Folic acid network (Canis familiaris)

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2025285324246, 262211781, 141918, 292115BInfluence on expressionTBTGeneric enzymeBBNegative effectBReactionBindingIEBNucleotide biosynthesisSynthesis of cholineMain functionsBBBTransformationBFormation of methionineTFormation of HemeCompetitionBBBBBBBBTTBBInterconversionConversionTransportMETABOLITEBTINORGANIC IONBINTRACELULARUnspecified interactionBBTBBTCNTUnspecified effectPositive effectBBPLASMA15-HETESOD1CopperMethionine2-Ketobutyric acidL-Glutamic acidManganeseGlycineSEPW1GPX 6GlycineFADS2PGG3MTHFRThromboxane B2XDHCobalamin15-HETEFMN1PGG2Pyrodoxal-5'-phosphateLeukotriene D4ALA (n-3)PTGISPGE2SELKPyrodoxal-5'-phosphateDHA (n-3)PNPOF2-IsoprostaneLeukotriene B4PGD2ALOX5ZincPGH2GPX25,10-METHYL-THFNiacin5-HPETEEthanolamineLeukotriene D4NADPHMethionine sulfoxideTryptophanMethylmalonic acid MTRa-tocopherolLipoxin B4CBSPGI2FOLIC ACIDEndoperoxidaseGPX1C22:5 (n-6)FOLIC ACIDAA (n-6)ThioredoxinPGFSLA (n-6)AA (n-6)PGF2aa TocopherolCholineTXNRD2LA (n-6)BTromboxane A2EPA (n-3)PGF2aGSHRAscorbic acidVitamin B12Lipoxin A4SeleniumLeukotriene A4Lipoic acidKMOd5 desaturase1-MethylnicotinamidePGI2RiboflavinS-Adenosylmethionine PTGDSAdipic acid T1-methylnicotinamideGPX 3 d4 desaturaseTCN1L-Glutamic acidTRXR 3Vitamin B12Thromboxane A2DHA (n-3)GlutathioneAdipic acidCATCopperNADPHCalciumEthanolaminePGE3TTH2OLeukotrieneE4CysteineLeukotrieneE4CalciumUric acidALA (n-3)XanthineLeukotriene C4Uric acidHomocysteineAscorbic acidS-Adenosylhomocysteine NADPFADiPF2-alphaCobalaminROSHypoxanthineS-Adenosylhomocysteine Leukotriene F4IronLipoxin A45,10-METHYL-THFEPA (n-3)TXNRD1BetaineS-AdenosylmethionineHypoxanthineTHASSeleniumSerinePTGESPGH3PGE2CarnitineCOX2Leukotriene B4SerineZincL-MethionineCystathioneSEPX1Methylmalonic acidGPX 4H2O2CNLeukotriene C4PGD2BGlutathione disulfideHemeC22:5 (n-6)CysteineIronCOX1NADP2-Ketobutyric acidO2HomocysteineGlutathioneIENicotinamide271723109, 161312


Description

The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP176(r30153) with a 53% conversion rate.

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Ontology Terms

 

