025EweitzOntology Term : 'eosinophil' added !
138879view12:51, 6 May 2025EweitzOntology Term : 'B cell' added !
138878view12:51, 6 May 2025EweitzOntology Term : 'T follicular helper cell' added !
138877view12:49, 6 May 2025EweitzOntology Term : 'group 2 innate lymphoid cell' added !
138876view12:49, 6 May 2025EweitzOntology Term : 'T-helper 2 cell' added !
138875view12:35, 6 May 2025EweitzOntology Term : 'sensory neuron' added !
138874view12:35, 6 May 2025EweitzOntology Term : 'dendritic cell' added !
138873view12:35, 6 May 2025EweitzOntology Term : 'epidermal cell' added !
138872view12:29, 6 May 2025EweitzOntology Term : 'Langerhans cell' added !
138871view12:27, 6 May 2025EweitzAlign nodes
138870view12:25, 6 May 2025EweitzEconomize layout
138869view12:19, 6 May 2025EweitzAdd nodes, interactions, cell types
138857view03:53, 6 May 2025EweitzAdd interactions
138856view22:50, 5 May 2025EweitzAdd immune cell types
138851view21:34, 5 May 2025EweitzAdd phenotype, microbe nodes
138846view04:00, 5 May 2025EweitzAdd identifiers to drugs
138845view03:56, 5 May 2025EweitzAdd identifiers to genes
138844view03:24, 5 May 2025EweitzUse gene symbols
138843view03:17, 5 May 2025EweitzAdd LC, IDEC cells
138842view03:06, 5 May 2025EweitzUse gene symbols
138841view22:42, 4 May 2025EweitzArrange nodes
138840view16:16, 4 May 2025EweitzAdd drugs
138839view16:06, 4 May 2025EweitzModified title
138838view16:05, 4 May 2025EweitzModified title
138837view16:05, 4 May 2025EweitzModified title
138836view16:04, 4 May 2025EweitzAdd epidermal cells
138835view16:01, 4 May 2025EweitzAdd keratinocytes
138834view13:26, 4 May 2025EweitzNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AbrocitinibMetaboliteDB14973 (DrugBank)
BaricitinibMetaboliteDB11817 (DrugBank)
Barrier dysfunction
CRLF2GeneProductENSG00000292363 (Ensembl) "TSLPR" originally
DelgocitinibMetaboliteDB16133 (DrugBank)
DupilumabMetaboliteDB12159 (DrugBank)
Environmental factors
FCER1AGeneProductENSG00000179639 (Ensembl) "FCER1" in source
FCER1GeneProduct
FCER1GGeneProductENSG00000158869 (Ensembl) "FCER1" in source
Genetic predisposition
IGHEGeneProductENSG00000211891 (Ensembl) "IgE" in source
IL13GeneProductENSG00000169194 (Ensembl)
IL13RA1GeneProductENSG00000131724 (Ensembl)
IL1RL1GeneProductENSG00000115602 (Ensembl) "IL33R" in source
IL25GeneProductENSG00000166090 (Ensembl)
IL2RGGeneProductENSG00000147168 (Ensembl) "CD132" in source
IL31RAGeneProductENSG00000164509 (Ensembl)
IL31RGeneProduct
IL33GeneProductENSG00000137033 (Ensembl)
IL4GeneProductENSG00000113520 (Ensembl)
IL4RAGeneProduct
IL4RGeneProductENSG00000077238 (Ensembl) "IL4RA" in source
IL5GeneProductENSG00000113525 (Ensembl)
JAK1GeneProduct
JAK3GeneProductENSG00000105639 (Ensembl)
MS4A2GeneProductENSG00000149534 (Ensembl) "FCER1" in source
NemolizumabMetaboliteDB15252 (DrugBank)
OSMRGeneProductENSG00000145623 (Ensembl)
RuxolitinibMetaboliteDB08877 (DrugBank)
S. aureus
STAT3GeneProductENSG00000168610 (Ensembl)
STAT6GeneProductENSG00000166888 (Ensembl)
Skin microbiota
TSLPGeneProductENSG00000145777 (Ensembl)
TYK2GeneProductENSG00000105397 (Ensembl)
TralokinumabMetaboliteDB12169 (DrugBank)
UpadacitinibMetaboliteDB15091 (DrugBank)

Annotated Interactions

No annotated interactions

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