Nicotine biosynthesis (Nicotiana tabacum)

From WikiPathways

Revision as of 12:43, 29 November 2025 by Egonw (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search


Description

This pathway describes the biosynthesis of nicotine in tobacco (Nicotiana tabacum). Nicotine is composed of a pyrrolidine and a pyridine ring, which are formed from amino acid precursors early in the pathway and are condensed in later steps.

[Genetic regulation and manipulation of nicotine biosynthesis in tobacco: strategies to eliminate addictive alkaloids](https://pmc.ncbi.nlm.nih.gov/articles/PMC10938045/)

[Clustered Transcription Factor Genes Regulate Nicotine Biosynthesis in Tobacco](https://pmc.ncbi.nlm.nih.gov/articles/PMC2990138/)

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Shoji T, Hashimoto T, Saito K; ''Genetic regulation and manipulation of nicotine biosynthesis in tobacco: strategies to eliminate addictive alkaloids.''; J Exp Bot, 2024 PubMed Europe PMC Scholia
  2. ''Clustered transcription factor genes regulate nicotine biosynthesis in tobacco''; Plant Cell, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
141987view12:43, 29 November 2025EgonwAdded missing article info
141928view07:44, 27 November 2025HayashiModified description
141927view07:40, 27 November 2025HayashiOntology Term : 'pyridine nucleotide biosynthetic pathway' added !
141926view07:34, 27 November 2025HayashiOntology Term : 'metabolic pathway of secondary metabolites' added !
141920view07:14, 27 November 2025HayashiAnnotated data nodes with database identifiers
140624view11:58, 21 September 2025MaintBotAnother update
140623view11:57, 21 September 2025MaintBotUpdated title and description
140622view11:57, 21 September 2025MaintBotNicotiana tabacum is now supported
140615view06:34, 18 September 2025HayashiNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
A622GeneProduct107784748 (Entrez Gene)
AO1GeneProduct107787119 (Entrez Gene)
AO2GeneProduct107779537 (Entrez Gene)
BBLGeneProduct107779537 (Entrez Gene)
CYP82EGeneProduct107819427 (Entrez Gene)
JAMetaboliteCHEBI:18292 (ChEBI)
MPOGeneProduct107807126 (Entrez Gene)
N-methylputrescineMetaboliteCHEBI:17166 (ChEBI)
N-methylpyrrolinium cationMetaboliteCHEBI:58039 (ChEBI)
NADMetaboliteHMDB00902 (HMDB)
ODC1GeneProduct107801491 (Entrez Gene)
ODC2GeneProduct107815922 (Entrez Gene)
PMTGeneProduct107799425 (Entrez Gene)
QPT1GeneProduct107829123 (Entrez Gene)
QPT2GeneProduct107829122 (Entrez Gene)
QSGeneProduct107813484 (Entrez Gene)
aspartateMetaboliteCHEBI:29995 (ChEBI)
nicotineMetaboliteCHEBI:18723 (ChEBI)
nicotinic acid mononucleotideMetaboliteCHEBI:37008 (ChEBI)
nicotinic acidMetaboliteCHEBI:15940 (ChEBI)
nornicotineMetaboliteCHEBI:189656 (ChEBI)
ornithineMetaboliteCHEBI:18257 (ChEBI)
putrescineMetaboliteCHEBI:17148 (ChEBI)
quinolinateMetaboliteCHEBI:29959 (ChEBI)
α-iminosuccinateMetaboliteCHEBI:50616 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5595"
Personal tools