Human Fact complex and DNA double-strand break (repair) (Homo sapiens)

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Description

This pathway shows the molecular details on the human Fact complex and DNA double-strand break (repair). These processes are involved in the Tessadori-Bicknell-van Haaften syndrome 3 (TEBINVAD) - for an overview of this syndrome see [WP5575](http://wikipathways.org/instance/WP5575).

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Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
140337view19:27, 11 August 2025EgonwModified description
140333view10:59, 11 August 2025Fehrhartsmall graphical corrections
140332view10:56, 11 August 2025FehrhartOntology Term : 'epilepsy' added !
140331view10:56, 11 August 2025FehrhartOntology Term : 'DNA repair pathway' added !
140330view10:56, 11 August 2025FehrhartOntology Term : 'disease pathway' added !
140329view10:56, 11 August 2025FehrhartModified description
140199view09:47, 6 August 2025DuanUpdated the RNF8 and NBN recruitment mechanism.
139777view15:57, 4 July 2025Jmlohmannadjusted the writing of dna double-strand break
139716view11:12, 1 July 2025Jmlohmannadded identifiers
139630view10:29, 24 June 2025JmlohmannAdjusted RNA-polymerase and added DNA identifier
139451view10:07, 18 June 2025JmlohmannAdded legend.
139381view08:19, 11 June 2025JmlohmannAdd protein identifiers of histones
139355view13:42, 5 June 2025JmlohmannNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATMGeneProductENSG00000149311 (Ensembl)
DNA double-strand break repair PathwayWP438 (WikiPathways)
DNA double-strand breaks (DSB)Metabolite61120 (ChEBI)
DNAMetabolite4705 (ChEBI)
H1ProteinQ02539 (Uniprot-TrEMBL)
H2A variantProtein
H2AProteinB2R5B3 (Uniprot-TrEMBL)
H2BProteinB4DR52 (Uniprot-TrEMBL)
H3ProteinB4E380 (Uniprot-TrEMBL)
H4ProteinP62805 (Uniprot-TrEMBL)
MDC1GeneProductENSG00000137337 (Ensembl)
NAP1L1GeneProductENSG00000187109 (Ensembl)
NASPGeneProductENSG00000132780 (Ensembl)
NBNGeneProductENSG00000104320 (Ensembl)
PRKDCGeneProductENSG00000253729 (Ensembl)
RAD51GeneProductENSG00000051180 (Ensembl)
RAD54LGeneProductENSG00000085999 (Ensembl)
RNA-polymerase IIComplexR-HSA-6814541 (Reactome)
RNF168GeneProductENSG00000163961 (Ensembl)
RNF8GeneProductENSG00000112130 (Ensembl)
SETD2GeneProductENSG00000181555 (Ensembl)
SSRP1GeneProductENSG00000149136 (Ensembl)
SUPT16HGeneProductENSG00000092201 (Ensembl)
TP53BP1GeneProductENSG00000067369 (Ensembl)
Ubiquitination of H2APathwayR-HSA-597592 (Reactome)
XRCC5GeneProductENSG00000079246 (Ensembl)
XRCC6GeneProductENSG00000196419 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5564"