Transcription activation (RNA-polymerase I and KAT2A/B) and inhibition (NuRD complex) (Homo sapiens)

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Description

This pathway describes the transcription activation (RNA-polymerase I and KAT2A/B) and inhibition (NuRD complex)in general. These processes are involved in the Tessadori-Bicknell-van Haaften syndrome 3 (TEBINVAD) - for an overview of this syndrome see WP5575.

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History

View all...
CompareRevisionActionTimeUserComment
140347view08:09, 13 August 2025Egonw1. Added a missing type, 2. fixed a data source
140342view19:30, 11 August 2025EgonwModified description
140317view09:57, 11 August 2025Fehrhartgraphical update
140316view09:52, 11 August 2025FehrhartOntology Term : 'epilepsy' added !
140315view09:52, 11 August 2025FehrhartOntology Term : 'transcription pathway' added !
140314view09:51, 11 August 2025FehrhartOntology Term : 'disease pathway' added !
140313view09:51, 11 August 2025FehrhartModified description
139717view11:25, 1 July 2025JmlohmannUpdated identifiers
139631view10:55, 24 June 2025JmlohmannAdjusted legend and added DNA identifier
139504view07:40, 20 June 2025JmlohmannAdjusted lay-out and removed irrelevant histone acetyltransferases
139454view10:39, 18 June 2025JmlohmannAdded legend.
139382view14:49, 11 June 2025JmlohmannNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASF1AGeneProductENSG00000111875 (Ensembl)
ASF1BGeneProductENSG00000105011 (Ensembl)
CDK2AP1GeneProductENSG00000111328 (Ensembl)
CHD3GeneProductENSG00000170004 (Ensembl)
CHD4GeneProductENSG00000111642 (Ensembl)
CREBBPGeneProductENSG00000005339 (Ensembl)
Chromatin assemblyPathwayR-HSA-774815 (Reactome)
Chromosome remodelingPathway
CycloheximideMetabolite6197 (PubChem-compound)
DNA4705 (ChEBI)
EP300GeneProductENSG00000100393 (Ensembl)
EP400GeneProductENSG00000183495 (Ensembl)
GATAD2AGeneProductENSG00000167491 (Ensembl)
GATAD2BGeneProductENSG00000143614 (Ensembl)
H2A.Z.2.2 (H2AZ2 variant)GeneProduct
H2AB1GeneProductENSG00000274183 (Ensembl)
H2AProteinB2R5B3 (Uniprot-TrEMBL)
H2AC14GeneProductENSG00000276368 (Ensembl)
H2AC18GeneProductENSG00000288825 (Ensembl)
H2AC20GeneProductENSG00000184260 (Ensembl)
H2AC6GeneProductENSG00000180573 (Ensembl)
H2AC7GeneProductENSG00000196866 (Ensembl)
H2AC8GeneProductENSG00000277075 (Ensembl)
H2AJGeneProductENSG00000246705 (Ensembl)
H2AXGeneProductENSG00000188486 (Ensembl)
H2AZ1GeneProductENSG00000164032 (Ensembl)
H2AZ2GeneProductENSG00000105968 (Ensembl)
H2BProteinB4DR52 (Uniprot-TrEMBL)
H2BC11GeneProductENSG00000124635 (Ensembl)
H2BC12GeneProductENSG00000197903 (Ensembl)
H2BC12LGeneProductENSG00000234289 (Ensembl)
H2BC13GeneProductENSG00000185130 (Ensembl)
H2BC14GeneProductENSG00000273703 (Ensembl)
H2BC15GeneProductENSG00000233822 (Ensembl)
H2BC17GeneProductENSG00000274641 (Ensembl)
H2BC1GeneProductENSG00000146047 (Ensembl)
H2BC21GeneProductENSG00000184678 (Ensembl)
H2BC26GeneProductENSG00000196890 (Ensembl)
H2BC3GeneProductENSG00000276410 (Ensembl)
H2BC4GeneProductENSG00000180596 (Ensembl)
H2BC5GeneProductENSG00000158373 (Ensembl)
H2BC9GeneProductENSG00000275713 (Ensembl)
H3-3BGeneProductENSG00000132475 (Entrez Gene)
H3ProteinB4E380 (Uniprot-TrEMBL)
H3C12GeneProductENSG00000197153 (Ensembl)
H3C13GeneProductENSG00000183598 (Ensembl)
H4 lysine 91ProteinP62805 (Uniprot-SwissProt)
H4C11GeneProductENSG00000197238 (Ensembl)
H4C12GeneProductENSG00000273542 (Ensembl)
H4C13GeneProductENSG00000275126 (Ensembl)
H4C14GeneProductENSG00000270882 (Ensembl)
H4C15GeneProductENSG00000270276 (Ensembl)
H4C16GeneProductENSG00000197837 (Ensembl)
H4C1GeneProductENSG00000278637 (Ensembl)
H4C2GeneProductENSG00000278705 (Ensembl)
H4C3GeneProductENSG00000197061 (Ensembl)
H4C4GeneProductENSG00000277157 (Ensembl)
H4C5GeneProductENSG00000276966 (Ensembl)
H4C6GeneProductENSG00000274618 (Ensembl)
H4C8GeneProductENSG00000158406 (Ensembl)
H4C9GeneProductENSG00000276180 (Ensembl)
H4ProteinP62805 (Uniprot-SwissProt)
HAT1GeneProductENSG00000128708 (Ensembl)
HDAC1GeneProductENSG00000116478 (Ensembl)
HDAC2GeneProductENSG00000196591 (Ensembl)
Histone H2AGeneProduct
Histone H2BGeneProduct
Histone H3GeneProduct
Histone H4GeneProduct
Histone acetylationPathwayR-HSA-3214847 (Reactome)
KAT2AGeneProductENSG00000108773 (Ensembl)
KAT2BGeneProductENSG00000114166 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MBD2GeneProductENSG00000134046 (Ensembl)
MBD3GeneProductENSG00000071655 (Ensembl)
MTA1GeneProductENSG00000182979 (Ensembl)
MTA2GeneProductENSG00000149480 (Ensembl)
POLR1AGeneProductENSG00000068654 (Ensembl)
POLR1BGeneProductENSG00000125630 (Ensembl)
POLR1CGeneProductENSG00000171453 (Ensembl)
POLR1DGeneProductENSG00000186184 (Ensembl)
PWWP2AGeneProductENSG00000170234 (Ensembl)
PWWP2BGeneProductENSG00000171813 (Ensembl)
RBBP4GeneProductENSG00000162521 (Ensembl)
RRN3GeneProductENSG00000085721 (Ensembl)
Rapid chromatin exchangesPathway
SIRT7GeneProductENSG00000187531 (Ensembl)
SL1-ComplexIPR052669 (EMBL)
SRCAPGeneProductENSG00000080603 (Ensembl)
TAF12GeneProductENSG00000120656 (Ensembl)
TAF1AGeneProductENSG00000143498 (Ensembl)
TAF1BGeneProductTAF1B (HGNC)
TAF1CGeneProductENSG00000103168 (Ensembl)
TAF1DGeneProductENSG00000166012 (Ensembl)
TBPGeneProductENSG00000112592 (Ensembl)
TLK2GeneProductENSG00000146872 (Ensembl)
Transcription activationPathwayR-HSA-73864 (Reactome)
UBTFGeneProductENSG00000108312 (Ensembl)
rDNA promoterProtein

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5565"