Deregulating cellular metabolism through non-genotoxic carcinogens (Homo sapiens)

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Description

Pathway representing the non-genotoxic induction, through doxycycline and FCCP, of the hallmark of cancer deregulating cellular metabolism. This pathway mainly focuses on the role of the mitochondria and it's dysregulation.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Quirós PM, Prado MA, Zamboni N, D'Amico D, Williams RW, Finley D, Gygi SP, Auwerx J; ''Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.''; J Cell Biol, 2017 PubMed Europe PMC Scholia
  2. Magnuson B, Ekim B, Fingar DC; ''Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks.''; Biochem J, 2012 PubMed Europe PMC Scholia
  3. Shin J, Bae J, Park S, Kang HG, Shin SM, Won G, Kim JS, Cho SG, Choi Y, Oh SM, Park HW; ''mTOR-Dependent Role of Sestrin2 in Regulating Tumor Progression of Human Endometrial Cancer.''; Cancers (Basel), 2020 PubMed Europe PMC Scholia
  4. ''The Akt pathway in oncology therapy and beyond (Review)''; Int J Oncol., 2018 PubMed Europe PMC Scholia
  5. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM; ''Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.''; Science, 2005 PubMed Europe PMC Scholia
  6. Saxton RA, Knockenhauer KE, Wolfson RL, Chantranupong L, Pacold ME, Wang T, Schwartz TU, Sabatini DM; ''Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.''; Science, 2016 PubMed Europe PMC Scholia
  7. Kowalsky AH, Namkoong S, Mettetal E, Park HW, Kazyken D, Fingar DC, Lee JH; ''The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation.''; J Biol Chem, 2020 PubMed Europe PMC Scholia
  8. Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM; ''Sestrin2 is a leucine sensor for the mTORC1 pathway.''; Science, 2016 PubMed Europe PMC Scholia
  9. Matts RL, Levin DH, London IM; ''Effect of phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 on the function of reversing factor in the initiation of protein synthesis.''; Proc Natl Acad Sci U S A, 1983 PubMed Europe PMC Scholia
  10. ''''; , PubMed Europe PMC Scholia
  11. Sarcinelli C, Dragic H, Piecyk M, Barbet V, Duret C, Barthelaix A, Ferraro-Peyret C, Fauvre J, Renno T, Chaveroux C, Manié SN; ''ATF4-Dependent NRF2 Transcriptional Regulation Promotes Antioxidant Protection during EndoplasmicReticulum Stress.''; Cancers (Basel), 2020 PubMed Europe PMC Scholia
  12. Kenta Masui, Kazuhiro Tanaka, David Akhavan, Ivan Babic, Beatrice Gin, Tomoo Matsutani, Akio Iwanami, Feng Liu, Genaro R. Villa, Yuchao Gu, Carl Campos, Shaojun Zhu, Huijun Yang, William H. Yong, Timothy F. Cloughesy, Ingo K. Mellinghoff, Webster K. Cavenee, Reuben J. Shaw, Paul S. Mischel; ''mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-cccxMyc''; Cell Metabolism, 2013 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
140572view07:54, 14 September 2025EgonwFixed two references
140394view11:05, 17 August 2025EgonwFixed two datasources
140393view11:04, 17 August 2025EgonwRemoved template comments
140367view18:18, 15 August 2025AlexanderPicoModified title
139480view16:04, 19 June 2025Anaïs Van MarsenilleOntology Term : 'malignant cell' added !
139479view13:59, 19 June 2025Anaïs Van MarsenilleOntology Term : 'cancer' added !
139478view13:54, 19 June 2025Anaïs Van MarsenilleOntology Term : 'cancer pathway' added !
139418view15:53, 16 June 2025Anaïs Van MarsenilleModified title
139417view15:51, 16 June 2025Anaïs Van MarsenilleNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AMPKProtein2.7.11.1 (Enzyme Nomenclature)
ATF4GeneProductENSG00000128272 (Ensembl)
CLPPGeneProductENSG00000125656 (Ensembl)
Class IIa HDACsProtein3.5.1.98 (Enzyme Nomenclature)
DoxycyclineMetaboliteHMDB14399 (HMDB)
EIF2AGeneProductENSG00000144895 (Ensembl)
FCCPMetaboliteCHEBI:75458 (ChEBI)
FOXO1GeneProductENSG00000150907 (Ensembl)
GATOR2Complex
GDF15GeneProductENSG00000130513 (Ensembl)
HSPD1GeneProductENSG00000144381 (Ensembl)
IRS1GeneProductENSG00000169047 (Ensembl)
ISRPathway
KEGGGeneProduct
LARS1GeneProductENSG00000133706 (Ensembl)
LAT1GeneProductENSG00000155465 (Ensembl)
LONP1GeneProductENSG00000196365 (Ensembl)
LONP2GeneProductENSG00000102910 (Ensembl)
MARS1GeneProductENSG00000166986 (Ensembl)
MSRPathway
MTORC1GeneProductENSG00000198793 (Ensembl)
MYC TargetsGeneProduct
MYCGeneProductENSG00000136997 (Ensembl)
OMA1GeneProductENSG00000162600 (Ensembl)
PHB1GeneProductENSG00000167085 (Ensembl)
PHB2GeneProductENSG00000215021 (Ensembl)
PI3KProteinIPR000403 (InterPro)
Protein secretionProtein
S6K1GeneProduct
SESN2GeneProductENSG00000130766 (Ensembl)
TRAP1GeneProductENSG00000126602 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
leucineMetaboliteCHEBI:25017 (ChEBI)
mTORC2GeneProductENSG00000198793 (Ensembl)
mtDNAGeneProduct
mtUPRGeneProduct
oxPHOSGeneProduct

Annotated Interactions

No annotated interactions

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