Ovarian Infertility Genes (Canis familiaris)

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CytoplasmNucleusOocyteOoplasmGranulosa CellNucleusMSH5Fig-alphaCYP19CDK4ZP2GDF9ZP3CCND2ESR2NR5A1NCOR1NRIP1FSHREGR1INHAPRLRSYNE2VDRCEBPBSMPD1SMAD3SMPD1PTGER2DAZLDMC1ATMCDKN1BGJA4GJA4MLH1ZP3BMPR1BTF2DLHCGRPGR


Description

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Comments

GenMAPP notes 
Ovarian ’bottleneck’ genes associated with infertility

A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility phenotypes. The individual gene pages in the OKdb (Ovarian Kaleidoscope Database: http://ovary.stanford.edu) contain information on associated fertility phenotypes sorted by ovarian and nonovarian defects and by subfertility or infertility. If one searches for null mutations (under ’mutation type’) causing infertility (’infertile - ovarian defect’, under ’female fertility status’) in mice (under ’species’), 44 gene entries are found. The expression of these infertility genes in the oocyte and granulosa cells together with their cellular localization is presented in Ovarian Infertility gene map. The theca cell genes are not presented because most publications emphasize granulosa cell studies.

GenMAPP remarks 
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HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP34(r20749) with a 88% conversion rate.

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History

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CompareRevisionActionTimeUserComment
59542view17:15, 1 March 2013MaintBotDeleted pathway: Human pw
40700view21:51, 1 March 2011MaintBotRemoved redundant pathway information and comments
33982view18:32, 9 December 2009MaintBotAutomatic update of empty xrefs
31746view12:01, 14 August 2009MaintBotFixed group labels
30689view22:46, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ATMGeneProduct479450 (Entrez Gene)
BMPR1BGeneProduct478484 (Entrez Gene)
CCND2GeneProduct611782 (Entrez Gene)
CDK4GeneProduct481131 (Entrez Gene)
CDKN1BGeneProduct403429 (Entrez Gene)
CEBPBGeneProduct
CYP19GeneProduct494003 (Entrez Gene)
DAZLGeneProduct477055 (Entrez Gene)
DMC1GeneProduct608268 (Entrez Gene)
EGR1GeneProduct481528 (Entrez Gene)
ESR2GeneProduct403639 (Entrez Gene)
FSHRGeneProduct481367 (Entrez Gene)
Fig-alphaGeneProduct
GDF9GeneProduct
GJA4GeneProduct482485 (Entrez Gene)
INHAGeneProduct488540 (Entrez Gene)
LHCGRGeneProduct481365 (Entrez Gene)
MLH1GeneProduct477019 (Entrez Gene)
MSH5GeneProduct474848 (Entrez Gene)
NCOR1GeneProduct479515 (Entrez Gene)
NR5A1GeneProduct609642 (Entrez Gene)
NRIP1GeneProduct478385 (Entrez Gene)
PGRGeneProduct403621 (Entrez Gene)
PRLRGeneProduct479363 (Entrez Gene)
PTGER2GeneProduct403797 (Entrez Gene)
SMAD3GeneProduct610902 (Entrez Gene)
SMPD1GeneProduct485334 (Entrez Gene)
SYNE2GeneProduct490729 (Entrez Gene)
TF2DGeneProduct
VDRGeneProduct486588 (Entrez Gene)
ZP2GeneProduct403988 (Entrez Gene)
ZP3GeneProduct403894 (Entrez Gene)

Annotated Interactions

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