Atopic dermatitis mechanism and therapies (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none JAK3IL2RGIL4RJAK1STAT6Skin microbiotaS. aureusS. epidermidisAllergenTh2 cellILC2Tfh2 cellType IreceptorTSLPIL25IL33Genetic predispositionEnvironmental factorsIL4IL13IL5IGHEIL4RIL13RA1TYK2STAT3JAK1DelgocitinibDupilumabUpadacitinibAbrocitinibBaricitinibRuxolitinibTralokinumabNemolizumabInflammatory dendritic epidermal cell (IDEC)Langerhans cell (LC)Barrier dysfunctionB cellBasophilMast cellEosinophilSensoryneuronIL1RL1CRLF2ItchScratchBarrier dysfunctionFCER1AFCER1GMS4A2MS4A2FCER1AFCER1GMS4A2MS4A2IGHEKeratinocyteB cellSensoryneuronType IIreceptorDEFB103ADEFB103BIL31RAOSMRName: Atopic dermatitis mechanism and therapiesOrganism: Homo sapiens


Description

No description

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Quality Tags

Image:Curated.pngReview changes for Approved

Ontology Terms

Pathway Ontology : regulatory pathway
 

Bibliography

  1. Song A, Lee SE, Kim JH; ''Immunopathology and Immunotherapy of Inflammatory Skin Diseases.''; Immune Netw, 2022 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
139166
Approved
view12:25, 24 May 2025EweitzTrigger SVG regeneration without redundant metadata
138897view00:20, 7 May 2025EweitzModified description
138893view13:05, 6 May 2025EweitzModified description
138892view13:03, 6 May 2025EweitzAdd literature reference
138891view13:02, 6 May 2025EweitzOntology Term : 'keratinocyte' added !
138890view13:01, 6 May 2025EweitzModified description
138889view13:01, 6 May 2025EweitzModified description
138888view13:01, 6 May 2025EweitzModified description
138887view12:57, 6 May 2025EweitzModified description
138886view12:57, 6 May 2025EweitzModified description
138885view12:54, 6 May 2025EweitzFix PathVisio / Kaavio graphical discrepancy
138884view12:52, 6 May 2025EweitzOntology Term : 'drug pathway' added !
138883view12:52, 6 May 2025EweitzOntology Term : 'atopic dermatitis' added !
138882view12:52, 6 May 2025EweitzOntology Term : 'mast cell' added !
138881view12:52, 6 May 2025EweitzOntology Term : 'basophil' added !
138880view12:51, 6 May 2025EweitzOntology Term : 'eosinophil' added !
138879view12:51, 6 May 2025EweitzOntology Term : 'B cell' added !
138878view12:51, 6 May 2025EweitzOntology Term : 'T follicular helper cell' added !
138877view12:49, 6 May 2025EweitzOntology Term : 'group 2 innate lymphoid cell' added !
138876view12:49, 6 May 2025EweitzOntology Term : 'T-helper 2 cell' added !
138875view12:35, 6 May 2025EweitzOntology Term : 'sensory neuron' added !
138874view12:35, 6 May 2025EweitzOntology Term : 'dendritic cell' added !
138873view12:35, 6 May 2025EweitzOntology Term : 'epidermal cell' added !
138872view12:29, 6 May 2025EweitzOntology Term : 'Langerhans cell' added !
138871view12:27, 6 May 2025EweitzAlign nodes
138870view12:25, 6 May 2025EweitzEconomize layout
138869view12:19, 6 May 2025EweitzAdd nodes, interactions, cell types
138857view03:53, 6 May 2025EweitzAdd interactions
138856view22:50, 5 May 2025EweitzAdd immune cell types
138851view21:34, 5 May 2025EweitzAdd phenotype, microbe nodes
138846view04:00, 5 May 2025EweitzAdd identifiers to drugs
138845view03:56, 5 May 2025EweitzAdd identifiers to genes
138844view03:24, 5 May 2025EweitzUse gene symbols
138843view03:17, 5 May 2025EweitzAdd LC, IDEC cells
138842view03:06, 5 May 2025EweitzUse gene symbols
138841view22:42, 4 May 2025EweitzArrange nodes
138840view16:16, 4 May 2025EweitzAdd drugs
138839view16:06, 4 May 2025EweitzModified title
138838view16:05, 4 May 2025EweitzModified title
138837view16:05, 4 May 2025EweitzModified title
138836view16:04, 4 May 2025EweitzAdd epidermal cells
138835view16:01, 4 May 2025EweitzAdd keratinocytes
138834view13:26, 4 May 2025EweitzNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AbrocitinibMetaboliteDB14973 (DrugBank)
AllergenMetaboliteCHEBI:50904 (ChEBI)
BaricitinibMetaboliteDB11817 (DrugBank)
Barrier dysfunction
CRLF2GeneProductENSG00000292363 (Ensembl) "TSLPR" originally
DEFB103AGeneProductENSG00000176797 (Ensembl) "AMPs (e.g., human β-defensin 3) are decreased in keratinocytes in response to IL-4 and IL-13."
DEFB103BGeneProductENSG00000177243 (Ensembl) "AMPs (e.g., human β-defensin 3) are decreased in keratinocytes in response to IL-4 and IL-13."
DelgocitinibMetaboliteDB16133 (DrugBank)
DupilumabMetaboliteDB12159 (DrugBank)
Environmental factors
FCER1AGeneProductENSG00000179639 (Ensembl) "FCER1" in source
FCER1GGeneProductENSG00000158869 (Ensembl) "FCER1" in source
Genetic predisposition
IGHEGeneProductENSG00000211891 (Ensembl) "IgE" in source
IL13GeneProductENSG00000169194 (Ensembl)
IL13RA1GeneProductENSG00000131724 (Ensembl)
IL1RL1GeneProductENSG00000115602 (Ensembl) "IL33R" in source
IL25GeneProductENSG00000166090 (Ensembl)
IL2RGGeneProductENSG00000147168 (Ensembl) "CD132" in source
IL31RAGeneProductENSG00000164509 (Ensembl)
IL33GeneProductENSG00000137033 (Ensembl)
IL4GeneProductENSG00000113520 (Ensembl)
IL4RGeneProductENSG00000077238 (Ensembl) "IL4RA" originally
IL5GeneProductENSG00000113525 (Ensembl)
Itch
JAK1GeneProduct
JAK3GeneProductENSG00000105639 (Ensembl)
MS4A2GeneProductENSG00000149534 (Ensembl) "FCER1" in source
NemolizumabMetaboliteDB15252 (DrugBank)
OSMRGeneProductENSG00000145623 (Ensembl)
RuxolitinibMetaboliteDB08877 (DrugBank)
S. aureus
S. epidermidis
STAT3GeneProductENSG00000168610 (Ensembl)
STAT6GeneProductENSG00000166888 (Ensembl)
Scratch
TSLPGeneProductENSG00000145777 (Ensembl)
TYK2GeneProductENSG00000105397 (Ensembl)
TralokinumabMetaboliteDB12169 (DrugBank)
UpadacitinibMetaboliteDB15091 (DrugBank)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5538"
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