Integrated cancer pathway (Bos taurus)

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Revision as of 00:19, 5 December 2025 by Khanspers (Talk | contribs)
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Description

This integrated cancer pathway describes the key mechanisms involved in the development of cancer containing the key prognostic markers and pathogenetic factors.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP1971(80447) with a 81.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Zhao JJ, Lin J, Lwin T, Yang H, Guo J, Kong W, Dessureault S, Moscinski LC, Rezania D, Dalton WS, Sotomayor E, Tao J, Cheng JQ; ''microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma.''; Blood, 2010 PubMed Europe PMC Scholia
  2. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, Krichevsky AM; ''MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.''; Mol Cell Biol, 2008 PubMed Europe PMC Scholia
  3. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T; ''MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer.''; Gastroenterology, 2007 PubMed Europe PMC Scholia
  4. Wang C, Bian Z, Wei D, Zhang JG; ''miR-29b regulates migration of human breast cancer cells.''; Mol Cell Biochem, 2011 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
142134view00:19, 5 December 2025KhanspersModified description
117557view11:18, 21 May 2021EweitzModified title
80873view15:29, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1ProteinENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P31749
ATF1GeneProductENSBTAG00000018131 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123268
ATMProteinENSBTAG00000003111 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13315
ATRProteinENSBTAG00000011529 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13535
BACH1GeneProductENSBTAG00000004139 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000156273
BADProteinENSBTAG00000012511 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q92934
BARD1ProteinENSBTAG00000033690 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q99728
BAXProteinENSBTAG00000013340 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q07812
BCL2ProteinENSBTAG00000019302 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P10415
BLMProteinENSBTAG00000020301 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P54132
BRCA1ProteinENSBTAG00000022520 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P38398
CASP3ProteinENSBTAG00000015874 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P42574
CASP8ProteinENSBTAG00000015718 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q14790
CASP9ProteinENSBTAG00000002472 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P55211
CDC25AGeneProductENSBTAG00000009586 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164045
CDC25BGeneProductENSBTAG00000008436 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101224
CDK1ProteinENSBTAG00000010109 (Ensembl)
  • Oncogene
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P06493
CDK2ProteinENSBTAG00000004021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P24941
CDK4_HUMANProteinENSBTAG00000046091 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P11802
CDKN1AProteinENSBTAG00000008353 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026
CDKN1BProteinENSBTAG00000018254 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1027
CDKN2BProteinENSBTAG00000016412 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1030
CHEK1ProteinENSBTAG00000017582 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O14757
CHEK2ProteinENSBTAG00000004956 (Ensembl)
  • Phosphrylated
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O96017
CctlpProtein
DNA-PKMetabolite
E2F1ProteinENSBTAG00000003971 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q01094
JAK1ProteinENSBTAG00000003147 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P23458
MAP3K5ProteinENSBTAG00000009065 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4217
MDM2ProteinENSBTAG00000010422 (Ensembl)
  • Oncogene
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q00987
MIR29B1Rna
MIR29B2Rna
MIR29CRna
MMP1ProteinENSBTAG00000048029 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P03956
MRE11AProteinENSBTAG00000008925 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P49959
MSH2ProteinENSBTAG00000002742 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P43246
MSH6ProteinENSBTAG00000001424 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P52701
MYCGeneProductENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136997
NOXA1ProteinENSBTAG00000012121 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q86UR1
PLK1GeneProductENSBTAG00000014453 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166851
POU2F1ProteinENSBTAG00000024534 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5451
PTENProteinENSBTAG00000009498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P60484
PUMAProtein
Q8NBS1_HUMANProtein
RAD50ProteinENSBTAG00000011252 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q92878
RB1ProteinENSBTAG00000006640 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P06400
SMAD2ProteinENSBTAG00000039916 (Ensembl)
  • Tumor supressor
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q15796
SMAD3ProteinENSBTAG00000012599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P84022
STAT1ProteinENSBTAG00000007867 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P42224
Swi/SNFProtein
TP53ProteinENSBTAG00000001069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P04637
bta-mir-21RnaENSBTAG00000029897 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199004
p13KProtein
p14Protein
p38Protein

Annotated Interactions

No annotated interactions
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