Heme biosynthesis (Rattus norvegicus)
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rate limiting step
Black - reactants
delta-aminolevulinate
succinyl-CoA + glycine
H+
delta-aminolevulinate
protoporphyrinogen IX
Fe2+
Red - side products
Fech
CO2
H2O
CO2
Alad
O2
H2O2
CO2
ALAS1
Hmbs
O2
Alas2
CoA
Cpox
coproporphyrinogen III
H2O
hydroxymethylbilane
NH3
Ppox
Uros
uroporphyrinogen III
protoporphyrin IX
Urod
H2O
protoheme
Porphobilinogen
porphobilinogen
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP561(r21860)
with a 53% conversion rate.
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Bibliography
No bibliography
History
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Compare
Revision
Action
Time
User
Comment
116978
view
10:42, 16 May 2021
Eweitz
Modified title
107007
view
13:46, 17 September 2019
MaintBot
HMDB identifier normalization
89925
view
13:34, 6 October 2016
Mkutmon
Modified description
71829
view
19:35, 18 October 2013
MaintBot
removed data source from nodes without identifier
70694
view
14:40, 28 August 2013
Egonw
Added more ChemSpider IDs for metabolites previously only available as Label.
70005
view
23:32, 11 July 2013
MaintBot
updated to 2013 schema
67336
view
10:39, 26 June 2013
Christine Chichester
Ontology Term : 'heme biosynthetic pathway' added !
41679
view
02:36, 2 March 2011
MaintBot
Removed redundant pathway information and comments
35288
view
22:50, 11 February 2010
Mills42
Modified description
34069
view
19:09, 9 December 2009
MaintBot
Automatic update of empty xrefs
33527
view
09:33, 1 December 2009
MaintBot
Removed group label
30916
view
00:32, 30 July 2009
MaintBot
Converted from Homo sapiens
20861
view
11:30, 14 November 2008
MaintBot
[[Pathway:Rattus norvegicus:Heme Biosynthesis]] moved to [[Pathway:WP86]]: Moved to stable identifier
8136
view
13:46, 7 January 2008
MaintBot
[[Pathway:Rat:Heme Biosynthesis]] moved to [[Pathway:Rattus norvegicus:Heme Biosynthesis]]: Renaming species
7689
view
16:09, 18 December 2007
MaintBot
fixed category names
7374
view
12:42, 4 November 2007
MaintBot
Added categories to GPML
6556
view
22:20, 22 May 2007
Kdahlquist
gpml file for [[Rat:Heme_Biosynthesis]]
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ALAS1
GeneProduct
Alad
GeneProduct
25374 (Entrez Gene)
Alas2
GeneProduct
25748 (Entrez Gene)
CO2
Metabolite
HMDB01967 (HMDB)
CoA
Metabolite
HMDB01423 (HMDB)
Cpox
GeneProduct
304024 (Entrez Gene)
Fech
GeneProduct
361338 (Entrez Gene)
H2O2
Metabolite
HMDB03125 (HMDB)
H2O
Metabolite
HMDB02111 (HMDB)
Hmbs
GeneProduct
25709 (Entrez Gene)
NH3
Metabolite
HMDB00051 (HMDB)
O2
Metabolite
HMDB01377 (HMDB)
Porphobilinogen
Metabolite
HMDB00245 (HMDB)
Ppox
GeneProduct
289219 (Entrez Gene)
Urod
GeneProduct
29421 (Entrez Gene)
Uros
GeneProduct
309070 (Entrez Gene)
coproporphyrinogen III
GeneProduct
hydroxymethylbilane
GeneProduct
porphobilinogen
GeneProduct
protoheme
GeneProduct
protoporphyrin IX
GeneProduct
uroporphyrinogen III
GeneProduct
Annotated Interactions
No annotated interactions
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