Nucleotide metabolism (Homo sapiens)

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Description

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Ontology Terms

Bibliography

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History

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Compare	Revision	Action	Time	User	Comment
	140227	view	06:33, 8 August 2025	Egonw	Updated description
	140222	view	22:17, 7 August 2025	Khanspers	added one xref
	140221	view	22:15, 7 August 2025	Khanspers	Layout
	126434	view	10:13, 28 April 2023	Egonw	License is CCZero
	124903	view	07:11, 31 December 2022	Egonw	Converted labels to data nodes
	116530	view	11:50, 7 May 2021	Eweitz	Modified title
	107158	view	14:24, 17 September 2019	MaintBot	ChEBI identifier normalization
	106774	view	13:25, 17 September 2019	MaintBot	HMDB identifier normalization
	106576	view	21:22, 6 September 2019	Khanspers	Modified description
	105762	view	19:33, 15 August 2019	Khanspers	Modified description
	68960	view	17:39, 8 July 2013	MaintBot	Updated to 2013 gpml schema
	45328	view	20:14, 7 October 2011	Khanspers	Ontology Term : 'PW:0000012' removed !
	45327	view	20:14, 7 October 2011	Khanspers	Ontology Term : 'purine metabolic pathway' added !
	45326	view	20:14, 7 October 2011	Khanspers	Ontology Term : 'nucleotide metabolic pathway' added !
	41126	view	23:37, 1 March 2011	MaintBot	Removed redundant pathway information and comments
	38837	view	17:22, 24 September 2010	Khanspers
	38782	view	00:19, 24 September 2010	Khanspers	Changed line types
	35286	view	22:50, 11 February 2010	Mjh	Modified description
	32995	view	19:01, 30 September 2009	MaintBot	changed unknowns to metabolites
	32423	view	17:09, 15 August 2009	MaintBot	Fixed text labels
	32082	view	13:39, 14 August 2009	MaintBot	Fixed group labels
	21532	view	11:32, 14 November 2008	MaintBot	[[Pathway:Homo sapiens:Nucleotide Metabolism]] moved to [[Pathway:WP404]]: Moved to stable identifier
	14016	view	18:02, 20 May 2008	Thomas	added RRM2/RRM2B alternative route
	14013	view	17:47, 20 May 2008	Thomas	added some metabolites and connected lines
	14011	view	17:41, 20 May 2008	Thomas	Periodical save, work in progress
	13100	view	11:15, 17 May 2008	MaintBot	automated metabolite conversion
	11557	view	01:30, 11 April 2008	Txr24	RNR substrate, subunit and product fix
	8302	view	13:46, 7 January 2008	MaintBot	[[Pathway:Human:Nucleotide Metabolism]] moved to [[Pathway:Homo sapiens:Nucleotide Metabolism]]: Renaming species
	7771	view	16:16, 18 December 2007	MaintBot	fixed category names
	7384	view	12:42, 4 November 2007	MaintBot	Added categories to GPML
	6358	view	22:18, 22 May 2007	N.Fidelman	gpml file for [[Human:Nucleotide_Metabolism]]

External references

DataNodes

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Name	Type	Database reference	Comment
ADSL	GeneProduct	158 (Entrez Gene)
ADSS	GeneProduct	159 (Entrez Gene)
AICAR	Unknown	3031-94-5 (CAS)
AMP	Metabolite	HMDB03540 (HMDB)
Adenine	Unknown	73-24-5 (CAS)
Adenylosuccinate	Metabolite	15919 (ChEBI)
DHFR	GeneProduct	1719 (Entrez Gene)
GMP	Unknown	85-32-5 (CAS)
Guanine	Unknown	73-40-5 (CAS)
HPRT1	GeneProduct	3251 (Entrez Gene)
Hypoxanthine	Unknown	68-94-0 (CAS)
IMP	Metabolite	17202 (ChEBI)
IMPDH1	GeneProduct	3614 (Entrez Gene)
MTHFD2	GeneProduct	10797 (Entrez Gene)
NME2	GeneProduct	4831 (Entrez Gene)
OAZ1	GeneProduct	4946 (Entrez Gene)
Ornithine	Unknown	70-26-8 (CAS)
POLA	GeneProduct	5422 (Entrez Gene)
POLB	GeneProduct	5423 (Entrez Gene)
POLD1	GeneProduct	5424 (Entrez Gene)
POLG	GeneProduct	5428 (Entrez Gene)
PRPP	Unknown	97-55-2 (CAS)
PRPS1	GeneProduct	5631 (Entrez Gene)	Mouse: AA110812
PRPS2	GeneProduct	5634 (Entrez Gene)
Putrescine	Unknown	110-60-1 (CAS)
RRM1	GeneProduct	6240 (Entrez Gene)
RRM2	GeneProduct	6241 (Entrez Gene)
RRM2B	GeneProduct	50484 (Entrez Gene)
Ribose	Unknown	50-69-1 (CAS)
SAICAR	Unknown	3031-95-6 (CAS)
SAT	GeneProduct	6303 (Entrez Gene)
SRM	GeneProduct	6723 (Entrez Gene)
Spermidine	Unknown	124-20-9 (CAS)
Spermine	Unknown	71-44-3 (CAS)
Uric Acid	Unknown	69-93-2 (CAS)
Xanthine monophosphate	Unknown	69-89-6 (CAS)

Annotated Interactions

No annotated interactions