Mitochondrial fatty acid synthesis pathway (Bombyx mori)
From WikiPathways
Description
Schematic presentation of the sequence of events. The indicated abbreviations follow the nomenclature used for the human enzymes and proteins. ACC, acetyl-CoA carboxylase; MCT, malonyl-CoA transferase; ACP, acyl-carrier protein; KAS, ketoacyl synthase; KAR, ketoacyl reductase; HTD2, hydroxyacyl-thioester reductase type 2; ETR, enoyl-thioester reductase. [J. Kastaniotis et al 2010]
The original pathway (https://www.wikipathways.org/pathways/WP4317) was lifted into Bombyx mori.
Quality Tags
Ontology Terms
Saving...Bibliography
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- Hiltunen JK, Schonauer MS, Autio KJ, Mittelmeier TM, Kastaniotis AJ, Dieckmann CL; ''Mitochondrial fatty acid synthesis type II: more than just fatty acids.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
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- Hiltunen JK, Autio KJ, Schonauer MS, Kursu VA, Dieckmann CL, Kastaniotis AJ; ''Mitochondrial fatty acid synthesis and respiration.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
- Krebs HA, Holzach O; ''The conversion of citrate into cis-aconitate and isocitrate in the presence of aconitase.''; Biochem J, 1952 PubMed Europe PMC Scholia
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- Lambeth DO, Tews KN, Adkins S, Frohlich D, Milavetz BI; ''Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
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- Sheu KF, Blass JP; ''The alpha-ketoglutarate dehydrogenase complex.''; Ann N Y Acad Sci, 1999 PubMed Europe PMC Scholia
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- Des Rosiers C, Di Donato L, Comte B, Laplante A, Marcoux C, David F, Fernandez CA, Brunengraber H; ''Isotopomer analysis of citric acid cycle and gluconeogenesis in rat liver. Reversibility of isocitrate dehydrogenase and involvement of ATP-citrate lyase in gluconeogenesis.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
- Sazanov LA, Jackson JB; ''Proton-translocating transhydrogenase and NAD- and NADP-linked isocitrate dehydrogenases operate in a substrate cycle which contributes to fine regulation of the tricarboxylic acid cycle activity in mitochondria.''; FEBS Lett, 1994 PubMed Europe PMC Scholia
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History
External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| 3-Hydroxyacyl-ACP | Metabolite | CHEBI:57318 (ChEBI)  | |
| 3-Ketoacyl-ACP | Metabolite | CHEBI:57347 (ChEBI) | |
| ACACA | GeneProduct | MSTRG.13138.1 (Other) | |
| ACACA | GeneProduct | MSTRG.13138.2 (Other) | |
| ACACA | GeneProduct | MSTRG.13138.3 (Other) | |
| ACACA | GeneProduct | MSTRG.13138.4 (Other) | |
| ACACA | GeneProduct | MSTRG.13138.5 (Other) | |
| ATP | Metabolite | HMDB0000538 (HMDB) | The ChEBI ID with the correct charge is: 30616 |
| Acetyl-CoA | Metabolite | HMDB0001206 (HMDB) | The ChEBI ID with the correct charge is: 57288 |
| Acetyl/Acyl-ACP | Metabolite | Q59811305 (Wikidata) | |
| Acyl-ACP | Metabolite | ||
| CO₂ | Metabolite | HMDB0001967 (HMDB) | |
| H | Metabolite | CHEBI:15378 (ChEBI) | |
| HSD17B12 | GeneProduct | KWMTBOMO09705 (Other) | |
| HTD2 | GeneProduct | MSTRG.6386.4 (Other) | |
| KAS | GeneProduct | KWMTBOMO05530 (Other) | |
| MCAT | GeneProduct | KWMTBOMO02353 (Other) | |
| MCAT | GeneProduct | MSTRG.18125.1 (Other) | |
| MCAT | GeneProduct | MSTRG.18125.2 (Other) | |
| MECR | GeneProduct | MSTRG.16754.11 (Other) | |
| MECR | GeneProduct | MSTRG.16754.12 (Other) | |
| MECR | GeneProduct | MSTRG.16754.13 (Other) | |
| MECR | GeneProduct | MSTRG.16754.1 (Other) | |
| MECR | GeneProduct | MSTRG.16754.2 (Other) | |
| MECR | GeneProduct | MSTRG.16754.5 (Other) | |
| MECR | GeneProduct | MSTRG.16754.7 (Other) | |
| MECR | GeneProduct | MSTRG.16754.9 (Other) | |
| Malonyl-ACP | Metabolite | C01209 (KEGG Compound) | |
| Malonyl-CoA | Metabolite | HMDB0001175 (HMDB) | |
| Medium/Long-chain fatty acids | Metabolite | ||
| NADPH | Metabolite | HMDB0000221 (HMDB) | The ChEBI ID with the correct charge is: 57783 |
| NADP | Metabolite | HMDB0000217 (HMDB) | |
| Octanoyl-ACP | Metabolite | CHEBI:7725 (ChEBI) | |
| Trans-2-enoyl-ACP | Metabolite | C05748 (KEGG Compound) | |
| water | Metabolite | HMDB0002111 (HMDB) |
Annotated Interactions
No annotated interactions
