TGF-beta signaling pathway (Bos taurus)

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NU -> CYCYControlPlasma membraneProteins in a complex interactionReaction through unknown mechanisms/moleculesNUCYGlycosylationCYNUEndoplasmic reticulumMolecule in the pathwayECNUDNUCYNUAutophosphorylationMTSumoylationNucleusNUNUCYCYUbiquitinationGO(Protein-protein interaction)PalmitoylationCytoplasmCYCYDephosphorylationActivationCYDeubiquitinationCYMethylationDemethylationNUCYCYCYCYCYNUNUNUCYNUCYCYTranslocationCYReceptorNULigandNUInhibitionNUExtracellularNUCYPhosphorylationAcetylationNUCYGlycosylationProteolytic cleavageNUCYENCYNUMitochondriaNU -> CYDeacetylationDesumoylationNUEnzyme complexGolgi apparatusAccession Number: NetPath 7; cellmap:7NURecruitmentNUEndosomeCYNUPMCYCYCYNUNUMolecular associationNUNUERHDAC1CTCFDVL1ENGSMAD3CITED1CDK6DAB2TGFBR2YAP1TFDP2TGFB3ATF3CDK4Gene SymbolRBL2SNX4JUNBPIAS2ROCK1PIAS1TGFBR1SMURF2SMAD3BTRCTGFBR2SMURF1TGFBR3E2F5TFDP1CUL1RBL2GIPC1TGFBR2JUNSTRAPANAPC5HOXA9SKILCDC23NUP214NFYACAMK2DCDC16ERBB2IPSTK11SMAD4STAMBPL1SMURF2TFDP1NFYCSMAD3AXIN1TGFBR2SMAD7RBL1EIF3IPIK3R2PRKCDTGFB1STK11IPMAP2K6CAMK2GSMAD3FOSRBL1TRAP1PRKAR1BRBX1EP300SMAD3STRAPE2F5AXIN2TGFBR2TGFBR3SMAD7RB1CAMK2AE2F5TGFBR2FNTACAMK2BTFDP2CAV1E2F4AP2B1SPARCCDC25AMAPK14RBX1SMAD3SMAD2ANAPC10TGFB2ANAPC1MAP2K3CDC23FZR1ANAPC10ZFHX1BSMAD4MAP3K7RBL1TP53PARD3SMAD2TGFB1SMAD4UBE2D1EID2MYCSMAD4NFYBANAPC4HSPA8SNW1KPNB1TP73ACVRL1RBL1HNF4AKPNB1SNX6ANAPC5TGFBR3CDKN1ASMURF1ANAPC1CDC27TGFBR3LEF1ARRB2TGFB1SDC2TGFB2E2F5ANAPC4SNX2TGFBR1ANAPC7E2F5PRKCBE2F4ATF2FOSBVDRTGFBR1TGFB2ROCK1DAXXMEF2CMAPK14PRKCGLOC511264TGFB3ESR1RUNX2CCNE1NUP153SNIP1FOXO4TGFBR2ZFYVE9MEF2AFOXO3TGFBR2CUL1SNX6SMAD3E2F4TFDP2CCNB2ANAPC7RB1RBL1MAP3K7IP1RB1FOXH1FKBP1ABTRCFOXG1TGFBR1PPP2R2ATGFBR2PIK3R1CDC27TGFB3NCOA1SMAD2CDK2ZEB1RBX1CDC2CDC16LOC100139910SMAD3SKIUBE2D2SNX1SMAD4ESR1CDC27LOC506618CUL1XPO1SMAD3DCP1ACD44E2F4ANAPC2TGFBR2SUMO1CCND1LOC511264TGFB1DCP1AMAPK8E2F4TGFBR3SMAD7ETS1UBE2D3SP1SMAD6HGSSMAD4TGFB3E2F4ANAPC2COPS5MAPK8TGIF1CREBBPSMAD2KAT2BTGFBR3TFDP1JUNDE2F5ARCTNNB1


Description

No description

Comments

GenMAPP notes 
NetPath 7; cellmap:7 - TGF-beta Receptor Signaling Pathway

The TGF-beta Receptor Signaling pathway was kindly reviewed by Van Le Hong, Wei He and other members of Joan Massague’s lab. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP366(r21445) with a 88% conversion rate.

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Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134490view05:07, 22 July 2024EgonwAdded two gene identifiers
134192view18:21, 16 July 2024EgonwRemoved template comments
117635view11:46, 21 May 2021EweitzModified title
115903view09:17, 20 March 2021EgonwCopied the NetPath paper into the literature list
115901view08:40, 20 March 2021EgonwModified description
113971view05:58, 14 December 2020EgonwModified title
90030view19:38, 8 October 2016AlexanderPicoModified description
87359view09:35, 22 July 2016MkutmonModified description
87358view09:35, 22 July 2016MkutmonModified description
87357view09:32, 22 July 2016MaintBotadded missing graphids
84565view11:36, 3 March 2016MkutmonReverted to version '15:24, 30 June 2015' by Mkutmon
84564view11:35, 3 March 2016Mkutmonadded missing graph ids
80745view15:24, 30 June 2015Mkutmonhomology conversion
63366view22:23, 9 May 2013MaintBotUpdated to 2013 gpml schema
40538view19:30, 1 March 2011MaintBotRemoved redundant pathway information and comments
33779view00:08, 9 December 2009MaintBotAutomatic update of empty xrefs
32510view12:51, 17 August 2009MaintBotFixed text labels
31208view19:36, 13 August 2009MaintBotFixed text labels
30614view22:19, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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UBE2D3GeneProduct
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ZFHX1BGeneProduct
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Annotated Interactions

No annotated interactions
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