Methylation (Pan troglodytes)
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SAM synthesis (co-substrate)
O-methylation
N-methylation
S-methylation
MAT2A
O-methylated substrate
INMT
S-Adenosylmethionine
L-Methionine
Phosphate
PNMT
COMT
MAT2B
MAT1A
S-Adenosylmethionine
N-methylated substrate
S-Adenosylhomocysteine
Substrate
TPMT_PANTR
S-methylated substrate
S-Adenosylhomocysteine
Phosphate
S-Adenosylhomocysteine
NNMT
Q9N2A9_PANTR
ATP
S-Adenosylmethionine
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP704(r30265)
with a 100% conversion rate.
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Bibliography
Testa B, Kramer SD; ''The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.''; Chem Biodivers, 2008
PubMed
Europe PMC
Scholia
Weinshilboum RM; ''Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase.''; Cell Mol Neurobiol, 2006
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
118294
view
12:13, 26 May 2021
Eweitz
Modified title
106920
view
13:39, 17 September 2019
MaintBot
HMDB identifier normalization
69233
view
18:34, 8 July 2013
MaintBot
Updated to 2013 gpml schema
58901
view
04:47, 21 February 2013
MaintBot
Updated Ensembl and UniProt data source
41537
view
01:57, 2 March 2011
MaintBot
Removed redundant pathway information and comments
33538
view
09:36, 1 December 2009
MaintBot
Removed group label
30443
view
21:24, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ATP
Metabolite
HMDB00538 (HMDB)
COMT
GeneProduct
ENSPTRG00000014070 (Ensembl Chimp)
INMT
GeneProduct
ENSPTRG00000019045 (Ensembl Chimp)
L-Methionine
Metabolite
HMDB00696 (HMDB)
MAT1A
GeneProduct
ENSPTRG00000002682 (Ensembl Chimp)
MAT2A
GeneProduct
ENSPTRG00000012134 (Ensembl Chimp)
MAT2B
GeneProduct
ENSPTRG00000017504 (Ensembl Chimp)
N-methylated substrate
Metabolite
NNMT
GeneProduct
ENSPTRG00000004303 (Ensembl Chimp)
O-methylated substrate
Metabolite
PNMT
GeneProduct
ENSPTRG00000009098 (Ensembl Chimp)
Phosphate
Metabolite
HMDB01429 (HMDB)
Q9N2A9_PANTR
GeneProduct
ENSPTRG00000012503 (Ensembl Chimp)
S-Adenosylhomocysteine
Metabolite
HMDB00939 (HMDB)
S-Adenosylmethionine
Metabolite
HMDB01185 (HMDB)
S-methylated substrate
Metabolite
Substrate
Metabolite
TPMT_PANTR
GeneProduct
ENSPTRG00000017756 (Ensembl Chimp)
Annotated Interactions
No annotated interactions
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Pathway
Discussion
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