PDGF pathway (Bos taurus)

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Description

PDGF belongs to the PDGF/VEGF (vascular endothelial growth factor) family, which is characterized by eight strictly conserved cysteine residues with similar spacing in between (Joukov et al., 1997; Heldin and Westermark, 1999). The A-, B-, C-, and D-chain genes of PDGF are localized to the chromosomes 7p22, 22q13, 4q31, and 11q22, respectively, and their expression is independently regulated. Two forms of the PDGF A-chain, containing 196 and 211 amino acid residues resulting from differential splicing of the transcript, are synthesized, dimerized, proteolytically processed in the Nterminus, and secreted from the cell as a ~30 kDa dimer. The PDGF B chain encoding 241 amino acid residues is dimerized, processed by additional proteolysis, and secreted as a 24 kDa dimer. The homodimers PDGF AA, BB, and the heterodimer AB contain three intrachain disulfide bonds.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP2526_96312 with a 90.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Heldin CH, Hammacher A, Nistأ©r M, Westermark B; ''Structural and functional aspects of platelet-derived growth factor.''; Br J Cancer, 1988 PubMed Europe PMC Scholia
  2. Hannink M, Donoghue DJ; ''Structure and function of platelet-derived growth factor (PDGF) and related proteins.''; Biochim Biophys Acta, 1989 PubMed Europe PMC Scholia
  3. Claesson-Welsh L, Heldin CH; ''Platelet-derived growth factor. Three isoforms that bind to two distinct cell surface receptors.''; Acta Oncol, 1989 PubMed Europe PMC Scholia
  4. Farooqi AA, Waseem S, Riaz AM, Dilawar BA, Mukhtar S, Minhaj S, Waseem MS, Daniel S, Malik BA, Nawaz A, Bhatti S; ''PDGF: the nuts and bolts of signalling toolbox.''; Tumour Biol, 2011 PubMed Europe PMC Scholia
  5. Heldin CH; ''Autocrine PDGF stimulation in malignancies.''; Ups J Med Sci, 2012 PubMed Europe PMC Scholia
  6. Heldin CH, Westermark B; ''Platelet-derived growth factors: a family of isoforms that bind to two distinct receptors.''; Br Med Bull, 1989 PubMed Europe PMC Scholia
  7. Antoniades HN; ''PDGF: a multifunctional growth factor.''; Baillieres Clin Endocrinol Metab, 1991 PubMed Europe PMC Scholia
  8. Kawahara RS, Deng ZW, Deuel TF; ''PDGF and the small inducible gene (SIG) family: roles in the inflammatory response.''; Adv Exp Med Biol, 1991 PubMed Europe PMC Scholia
  9. Andrae J, Gallini R, Betsholtz C; ''Role of platelet-derived growth factors in physiology and medicine.''; Genes Dev, 2008 PubMed Europe PMC Scholia
  10. Smith CL, Tallquist MD; ''PDGF function in diverse neural crest cell populations.''; Cell Adh Migr, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
140651view06:18, 28 September 2025EgonwH⁺ with unicode
140650view06:18, 28 September 2025EgonwRemoved unfinished part of the sentence
140012view05:49, 18 July 2025EgonwCalcium ion with unicode
117588view11:24, 21 May 2021EweitzModified title
115747view11:16, 9 March 2021EgonwReplaced the WP id of a human pathways with the matching cow pathway
107066view14:15, 17 September 2019MaintBotChEBI identifier normalization
105947view11:47, 16 August 2019MaintBotHMDB identifier normalization
101990view18:36, 22 November 2018EgonwRemoved whitespace in PubMed identifiers.
96313view09:03, 8 March 2018MkutmonUpdated homology conversion
92373view16:19, 30 May 2017DdiglesOntology Term : 'platelet-derived growth factor signaling pathway' added !
92319view09:32, 22 May 2017RyanmillerOntology Term : 'Jak-Stat signaling pathway' added !
92219view15:31, 11 May 2017EgonwRemoved incorrect CAS annotations (10043-52-4 is CaCl2)
80787view15:26, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment

