RNA-polymerase II transcription: the preinitiation complex (Homo sapiens)

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Description

This pathway shows the molecular details about the RNA Polymerase II transcription: the preinitiation complex. These processes are involved in the Tessadori-Bicknell-van Haaften syndrome 3 (TEBINVAD) - for an overview of this syndrome see WP5575.

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Quality Tags

Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
140339view19:29, 11 August 2025EgonwModified description
140328view10:54, 11 August 2025Fehrhartgraphical corrections
140327view10:48, 11 August 2025FehrhartModified description
140196view08:32, 6 August 2025DuanChanged the ELK1 binding to the mediator 23 only based on the literature review.
139711view10:24, 1 July 2025Jmlohmannadded pathway reference and legend TFIID complex
139627view10:05, 24 June 2025Jmlohmannensured RNA-polymerase II was written the same everywhere.
139509view09:43, 20 June 2025JmlohmannAdded reference
139465view03:39, 19 June 2025EgonwModified description
139450view09:33, 18 June 2025JmlohmannAdded legend
139445view14:49, 17 June 2025KhanspersOntology Term : 'regulatory pathway' added !
139444view14:49, 17 June 2025KhanspersOntology Term : 'RNA polymerase II transcription pathway' added !
139443view14:47, 17 June 2025KhanspersOntology Term : 'PW:0002656' removed !
139442view14:47, 17 June 2025KhanspersOntology Term : 'DNA biosynthetic pathway' added !
139439view10:11, 17 June 2025Jmlohmannadded genes for RNA polymerase 2 complex and CDK-8 interaction
139404view09:54, 15 June 2025EgonwMade a pathway clickable
139403view09:53, 15 June 2025EgonwType a gene as GeneProduct
139351view19:24, 3 June 2025JmlohmannAdded transcription initation pathway + Wikipathway identifier
139350view19:16, 3 June 2025Jmlohmannchanged 2 into II
139349view19:15, 3 June 2025JmlohmannNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
C-terminus RNA-polymerase IIComplex
CCNCGeneProductENSG00000112237 (Ensembl)
CDK8GeneProductENSG00000132964 (Ensembl)
CTDP1GeneProductENSG00000060069 (Ensembl)
ELK1GeneProductENSG00000126767 (Ensembl)
ERCC3GeneProductENSG00000163161 (Ensembl)
Epilepsy or seizure causing genes
Eukaryotic transcription initiationPathwayWP405 (WikiPathways)
GTF2A1GeneProductENSG00000165417 (Ensembl)
GTF2BGeneProductENSG00000137947 (Ensembl)
GTF2E2GeneProductENSG00000197265 (Ensembl)
GTF2F1GeneProductENSG00000125651 (Ensembl)
MED10GeneProductENSG00000133398 (Ensembl)
MED11GeneProductENSG00000161920 (Ensembl)
MED12GeneProductENSG00000184634 (Ensembl)
MED13GeneProductENSG00000108510 (Ensembl)
MED14GeneProductENSG00000180182 (Ensembl)
MED15GeneProductENSG00000099917 (Ensembl)
MED16GeneProductENSG00000175221 (Ensembl)
MED17GeneProductENSG00000042429 (Ensembl)
MED18GeneProductENSG00000130772 (Ensembl)
MED19GeneProductENSG00000156603 (Ensembl)
MED1GeneProductENSG00000125686 (Ensembl)
MED20GeneProductENSG00000124641 (Ensembl)
MED21GeneProductENSG00000152944 (Ensembl)
MED22GeneProductENSG00000148297 (Ensembl)
MED23GeneProductENSG00000112282 (Ensembl)
MED24GeneProductENSG00000008838 (Ensembl)
MED25GeneProductENSG00000104973 (Ensembl)
MED26GeneProductENSG00000105085 (Ensembl)
MED27GeneProductENSG00000160563 (Ensembl)
MED28GeneProductENSG00000118579 (Ensembl)
MED29GeneProductENSG00000063322 (Ensembl)
MED30GeneProductENSG00000164758 (Ensembl)
MED31GeneProductENSG00000108590 (Ensembl)
MED4GeneProductENSG00000136146 (Ensembl)
MED6GeneProductENSG00000133997 (Ensembl)
MED7GeneProductENSG00000155868 (Ensembl)
MED8GeneProductENSG00000159479 (Ensembl)
MED9GeneProductENSG00000141026 (Ensembl)
Mediator 26-subunit
NELFAGeneProductENSG00000185049 (Ensembl)
NELFBGeneProductENSG00000188986 (Ensembl)
NELFCDGeneProductENSG00000101158 (Ensembl)
NELFEGeneProductENSG00000204356 (Ensembl)
POLR2AGeneProductENSG00000181222 (Ensembl)
POLR2BGeneProductENSG00000047315 (Ensembl)
POLR2CGeneProductENSG00000102978 (Ensembl)
POLR2DGeneProductENSG00000144231 (Ensembl)
POLR2EGeneProductPOLR2E (HGNC)
POLR2FGeneProductENSG00000100142 (Ensembl)
POLR2GGeneProductENSG00000168002 (Ensembl)
POLR2HProteinC9JJJ9 (Uniprot-TrEMBL)
POLR2IGeneProductENSG00000105258 (Ensembl)
POLR2JGeneProductENSG00000005075 (Ensembl)
POLR2KGeneProductENSG00000147669 (Ensembl)
POLR2LGeneProductENSG00000177700 (Ensembl)
POLR2MGeneProductENSG00000255529 (Ensembl)
Promoter escapePathway
Promoter openingPathway
RNA-polymerase IIComplex
RNA-polymerase II Transcription ElongationPathwayR-HSA-75955 (Reactome)
TAF 13-subunit
TAF10GeneProductENSG00000166337 (Ensembl)
TAF11GeneProductENSG00000064995 (Ensembl)
TAF12GeneProductENSG00000120656 (Ensembl)
TAF13GeneProductENSG00000197780 (Ensembl)
TAF1GeneProductENSG00000147133 (Ensembl)
TAF2GeneProductENSG00000064313 (Ensembl)
TAF3GeneProductENSG00000165632 (Ensembl)
TAF4GeneProductENSG00000130699 (Ensembl)
TAF5GeneProductENSG00000148835 (Ensembl)
TAF6GeneProductENSG00000106290 (Ensembl)
TAF7GeneProductENSG00000178913 (Ensembl)
TAF8GeneProductENSG00000137413 (Ensembl)
TAF9GeneProductENSG00000273841 (Ensembl)
TBPGeneProductENSG00000112592 (Ensembl)
TFIID ComplexComplex
THRAGeneProductENSG00000126351 (Ensembl)
Transcription factor
Transcription factors (TF)
Transcriptional activationPathway

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5563"