The nucleosome remodelling complex (Homo sapiens)

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Description

The nucleosome remodeling complex

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Ontology Terms

 

Bibliography

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  2. Morozumi Y, Boussouar F, Tan M, Chaikuad A, Jamshidikia M, Colak G, He H, Nie L, Petosa C, de Dieuleveult M, Curtet S, Vitte AL, Rabatel C, Debernardi A, Cosset FL, Verhoeyen E, Emadali A, Schweifer N, Gianni D, Gut M, Guardiola P, Rousseaux S, Gérard M, Knapp S, Zhao Y, Khochbin S; ''Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells.''; J Mol Cell Biol, 2016 PubMed Europe PMC Scholia
  3. Okuwaki M, Kato K, Nagata K; ''Functional characterization of human nucleosome assembly protein 1-like proteins as histone chaperones.''; Genes Cells, 2010 PubMed Europe PMC Scholia
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  6. Liu CP, Xiong C, Wang M, Yu Z, Yang N, Chen P, Zhang Z, Li G, Xu RM; ''Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX.''; Nat Struct Mol Biol, 2012 PubMed Europe PMC Scholia
  7. Tsunaka Y, Fujiwara Y, Oyama T, Hirose S, Morikawa K; ''Integrated molecular mechanism directing nucleosome reorganization by human FACT.''; Genes Dev, 2016 PubMed Europe PMC Scholia
  8. Fard YA, Sadeghi EN, Pajoohesh Z, Gharehdaghi Z, Khatibi DM, Khosravifar S, Pishkari Y, Nozari S, Hijazi A, Pakmehr S, Shayan SK; ''Epigenetic underpinnings of the autistic mind: Histone modifications and prefrontal excitation/inhibition imbalance.''; Am J Med Genet B Neuropsychiatr Genet, 2024 PubMed Europe PMC Scholia
  9. Burgess RJ, Zhang Z; ''Histone chaperones in nucleosome assembly and human disease.''; Nat Struct Mol Biol, 2013 PubMed Europe PMC Scholia
  10. Das C, Roy S, Namjoshi S, Malarkey CS, Jones DN, Kutateladze TG, Churchill ME, Tyler JK; ''Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation.''; Proc Natl Acad Sci U S A, 2014 PubMed Europe PMC Scholia
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  13. Sekulic N, Bassett EA, Rogers DJ, Black BE; ''The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres.''; Nature, 2010 PubMed Europe PMC Scholia
  14. Ho CH, Takizawa Y, Kobayashi W, Arimura Y, Kimura H, Kurumizaka H; ''Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferase.''; Life Sci Alliance, 2021 PubMed Europe PMC Scholia
  15. Ali-Ahmad A, Bilokapić S, Schäfer IB, Halić M, Sekulić N; ''CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail.''; EMBO Rep, 2019 PubMed Europe PMC Scholia
  16. Olley G, Ansari M, Bengani H, Grimes GR, Rhodes J, von Kriegsheim A, Blatnik A, Stewart FJ, Wakeling E, Carroll N, Ross A, Park SM, Bickmore WA, Pradeepa MM, FitzPatrick DR; ''BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome.''; Nat Genet, 2018 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
140344view19:30, 11 August 2025EgonwModified description
140320view10:04, 11 August 2025Fehrhartgraphical updates
140319view10:00, 11 August 2025FehrhartOntology Term : 'epilepsy' added !
140318view09:59, 11 August 2025FehrhartModified description
140202view11:49, 6 August 2025DuanDelete the XRCC6/XRCC5/PRKDC leading to werner syndrome (lack of inclusive evidence).
139715view10:59, 1 July 2025JmlohmannAdded pathway identifiers
139629view10:22, 24 June 2025JmlohmannAdjusted legend.
139626view09:57, 24 June 2025JmlohmannAdded identifier for double-stranded DNA
139625view09:41, 24 June 2025JmlohmannAdjusted CAF and FACT and changed lay-out
139463view03:35, 19 June 2025EgonwOntology Term : 'nucleosome assembly pathway' added !
139462view03:34, 19 June 2025EgonwOntology Term : 'Werner syndrome' added !
139456view14:33, 18 June 2025JmlohmannChecked references and added legend.
139441view12:00, 17 June 2025JmlohmannAdjusted layout
139419view19:10, 16 June 2025JmlohmannNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ASF1AGeneProductENSG00000111875 (Ensembl)
ASF1BGeneProductENSG00000105011 (Ensembl)
CAF-1Complex
CHAF1AGeneProductENSG00000167670 (Ensembl)
CHAF1BGeneProductENSG00000159259 (Ensembl)
CHEK2GeneProductENSG00000183765 (Ensembl)
Cell proliferation
Chromatin (dis)assemblyPathway
DAXXGeneProductENSG00000204209 (Ensembl)
DNA double strand break repair PathwayWP438 (WikiPathways)
DNA replication
Embryonic death at blastula stage
FACTComplex
H2AProteinB2R5B3 (Uniprot-TrEMBL)
H2BProteinB4DR52 (Uniprot-TrEMBL)
H3ProteinB4E380 (Uniprot-TrEMBL)
H4C5GeneProductENSG00000276966 (Ensembl)
H4ProteinP62805 (Uniprot-SwissProt)
HAT1GeneProductENSG00000128708 (Ensembl)
HIRAGeneProduct
Histone chaperone (proteins)
Histone variants
Human Fact and DNA double-strand break (repair)PathwayWP5564 (WikiPathways)
IPO4GeneProductENSG00000196497 (Ensembl)
MCM2GeneProductENSG00000073111 (Ensembl)
NAP1L1GeneProductENSG00000187109 (Ensembl)
NASPGeneProductENSG00000132780 (Ensembl)
NCP formationPathway
Nucleosome assemblyPathway
PCNAGeneProductENSG00000132646 (Ensembl)
PRKDCGeneProductENSG00000253729 (Ensembl)
Proper completion of normal development
RBBP4GeneProductENSG00000162521 (Ensembl)
S-phase progression in cell cyclePathway
SSRP1GeneProductENSG00000149136 (Ensembl)
SUPT16HGeneProductENSG00000092201 (Ensembl)
TEBIVANED-3 (part of thesis)Pathway
XRCC5GeneProductENSG00000079246 (Ensembl)
XRCC6GeneProductENSG00000196419 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5572"
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