Ca

c h a n n e

l		Protein

Na+/H+

e x c h a n g e

r		Protein
ARFIP2ProteinENSBTAG00000003566 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P53365
Actin,

Stress Fibers

and Adhesion		PathwayWP3197 (WikiPathways)
Akt PathwayPathway
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
CDC42ProteinNo homologues found for original id S:P60953
CHUKProteinENSBTAG00000007591 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:O15111
Ca²⁺MetaboliteCHEBI:29108 (ChEBI)
Cell MigrationPathway
Cell proliferationPathway
Cyclic AMP (cAMP)MetaboliteHMDB0000058 (HMDB)
DAGMetaboliteLMGL02010000 (LIPID MAPS)
DegradationPathway
ELK1GeneProductENSBTAG00000015817 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P19419
FOSGeneProductENSBTAG00000004322 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P01100
Filopodia FormationPathway
GRB2ProteinENSBTAG00000004736 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P62993
HRASGeneProductENSBTAG00000046644 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3265
H⁺MetaboliteCHEBI:15378 (ChEBI)
IP3MetaboliteCHEBI:16595 (ChEBI)
JAK1ProteinENSBTAG00000003147 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P23458
JUNGeneProductENSBTAG00000004037 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P05412
Lamellipodia FormationPathway
MAP2K1GeneProductENSBTAG00000033983 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:Q02750
MAP2K4GeneProductENSBTAG00000012103 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6416
MAP3K1GeneProductENSBTAG00000013790 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:Q13233
MAPK1GeneProductENSBTAG00000010312 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5594
MAPK3GeneProductENSBTAG00000016156 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5595
MAPK8GeneProductENSBTAG00000007876 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P45983
MT-CO2ProteinENSBTAG00000043556 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P00403
NFKBIAGeneProductENSBTAG00000016683 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P25963
NFkBGeneProduct
NaMetaboliteCHEBI:29101 (ChEBI)
PAK1ProteinENSBTAG00000010191 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:Q13153
PDGFAGeneProductENSBTAG00000014541 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5154
PDGFBGeneProductENSBTAG00000021697 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5155
PDGFRBGeneProductENSBTAG00000002804 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000113721
PIK3R1ProteinENSBTAG00000010989 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P27986
PIP2[4',5']MetaboliteLMGP08010003 (LIPID MAPS)
PLA2G4AGeneProductENSBTAG00000013298 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000116711
PLCG1GeneProductENSBTAG00000017584 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000124181
PTPN11GeneProductENSBTAG00000002048 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:Q06124
Phospholipid (containing arachidonic acid)MetaboliteCHEBI:16247 (ChEBI)
Prostaglandin I2 (PGI2)MetaboliteHMDB0001335 (HMDB)
RAC1ProteinENSBTAG00000009233 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P63000
RAF1ProteinENSBTAG00000004514 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P04049
RASA1GeneProductENSBTAG00000009565 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000145715
RHOAProteinENSBTAG00000004279 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P61586
SHC1ProteinENSBTAG00000019838 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P29353
SOS1ProteinENSBTAG00000011643 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:Q07889
SRCProteinENSBTAG00000008938 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P12931
SRFGeneProductENSBTAG00000012777 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P11831
STAT1ProteinENSBTAG00000007867 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P42224
STAT3ProteinENSBTAG00000021523 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P40763
TIAM1ProteinENSBTAG00000017839 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:Q13009
VAV1ProteinENSBTAG00000039160 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P15498
VAV2ProteinENSBTAG00000004511 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P52735
WASLProteinENSBTAG00000004643 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:O00401
[Ca²⁺]iMetaboliteCHEBI:29108 (ChEBI)

Annotated Interactions

No annotated interactions
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