Bibliography

View all...
  1. Fernandes-Costa F: Metz J.; ''Vitamin B12 binders (transcobalamins) in serum.''; Crit Rev Clin Lab Sci. , 1982 PubMed Europe PMC Scholia
  2. Wilson A, Platt R, Wu Q, Leclerc D, Christensen B, Yang H, Gravel RA, Rozen R; ''A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. ''; Molecular genetics and metabolism, 1999 PubMed Europe PMC Scholia
  3. WikiPathways; ''Selenoproteins''; http://www.wikipathways.org/index.php/Pathway:Homo_sapiens:Selenoproteins
  4. Selhub J.; ''Homocysteine metabolism.''; Annu Rev Nutr. , 1999 PubMed Europe PMC Scholia
  5. Proctor PH.; ''Free radicals, uric acid, and human disease.''; Free Radic Biol Med., 1996 PubMed Europe PMC Scholia
  6. Leclerc D, Campeau E, Goyette P, Adjalla CE, Christensen B, Ross M, Eydoux P, Rosenblatt DS, Rozen R, Gravel RA.; ''Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders. ''; Hum Mol Genet. , 1996 PubMed Europe PMC Scholia
  7. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, Cirino M, Girard Y, Larue M, Rokach J.; ''Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone''; Prostaglandins., 1982 PubMed Europe PMC Scholia
  8. Hall CA; ''Transcobalamins I and II as natural transport proteins of vitamin B12. ''; The Journal of clinical investigation , 1975 PubMed Europe PMC Scholia
  9. George J, Struthers AD.; ''The role of urate and xanthine oxidase inhibitors in cardiovascular disease.''; Cardiovasc Ther., 2008 PubMed Europe PMC Scholia
  10. Morrow JD, Roberts LJ 2nd.; ''The isoprostanes. Current knowledge and directions for future research.''; Biochem Pharmacol., 1996 PubMed Europe PMC Scholia
  11. https://analysis.ingenuity.com/; ''Arachidonic Acid Metabolism''; Ingenuity sofware
  12. http://lpi.oregonstate.edu/infocenter/vitamins/vitaminB6/; ''Vitamin B 6''; Linus Paulin institute
  13. https://analysis.ingenuity.com/; ''Prostaglandin and Leukotriene Metabolism''; Ingenuity software
  14. Singh U, Devaraj S, Jialal I.; '' Vitamin E, oxidative stress, and inflammation.''; Annu Rev Nutr., 2005 PubMed Europe PMC Scholia
  15. Bandarian V, Pattridge KA, Lennon BW, Huddler DP, Matthews RG, Ludwig ML.; ''Domain alternation switches B(12)-dependent methionine synthase to the activation conformation.''; Nat Struct Biol. , 2002 PubMed Europe PMC Scholia
  16. Kryukov GV, Kumar RA, Koc A, Sun Z, Gladyshev VN.; ''Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase.''; Proc Natl Acad Sci U S A. , 2002 PubMed Europe PMC Scholia
  17. ''Food and Nutrition Board, Institute of Medicine. Vitamin B6. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Vitamin B12, Pantothenic Acid, Biotin, and Choline.''; Washington D.C.: National Academies Press, 1998
  19. Lu C, Qiu F, Zhou H, Peng Yp, Hao W, Xu J, Yuan J, Wang S, Qiang B, Xu C, Peng X.; ''Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes.''; FEBS Lett., 2006 PubMed Europe PMC Scholia
  20. http://lpi.oregonstate.edu/infocenter/vitamins/fa/; ''Folic acid''; Linus Pauling Institute
  21. Guzik TJ, Korbut R, Adamek-Guzik T.; ''Nitric oxide and superoxide in inflammation and immune regulation.''; J Physiol Pharmacol., 2003 PubMed Europe PMC Scholia
  22. Longhi RC, Fleisher LD, Tallan HH, Gaull GE.; ''Cystathionine beta-synthase deficiency: a qualitative abnormality of the deficient enzyme modified by vitamin B6 therapy.''; Pediatr Res. , 1977 PubMed Europe PMC Scholia
