Parthanatos cell death signaling pathway (Homo sapiens)

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Description

This is pathway is an illustration for pathanatos. Parthanatos is a cell death signaling pathway in which excessive oxidative damage to DNA leads to over-activation of poly(ADP-ribose) polymerase (PARP). PARP then generates the formation of large poly(ADP-ribose) polymers that induce the release of apoptosis-inducing factor from the outer mitochondrial membrane.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. ''''; , PubMed Europe PMC Scholia
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  7. Wang Y, Kim NS, Haince JF, Kang HC, David KK, Andrabi SA, Poirier GG, Dawson VL, Dawson TM; ''Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos).''; Sci Signal, 2011 PubMed Europe PMC Scholia
  8. ''''; , PubMed Europe PMC Scholia
  9. ''''; , PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
140450view14:56, 25 August 2025KhanspersModified title
140396view11:08, 17 August 2025EgonwMade a pathway clickable
140386view20:06, 15 August 2025AlexanderPicoModified title
140385view20:06, 15 August 2025AlexanderPicoOntology Term : 'regulatory pathway' added !
140384view20:06, 15 August 2025AlexanderPicoOntology Term : 'cell death pathway' added !
140383view20:04, 15 August 2025AlexanderPicolit refs
140382view20:02, 15 August 2025AlexanderPicofixing lit refs
140094view11:25, 25 July 2025DuanNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADP-ribosesMetaboliteCHEBI:16960 (ChEBI)
AIFM1GeneProductENSG00000156709 (Ensembl)
Cell death Pathway
DNA damagePathwayWP1530 (WikiPathways)
Double-stranded DNAMetaboliteCHEBI:4705 (ChEBI)
MIFGeneProduct4282 (Entrez Gene)
NOMetaboliteCHEBI:16480 (ChEBI)
Nicotinamide adenine dinucleotide(NAD+)MetaboliteCHEBI:15846 (ChEBI)
ONOO-MetaboliteCHEBI:25941 (ChEBI)
PAR polymers
PARP1GeneProductENSG00000143799 (Ensembl)
ROS MetaboliteCHEBI:70982 (ChEBI)
superoxide anion radicalMetaboliteCHEBI:18421 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5585"