Eicosanoid synthesis (Bos taurus)
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12-Hydroperoxy Eicosatetraenoic Acid
6-Keto-Prostaglandin F2-alpha
Prostaglandin E2
Thromboxane A3
Cell Membrane
15-Hydroperoxy Eicosatetraenoic Acid
LTC4S
PTGS2
5-HETE
Prostaglandin I2
Peroxidase?
5-HPETE
12-HETE
Leukotriene C4
ALOX5
ALOX15
Arachidonic acid
PLA2G2A
Prostaglandin D2
PTGIS
GGT1
Peroxidase?
DPEP1
Peroxidase?
PTGDS
ALOX15
15-HETE
Leukotriene D4
PTGES
PTGS1
Thromboxane A2
ALOX12
PNPLA8
PLA2G6
PLA2G6
Prostaglandin F2a
Leukotriene E4
Leukotriene B4
ALOX15B
PTGES2
ALOX5AP
ALOX5AP
Thromboxane B2
Prostaglandin H2
PGE2 9-ketoreduc
LTA4H
TBXAS1
Leukotriene A4
ALOX5
PGD2 11-ketoreduc
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP167(r21031)
with a 74% conversion rate.
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Quality Tags
Ontology Terms
Saving...
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Bibliography
Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
117503
view
11:04, 21 May 2021
Eweitz
Modified title
105992
view
11:52, 16 August 2019
MaintBot
HMDB identifier normalization
89456
view
13:09, 15 September 2016
Mkutmon
remove space in ontology term id
80925
view
15:31, 30 June 2015
Mkutmon
homology conversion
78598
view
14:51, 7 January 2015
MaintBot
added missing graphIds
71397
view
19:00, 17 October 2013
MaintBot
Automated update of data sources
67188
view
10:18, 26 June 2013
Christine Chichester
Ontology Term : 'eicosanoid biosynthetic pathway' added !
63319
view
21:06, 9 May 2013
MaintBot
Updated to 2013 gpml schema
62701
view
23:16, 1 May 2013
MaintBot
Updated UniProt data source
40500
view
19:28, 1 March 2011
MaintBot
Removed redundant pathway information and comments
35481
view
12:15, 12 February 2010
Thomas
added literature
35477
view
12:13, 12 February 2010
Thomas
Modified description
33744
view
23:56, 8 December 2009
MaintBot
Automatic update of empty xrefs
33620
view
10:02, 1 December 2009
MaintBot
Removed group label
30541
view
21:56, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
12-HETE
GeneProduct
15-HETE
GeneProduct
5-HETE
GeneProduct
5-HPETE
Metabolite
HMDB01193 (HMDB)
ALOX12
GeneProduct
407169 (Entrez Gene)
ALOX15
GeneProduct
282139 (Entrez Gene)
ALOX15B
GeneProduct
286820 (Entrez Gene)
ALOX5
GeneProduct
404074 (Entrez Gene)
ALOX5AP
GeneProduct
613869 (Entrez Gene)
Arachidonic acid
Metabolite
HMDB01043 (HMDB)
DPEP1
GeneProduct
514685 (Entrez Gene)
GGT1
GeneProduct
615582 (Entrez Gene)
LTA4H
GeneProduct
507130 (Entrez Gene)
LTC4S
GeneProduct
511749 (Entrez Gene)
Leukotriene A4
Metabolite
HMDB01337 (HMDB)
Leukotriene B4
Metabolite
HMDB01085 (HMDB)
Leukotriene C4
Metabolite
HMDB01198 (HMDB)
Leukotriene D4
Metabolite
HMDB03080 (HMDB)
Leukotriene E4
Metabolite
HMDB02200 (HMDB)
PGD2 11-ketoreduc
GeneProduct
PGE2 9-ketoreduc
GeneProduct
PLA2G2A
GeneProduct
521383 (Entrez Gene)
PLA2G6
GeneProduct
535381 (Entrez Gene)
PNPLA8
GeneProduct
535496 (Entrez Gene)
PTGDS
GeneProduct
286858 (Entrez Gene)
PTGES2
GeneProduct
493639 (Entrez Gene)
PTGES
GeneProduct
282019 (Entrez Gene)
PTGIS
GeneProduct
282021 (Entrez Gene)
PTGS1
GeneProduct
282022 (Entrez Gene)
PTGS2
GeneProduct
282023 (Entrez Gene)
Peroxidase?
GeneProduct
Prostaglandin D2
Metabolite
HMDB01403 (HMDB)
Prostaglandin F2a
Metabolite
HMDB01139 (HMDB)
Prostaglandin H2
Metabolite
HMDB01381 (HMDB)
Prostaglandin I2
Metabolite
HMDB01335 (HMDB)
TBXAS1
GeneProduct
509326 (Entrez Gene)
Thromboxane A2
Metabolite
HMDB01452 (HMDB)
Thromboxane B2
Metabolite
HMDB03252 (HMDB)
Annotated Interactions
No annotated interactions
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Discussion
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