  23. Vladimir Kery, Loelle Poneleit, Jeffrey D. Meyer, Mark C. Manning, Jan P. Kraus; ''Binding of Pyridoxal 5'-Phosphate to the Heme Protein Human Cystathionine -Synthase''; Biochemistry. , 1998
  24. Fowler B.; ''Homocysteine: overview of biochemistry, molecular biology, and role in disease processes. ''; Semin Vasc Med, 2005 PubMed Europe PMC Scholia
  25. Ben van Ommen, Susan Fairweather-Tait, Andreas Freidig, Alwine Kardinaal, Augustin Scalbert, Suzan Wopereis; ''A network biology model of micronutrient related health''; Br J Nutr, 2008 PubMed Europe PMC Scholia
  26. Petersen Shay K, Moreau RF, Smith EJ, Hagen TM.; ''Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity.''; IUBMB Life., 2008 PubMed Europe PMC Scholia
  27. https://analysis.ingenuity.com/pa/; ''Prostaglandin and Leukotriene Metabolism''; Ingenuity software
  28. Basu S.; ''Isoprostanes: novel bioactive products of lipid peroxidation.''; Free Radic Res., 2004 PubMed Europe PMC Scholia
  29. Selhub J.; ''Homocysteine metabolism.''; Annu Rev Nutr, 1999 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
120927view19:23, 31 January 2022EgonwReplaced an old HMDB identifier with the current one
120434view16:51, 1 December 2021EgonwRemoved spaces from two pubmed identifiers
118118view10:58, 24 May 2021EweitzModified title
106063view11:57, 16 August 2019MaintBotHMDB identifier normalization
102897view10:28, 27 January 2019EgonwReplace a PubChem SID with a CID
102080view19:35, 28 November 2018EgonwRemoved whitespace in PubMed identifiers.
87512view01:51, 25 July 2016AlexanderPicoOntology Term : 'classic metabolic pathway' added !
87511view01:50, 25 July 2016AlexanderPicoOntology Term : 'folic acid deficiency pathway' added !
82694view18:08, 22 October 2015EgonwFixed a typo.
74496view15:57, 26 April 2014EgonwFixed a PubMed ID.
74164view09:50, 2 April 2014EgonwUpdated the PubChem-substance data source.
74163view09:49, 2 April 2014EgonwUpdated the PubChem-compound data source.
74162view09:47, 2 April 2014EgonwMarked two GeneProducts as such.
74158view09:35, 2 April 2014EgonwReplaced an outdated HMDB identifier with the 3.5 one.
71452view19:16, 17 October 2013MaintBotAutomated update of data sources
68508view21:52, 5 July 2013MaintBotUpdated to 2013 gpml schema
40660view21:48, 1 March 2011MaintBotRemoved redundant pathway information and comments
33952view18:21, 9 December 2009MaintBotAutomatic update of empty xrefs
33197view18:19, 5 November 2009KhanspersModified categories
32269view13:04, 15 August 2009MaintBotFixed text labels
31802view12:19, 14 August 2009MaintBotFixed group labels
31297view20:09, 13 August 2009MaintBotFixed text labels
30761view23:12, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1-MethylnicotinamideMetaboliteHMDB00699 (HMDB)
1-methylnicotinamideMetaboliteHMDB00699 (HMDB)
15-HETEMetaboliteHMDB02218 (HMDB)
2-Ketobutyric acidMetaboliteHMDB00005 (HMDB)
5,10-METHYL-THFMetaboliteHMDB01396 (HMDB)
5-HPETEMetaboliteHMDB01193 (HMDB)
AA (n-6)MetaboliteHMDB01043 (HMDB)
ALA (n-3)MetaboliteHMDB01388 (HMDB)
ALOX5Protein477753 (Entrez Gene)
Adipic acid MetaboliteHMDB00448 (HMDB)
Adipic acidMetaboliteHMDB00448 (HMDB)
Ascorbic acidMetaboliteHMDB00044 (HMDB)
BGeneProduct
BetaineMetaboliteHMDB00043 (HMDB)
C22:5 (n-6)MetaboliteHMDB01976 (HMDB)
CATProtein403474 (Entrez Gene)
CBSProtein611071 (Entrez Gene)
CNGeneProduct
COX1Protein
COX2Protein
CalciumMetaboliteHMDB00464 (HMDB)
CarnitineMetaboliteHMDB00062 (HMDB)
CholineMetaboliteHMDB00097 (HMDB)
CobalaminMetaboliteHMDB02174 (HMDB)
CopperMetaboliteHMDB00657 (HMDB)
CystathioneMetaboliteHMDB00099 (HMDB)
