Hallmark of Cancer: Resisting cell death through non-genotoxic carcinogenic ROS (Homo sapiens)

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Description

This pathway shows the effect of non-genotoxic reactive oxygen species on inducing the hallmark of cancer: Resisting cell death. To ensure cells that don’t work properly do not cause a problem in our body, cell death is induced in those cells. While there are many different types of cell death, the most common is apoptosis. When cells start showing neoplastic properties, neighbouring cells or immune cells induce apoptosis in those cells. Cancer cells acquire the ability to ignore those signals or simply not receive them.

In this pathway, the pro-apoptotic elements, down-regulated through ROS, are shown in green while the anti-apoptotic elements, up-regulated through ROS, are shown in red. Some proteins showed effects outside of simply inhibiting cell death. This pathway, only shows the effect of ROS on apoptosis as cell death.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Moloney JN, Cotter TG; ''ROS signalling in the biology of cancer.''; Semin Cell Dev Biol, 2018 PubMed Europe PMC Scholia
  2. Qi XJ, Wildey GM, Howe PH; ''Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  3. Niture SK, Jaiswal AK; ''Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance.''; Free Radic Biol Med, 2013 PubMed Europe PMC Scholia
  4. Peña-Blanco A, García-Sáez AJ; ''Bax, Bak and beyond - mitochondrial performance in apoptosis.''; FEBS J, 2018 PubMed Europe PMC Scholia
  5. Phin S, Moore MW, Cotter PD; ''Genomic Rearrangements of PTEN in Prostate Cancer.''; Front Oncol, 2013 PubMed Europe PMC Scholia
  6. Liljie T, DongXiu H, Bo S; ''Nrf2: A critical participant in regulation of apoptosis, ferroptosis, and autophagy in gastric cancer''; Acta Histochemica, 2024
  7. Jiang X, Wang X; ''Cytochrome C-mediated apoptosis.''; Annu Rev Biochem, 2004 PubMed Europe PMC Scholia
  8. McIlwain DR, Berger T, Mak TW; ''Caspase functions in cell death and disease.''; Cold Spring Harb Perspect Biol, 2013 PubMed Europe PMC Scholia
  9. Tsujimoto Y; ''Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria?''; Genes Cells, 1998 PubMed Europe PMC Scholia
  10. Lee SR, Yang KS, Kwon J, Lee C, Jeong W, Rhee SG; ''Reversible inactivation of the tumor suppressor PTEN by H2O2.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  11. Niture SK, Jaiswal AK; ''Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance.''; Free Radic Biol Med, 2013 PubMed Europe PMC Scholia
  12. Vijay R Baichwal, Patrick A Baeuerle; ''Apoptosis: Activate NF-κB or die?''; Current Biology, 1997
  13. Zhang J, Johnston G, Stebler B, Keller ET; ''Hydrogen peroxide activates NFkappaB and the interleukin-6 promoter through NFkappaB-inducing kinase.''; Antioxid Redox Signal, 2001 PubMed Europe PMC Scholia
  14. Xin M, Deng X; ''Nicotine inactivation of the proapoptotic function of Bax through phosphorylation.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  15. Howells CC, Baumann WT, Samuels DC, Finkielstein CV; ''The Bcl-2-associated death promoter (BAD) lowers the threshold at which the Bcl-2-interacting domain death agonist (BID) triggers mitochondria disintegration.''; J Theor Biol, 2011 PubMed Europe PMC Scholia
  16. Qi XJ, Wildey GM, Howe PH; ''Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  17. Nguyen Ho-Bouldoires TH, Clapéron A, Mergey M, Wendum D, Desbois-Mouthon C, Tahraoui S, Fartoux L, Chettouh H, Merabtene F, Scatton O, Gaestel M, Praz F, Housset C, Fouassier L; ''Mitogen-activated protein kinase-activated protein kinase 2 mediates resistance to hydrogen peroxide-induced oxidative stress in human hepatobiliary cancer cells.''; Free Radic Biol Med, 2015 PubMed Europe PMC Scholia
  18. Niture SK, Jaiswal AK; ''Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis.''; J Biol Chem, 2012 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
139486view16:06, 19 June 2025Anaïs Van MarsenilleOntology Term : 'malignant cell' added !
139485view16:06, 19 June 2025Anaïs Van MarsenilleOntology Term : 'cancer' added !
139484view16:06, 19 June 2025Anaïs Van MarsenilleOntology Term : 'cancer pathway' added !
138912view10:55, 7 May 2025Anaïs Van MarsenilleModified title
138909view10:48, 7 May 2025Anaïs Van MarsenilleModified title
138908view10:47, 7 May 2025Anaïs Van MarsenilleNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
ApoptosisPathway
BADGeneProduct572 (Entrez Gene)
BAXGeneProductENSG00000087088 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BimELProteinCHEBI:33173 (ChEBI)
Caspase 3GeneProductENSG00000164305 (Ensembl)
Caspase 7GeneProductENSG00000165806 (Ensembl)
Cytochrome CGeneProductENSG00000172115 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
HBEGFGeneProductENSG00000113070 (Ensembl)
Hsp27GeneProductENSG00000106211 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
MK2GeneProductENSG00000162889 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NRF2GeneProductENSG00000116044 (Ensembl)
PDK1GeneProductENSG00000152256 (Ensembl)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PTENGeneProduct5728 (Entrez Gene)
ROS (ex H2O2, nicotine)Metabolite

Annotated Interactions

No annotated interactions

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