DNA replication (Pan troglodytes)

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Orc2Orc3Phosphorylation ofMcm 2-7 complexRFC40Mcm10Orc complexMcm75. Leading/lagging strand synthesisRFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerp70Ubiquitinated Cdc6Orc5Processive complexOrc complexRNA primer-DNA primerDNA polymerase alpha:primase: origin complexRFC38RFC Heteropentamer:RNA primer-DNA primer1. Assembly of the pre-replicative complexMcm6DNAPolymerase ARNA primer-DNA primerOrc4UbiquitinOrc3Orc2UbiquitinMcm7Mcm3p180Orc1Phosphorylated Orc1Mcm 4,6,7 trimer forms andassociates with the replication forkRFC36Cdt1Mcm4Mcm5Cdc6Mcm3Cdc6Orc5Mcm5Orc complexOrc2RFC1403. DNA replication initiationOrc3Cdt12. Activation of the pre-replicative complexPre-replicative complexMcm2Orc complexp49RNA primer-DNA primer:origin duplex:PCNAOrc2Cdc6PrimaseOriginp58Degraded by proteasome in cytosolOrc3Pre-replicative complexOrc4GemininCdc6RFC37Cdt1Mcm2RNA PrimerOrc complexCdt1Orc5Mcm6DNA polymerase alpha:primase: origin complexMcm10Phosphorylated Cdc6Degraded byproteasomein cytosol4. Switching of origins to post-replicative stateMcm4Cdt1Ubiquitinated Orc1POLEATPRFC2UTPCDK2ATPDBF4RPA4MCM5GMNNCDC45LRFC1ORC6LGTPADPRPA1UBA52ORC5LMCM4CDC6dATPPOLD4ORC2LMCM10dGTPPOLD1RFC4PCNAPRIM2APRIM1dCTPdUTPRFC3ATPMCM2ATPRFC5MCM6ORC4LPOLD2CDC7POLE2CDT1ORC1LRPA2POLA2ORC3LRPA3POLD3POLAADPMCM3UBCCTPMCM7


Description

No description

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 63% conversion rate.

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Ontology Terms

 

Bibliography

  1. Cimbora DM, Groudine M; ''The control of mammalian DNA replication: a brief history of space and timing.''; Cell, 2001 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  3. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117387view10:32, 21 May 2021EweitzModified title
71683view19:41, 17 October 2013MaintBotAutomated update of data sources
69284view18:40, 8 July 2013MaintBotUpdated to 2013 gpml schema
67166view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
41593view02:01, 2 March 2011MaintBotRemoved redundant pathway information and comments
35219view15:51, 11 February 2010Thomasadded literature
35209view15:44, 11 February 2010ThomasModified description
35205view15:42, 11 February 2010ThomasModified description
34323view22:13, 9 December 2009MaintBotAutomatic update of empty xrefs
33531view09:34, 1 December 2009MaintBotRemoved group label
31567view21:57, 13 August 2009MaintBotFixed text labels
30434view21:21, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPGeneProduct
ATPGeneProduct
CDC45LGeneProduct458651 (Entrez Gene)
CDC6GeneProduct468234 (Entrez Gene)
CDC7GeneProduct
CDK2GeneProduct467032 (Entrez Gene)
CDT1GeneProduct
CTPGeneProduct
DBF4GeneProduct472668 (Entrez Gene)
GMNNGeneProduct462477 (Entrez Gene)
GTPGeneProduct
MCM10GeneProduct450309 (Entrez Gene)
MCM2GeneProduct460668 (Entrez Gene)
MCM3GeneProduct462763 (Entrez Gene)
MCM4GeneProduct472757 (Entrez Gene)
MCM5GeneProduct458790 (Entrez Gene)
MCM6GeneProduct741695 (Entrez Gene)
MCM7GeneProduct472460 (Entrez Gene)
ORC1LGeneProduct456857 (Entrez Gene)
ORC2LGeneProduct459868 (Entrez Gene)
ORC3LGeneProduct462876 (Entrez Gene)
ORC4LGeneProduct459647 (Entrez Gene)
ORC5LGeneProduct463636 (Entrez Gene)
ORC6LGeneProduct465140 (Entrez Gene)
PCNAGeneProduct458081 (Entrez Gene)
POLAGeneProduct
POLA2GeneProduct451318 (Entrez Gene)
POLD1GeneProduct
POLD2GeneProduct472654 (Entrez Gene)
POLD3GeneProduct451422 (Entrez Gene)
POLD4GeneProduct451366 (Entrez Gene)
POLE2GeneProduct452888 (Entrez Gene)
POLEGeneProduct467165 (Entrez Gene)
PRIM1GeneProduct746924 (Entrez Gene)
PRIM2AGeneProduct
RFC1GeneProduct461174 (Entrez Gene)
RFC2GeneProduct463467 (Entrez Gene)
RFC3GeneProduct452533 (Entrez Gene)
RFC4GeneProduct
RFC5GeneProduct741099 (Entrez Gene)
RPA1GeneProduct454414 (Entrez Gene)
RPA2GeneProduct456680 (Entrez Gene)
RPA3GeneProduct472290 (Entrez Gene)
RPA4GeneProduct736976 (Entrez Gene)
UBA52GeneProduct735674 (Entrez Gene)
UBCGeneProduct
UTPGeneProduct
dATPGeneProduct
dCTPGeneProduct
dGTPGeneProduct
dUTPGeneProduct

Annotated Interactions

No annotated interactions
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