CysteineMetaboliteHMDB00574 (HMDB)
DHA (n-3)MetaboliteHMDB02183 (HMDB)
EPA (n-3)MetaboliteHMDB01999 (HMDB)
EndoperoxidaseProtein
EthanolamineMetaboliteHMDB00149 (HMDB)
F2-IsoprostaneMetaboliteHMDB04659 (HMDB)
FADMetabolite703 (PubChem)
FADS2Protein483792 (Entrez Gene)
FMN1Metabolite342184 (Entrez Gene)
FOLIC ACIDMetaboliteHMDB00121 (HMDB)
GPX 3 Protein
GPX 4Protein
GPX 6Protein
GPX1Protein442961 (Entrez Gene)
GPX2Protein480356 (Entrez Gene)
GSHRProteinType your comment here
Glutathione disulfideMetabolite65359 (PubChem) Type your comment here
GlutathioneMetaboliteHMDB00125 (HMDB)
GlycineMetaboliteHMDB00123 (HMDB)
H2O2MetaboliteHMDB03125 (HMDB)
H2OMetaboliteHMDB02111 (HMDB)
HemeMetaboliteHMDB03178 (HMDB)
HomocysteineMetabolite
HomocysteineMetaboliteHMDB00742 (HMDB)
HypoxanthineMetaboliteHMDB00157 (HMDB)
IEGeneProduct
IronMetaboliteHMDB00692 (HMDB)
KMOProtein480093 (Entrez Gene)
L-Glutamic acidMetaboliteHMDB00148 (HMDB)
L-MethionineMetaboliteHMDB00696 (HMDB)
LA (n-6)MetaboliteHMDB00673 (HMDB)
Leukotriene A4MetaboliteHMDB01337 (HMDB)
Leukotriene B4MetaboliteHMDB01085 (HMDB)
Leukotriene C4MetaboliteHMDB01198 (HMDB)
Leukotriene D4MetaboliteHMDB03080 (HMDB)
Leukotriene F4Metabolite
LeukotrieneE4MetaboliteHMDB02200 (HMDB)
Lipoic acidMetaboliteHMDB01451 (HMDB)
Lipoxin A4MetaboliteHMDB04385 (HMDB)
Lipoxin B4MetaboliteHMDB05082 (HMDB)
MTHFRProtein478230 (Entrez Gene)
MTRProtein479190 (Entrez Gene)
ManganeseMetaboliteHMDB01333 (HMDB)
Methionine sulfoxideMetaboliteHMDB02005 (HMDB)
MethionineMetaboliteHMDB00696 (HMDB)
Methylmalonic acid MetaboliteHMDB00202 (HMDB)
Methylmalonic acidMetaboliteHMDB00202 (HMDB)
NADPHMetaboliteHMDB00221 (HMDB)
NADPMetaboliteHMDB00217 (HMDB)
NiacinMetaboliteHMDB01406 (HMDB)
NicotinamideMetabolite7847104 (PubChem)
O2MetaboliteHMDB01377 (HMDB)
PGD2MetaboliteHMDB01403 (HMDB)
PGE2Metabolite
PGE3MetaboliteHMDB02664 (HMDB)
PGF2aMetaboliteHMDB01139 (HMDB)
PGFSProtein
PGG2MetaboliteHMDB03235 (HMDB)
PGG3Metabolite
PGH2MetaboliteHMDB01381 (HMDB)
PGH3Metabolite
PGI2Metabolite
PGI2MetaboliteHMDB01335 (HMDB)
PNPOProtein480540 (Entrez Gene)
PTGDSProtein403740 (Entrez Gene)
PTGESProtein480698 (Entrez Gene)
PTGISProtein485919 (Entrez Gene)
Pyrodoxal-5'-phosphateMetaboliteHMDB01491 (HMDB)
ROSMetabolitehttp://en.wikipedia.org/wiki/Reactive_oxygen_species
RiboflavinMetaboliteHMDB00244 (HMDB) Type your comment here
S-Adenosylhomocysteine MetaboliteHMDB00939 (HMDB)
S-Adenosylmethionine MetaboliteHMDB01185 (HMDB)
S-AdenosylmethionineMetaboliteHMDB01185 (HMDB)
SELKProtein476586 (Entrez Gene)
SEPW1Protein612109 (Entrez Gene)
SEPX1Protein611032 (Entrez Gene)
SOD1Protein403559 (Entrez Gene)
SeleniumMetaboliteHMDB01349 (HMDB)
SerineMetaboliteHMDB00187 (HMDB)
TGeneProduct
TCN1Protein612538 (Entrez Gene)
THASProtein
TRXR 3Protein
TTGeneProduct
TXNRD1Protein474536 (Entrez Gene)
TXNRD2Protein608155 (Entrez Gene)
ThioredoxinMetabolite7295 (Entrez Gene)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane B2MetaboliteHMDB03252 (HMDB)
Tromboxane A2MetaboliteHMDB01452 (HMDB)
TryptophanMetaboliteHMDB00929 (HMDB)
Uric acidMetaboliteHMDB00289 (HMDB)
Vitamin B12MetaboliteHMDB00607 (HMDB)
XDHProtein483028 (Entrez Gene)
XanthineMetaboliteHMDB00292 (HMDB)
ZincMetaboliteHMDB01303 (HMDB)
a TocopherolMetaboliteHMDB01893 (HMDB)
a-tocopherolMetaboliteHMDB01893 (HMDB)
d4 desaturaseProtein
d5 desaturaseProtein
iPF2-alphaMetaboliteHMDB04659 (HMDB)

Annotated Interactions

No annotated interactions
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