Mitochondrial fatty acid synthesis pathway (Apis cerana)
From WikiPathways
Description
Schematic presentation of the sequence of events. The indicated abbreviations follow the nomenclature used for the human enzymes and proteins. ACC, acetyl-CoA carboxylase; MCT, malonyl-CoA transferase; ACP, acyl-carrier protein; KAS, ketoacyl synthase; KAR, ketoacyl reductase; HTD2, hydroxyacyl-thioester reductase type 2; ETR, enoyl-thioester reductase. [J. Kastaniotis et al 2010]
The original pathway (https://www.wikipathways.org/pathways/WP4317) was lifted into Apis cerana.
Quality Tags
Ontology Terms
Saving...Bibliography
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- Gabriel JL, Zervos PR, Plaut GW; ''Activity of purified NAD-specific isocitrate dehydrogenase at modulator and substrate concentrations approximating conditions in mitochondria.''; Metabolism, 1986 PubMed Europe PMC Scholia
- Hiltunen JK, Autio KJ, Schonauer MS, Kursu VA, Dieckmann CL, Kastaniotis AJ; ''Mitochondrial fatty acid synthesis and respiration.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
- Lawson AM, Chalmers RA, Watts RW; ''Urinary organic acids in man. I. Normal patterns.''; Clin Chem, 1976 PubMed Europe PMC Scholia
- Greksák M, Lopes-Cardozo M, van den Bergh SG; ''Citrate synthesis in intact rat-liver mitochondria is irreversible.''; Eur J Biochem, 1982 PubMed Europe PMC Scholia
- Hiltunen JK, Schonauer MS, Autio KJ, Mittelmeier TM, Kastaniotis AJ, Dieckmann CL; ''Mitochondrial fatty acid synthesis type II: more than just fatty acids.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
- Kakeru Yokoi, Masatsugu Hatakeyama, Seigo Kuwazaki, Taro Maeda, Mikio Yoshiyama, Mari Horigane-Ogihara, Shigeru Matsuyama, Akiya Jouraku, Hidemasa Bono, Kiyoshi Kimura; ''Comprehensive expression data for two honey bee species, Apis mellifera and Apis cerana japonica''; Scientific Data, 2025 DOI Scholia
- Liu TC, Kim H, Arizmendi C, Kitano A, Patel MS; ''Identification of two missense mutations in a dihydrolipoamide dehydrogenase-deficient patient.''; Proc Natl Acad Sci U S A, 1993 PubMed Europe PMC Scholia
- Des Rosiers C, Fernandez CA, David F, Brunengraber H; ''Reversibility of the mitochondrial isocitrate dehydrogenase reaction in the perfused rat liver. Evidence from isotopomer analysis of citric acid cycle intermediates.''; J Biol Chem, 1994 PubMed Europe PMC Scholia
- Des Rosiers C, Di Donato L, Comte B, Laplante A, Marcoux C, David F, Fernandez CA, Brunengraber H; ''Isotopomer analysis of citric acid cycle and gluconeogenesis in rat liver. Reversibility of isocitrate dehydrogenase and involvement of ATP-citrate lyase in gluconeogenesis.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
- Sheu KF, Blass JP; ''The alpha-ketoglutarate dehydrogenase complex.''; Ann N Y Acad Sci, 1999 PubMed Europe PMC Scholia
- Comte B, Vincent G, Bouchard B, Benderdour M, Des Rosiers C; ''Reverse flux through cardiac NADP(+)-isocitrate dehydrogenase under normoxia and ischemia.''; Am J Physiol Heart Circ Physiol, 2002 PubMed Europe PMC Scholia
- Fernandez CA, Des Rosiers C; ''Modeling of liver citric acid cycle and gluconeogenesis based on 13C mass isotopomer distribution analysis of intermediates.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
- Krebs HA, Holzach O; ''The conversion of citrate into cis-aconitate and isocitrate in the presence of aconitase.''; Biochem J, 1952 PubMed Europe PMC Scholia
- Johnson JD, Muhonen WW, Lambeth DO; ''Characterization of the ATP- and GTP-specific succinyl-CoA synthetases in pigeon. The enzymes incorporate the same alpha-subunit.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
- Lambeth DO, Tews KN, Adkins S, Frohlich D, Milavetz BI; ''Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
- Hoek JB, Rydström J; ''Physiological roles of nicotinamide nucleotide transhydrogenase.''; Biochem J, 1988 PubMed Europe PMC Scholia
- Sazanov LA, Jackson JB; ''Proton-translocating transhydrogenase and NAD- and NADP-linked isocitrate dehydrogenases operate in a substrate cycle which contributes to fine regulation of the tricarboxylic acid cycle activity in mitochondria.''; FEBS Lett, 1994 PubMed Europe PMC Scholia
History
External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| 3-Hydroxyacyl-ACP | Metabolite | CHEBI:57318 (ChEBI)  | |
| 3-Ketoacyl-ACP | Metabolite | CHEBI:57347 (ChEBI) | |
| ACACA | GeneProduct | STRG.2776.2 (Other) | |
| ACACA | GeneProduct | STRG.2776.7 (Other) | |
| ATP | Metabolite | HMDB0000538 (HMDB) | The ChEBI ID with the correct charge is: 30616 |
| Acetyl-CoA | Metabolite | HMDB0001206 (HMDB) | The ChEBI ID with the correct charge is: 57288 |
| Acetyl/Acyl-ACP | Metabolite | Q59811305 (Wikidata) | |
| Acyl-ACP | Metabolite | ||
| CO₂ | Metabolite | HMDB0001967 (HMDB) | |
| H | Metabolite | CHEBI:15378 (ChEBI) | |
| HSD17B12 | GeneProduct | STRG.6101.2 (Other) | |
| HSD17B12 | GeneProduct | STRG.817.1 (Other) | |
| HSD17B12 | GeneProduct | STRG.817.2 (Other) | |
| HSD17B12 | GeneProduct | STRG.817.3 (Other) | |
| HTD2 | GeneProduct | STRG.9051.11 (Other) | |
| KAS | GeneProduct | STRG.10815.2 (Other) | |
| MCAT | GeneProduct | g183.t1 (Other) | |
| MECR | GeneProduct | STRG.7874.5 (Other) | |
| Malonyl-ACP | Metabolite | C01209 (KEGG Compound) | |
| Malonyl-CoA | Metabolite | HMDB0001175 (HMDB) | |
| Medium/Long-chain fatty acids | Metabolite | ||
| NADPH | Metabolite | HMDB0000221 (HMDB) | The ChEBI ID with the correct charge is: 57783 |
| NADP | Metabolite | HMDB0000217 (HMDB) | |
| Octanoyl-ACP | Metabolite | CHEBI:7725 (ChEBI) | |
| Trans-2-enoyl-ACP | Metabolite | C05748 (KEGG Compound) | |
| water | Metabolite | HMDB0002111 (HMDB) |
Annotated Interactions
No annotated interactions
