Toll-like receptor signaling pathway (Homo sapiens)

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+p(anti-viral compounds)effects+p+p+pUbiquitin mediated proteolysisCytokine-NK cell)Inflammatory cytokinesssRNAcytokine receptor+pImidazoquinolinAntiviral effectsUnmethylatedJak-STAT signaling pathwaySpecific pathwayin pDCsDegradation+p+p+pLipoproteinPPeptidoglycan(G+)(Neutrophil, immature DC,Complement andProinflammatory+CpG DNAeffectsApoptosis+pDNAcoagulation cascadesMyD88-dependent pathwayFlagellinEndosomeinteractiondsRNAMAPK signaling pathwayIKK+pLPS(G-)(Mycobacteria)Inflammatory cytokines+effects+pAutocrine / ParacrineMyD88-independent pathwayCostimulatory molecules+p(T cell)+pZymosan (Yeast)+pT cell stimulation+pLipoarabinomannanChemotacticChemotacticMAP3K7IP1MAPK10RNF41IKBKEPIK3CBTIRAPTNFIL12AIFNA10IFNA14SOCS1IL12BPIK3R3NFKB2TLR2IKBKGIFNA5AKT3MAP2K2MAPK1CASP8IFNB1IFNAR1TLR6PIK3R1MAPK14MAP2K1TOLLIPPIK3CGCCL3IRAK4MAPK12TRAF3CD40MYD88IFNB1IKBKBCD80AKT1SPP1TBK1MAP2K3MAPK8IFNA8SARM1BTKTRAF6TLR1MYD88IFNA13IFNA7RAC1NFKB1IFNB1TLR4TLR8IRF5IRAK1NFKBIATLR2PIK3CDMAPK3MAP2K7MAP2K6IRAK1RP105MAP3K7IP2FADDTICAM2IL1BTLR2sNEU1NFKB1MAPK9IFNAR2CXCL10CXCL11PIK3R2FOSMYD88IFNA1CHUKJUNMYD88sCHUKTICAM1MAP2K4SIGIRRIRF3TLR3IFNA21PIK3R5mmu-let-7eMAP3K7MAPK11STAT1ZMYND11IFNA16TIRAPIRF7PIK3CAIFNA6TRAF6LY96IFNA17IL6TRAF6LBPCXCL9CCL4CCL5TLR9TLR4sCD14IL8RELAIFNA2MAPK13AKT2TLR5MYD88IRAK4RIPK1CD86TLR7MAP3K8IFNA4


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History

CompareRevisionActionTimeUserComment
34708view18:55, 12 January 2010KhanspersDeleted pathway: duplicate
33663view18:35, 2 December 2009MisbahNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
AKT2GeneProduct208 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
AKT3GeneProduct10000 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
BTKGeneProductENSG00000010671 (Ensembl Human)
CASP8GeneProduct841 (Entrez Gene) Original kegg element: gene;87;hsa:841
CCL3GeneProduct6348 (Entrez Gene) Original kegg element: gene;44;hsa:6348
CCL4GeneProduct6351 (Entrez Gene) Original kegg element: gene;38;hsa:6351
CCL5GeneProduct6352 (Entrez Gene) Original kegg element: gene;58;hsa:6352
CD14GeneProduct929 (Entrez Gene) Original kegg element: gene;84;hsa:929
CD40GeneProduct958 (Entrez Gene) Original kegg element: gene;29;hsa:958
CD80GeneProduct941 (Entrez Gene) Original kegg element: gene;69;hsa:941
CD86GeneProduct942 (Entrez Gene) Original kegg element: gene;28;hsa:942
CHUKGeneProduct1147 (Entrez Gene) Original kegg element: gene;42;hsa:1147
CXCL10GeneProduct3627 (Entrez Gene) Original kegg element: gene;25;hsa:3627
CXCL11GeneProduct6373 (Entrez Gene) Original kegg element: gene;23;hsa:6373
CXCL9GeneProduct4283 (Entrez Gene) Original kegg element: gene;24;hsa:4283
FADDGeneProduct8772 (Entrez Gene) Original kegg element: gene;56;hsa:8772
FOSGeneProduct2353 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
IFNA10GeneProduct3446 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA13GeneProduct3447 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA1GeneProduct3439 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA14GeneProduct3448 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA16GeneProduct3449 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA17GeneProduct3451 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA21GeneProduct3452 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA2GeneProduct3440 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA4GeneProduct3441 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA5GeneProduct3442 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA6GeneProduct3443 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA7GeneProduct3444 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA8GeneProduct3445 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNAR1GeneProduct3454 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
IFNAR2GeneProduct3455 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
IFNB1GeneProduct3456 (Entrez Gene) Original kegg element: gene;1;hsa:3456
IKBKBGeneProduct3551 (Entrez Gene) Original kegg element: gene;36;hsa:3551
IKBKEGeneProduct9641 (Entrez Gene) Original kegg element: gene;54;hsa:9641
IKBKGGeneProduct8517 (Entrez Gene) Original kegg element: gene;85;hsa:8517
IL12AGeneProduct3592 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
IL12BGeneProduct3593 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
IL1BGeneProduct3553 (Entrez Gene) Original kegg element: gene;51;hsa:3553
IL6GeneProduct3569 (Entrez Gene) Original kegg element: gene;57;hsa:3569
IL8GeneProduct3576 (Entrez Gene) Original kegg element: gene;43;hsa:3576
IRAK1GeneProduct3654 (Entrez Gene) Original kegg element: gene;41;hsa:3654
IRAK4GeneProduct51135 (Entrez Gene) Original kegg element: gene;86;hsa:51135
IRF3GeneProduct3661 (Entrez Gene) Original kegg element: gene;67;hsa:3661
IRF5GeneProduct3663 (Entrez Gene) Original kegg element: gene;21;hsa:3663
IRF7GeneProduct3665 (Entrez Gene) Original kegg element: gene;20;hsa:3665
JUNGeneProduct3725 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
LBPGeneProduct3929 (Entrez Gene) Original kegg element: gene;77;hsa:3929
LY96GeneProduct23643 (Entrez Gene) Original kegg element: gene;71;hsa:23643
MAP2K1GeneProduct5604 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
MAP2K2GeneProduct5605 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
MAP2K3GeneProduct5606 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
MAP2K4GeneProduct6416 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
MAP2K6GeneProduct5608 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
MAP2K7GeneProduct5609 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
MAP3K7GeneProduct6885 (Entrez Gene) Original kegg element: gene;37;hsa:6885
MAP3K7IP1GeneProduct10454 (Entrez Gene) Original kegg element: gene;59;hsa:10454
MAP3K7IP2GeneProduct23118 (Entrez Gene) Original kegg element: gene;61;hsa:23118
MAP3K8GeneProduct1326 (Entrez Gene) Original kegg element: gene;13;hsa:1326
MAPK10GeneProduct5602 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK11GeneProduct5600 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK12GeneProduct6300 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK13GeneProduct5603 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK14GeneProduct1432 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK1GeneProduct5594 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
MAPK3GeneProduct5595 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
MAPK8GeneProduct5599 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK9GeneProduct5601 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MYD88GeneProduct4615 (Entrez Gene) Original kegg element: gene;47;hsa:4615
MYD88sGeneProductENSG00000172936 (Ensembl Human)
NEU1GeneProductENSG00000184494 (Ensembl Human)
NFKB1GeneProduct4790 (Entrez Gene) Original kegg element: gene;14;hsa:4790
NFKB2GeneProduct4791 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
NFKBIAGeneProduct4792 (Entrez Gene) Original kegg element: gene;64;hsa:4792
PIK3CAGeneProduct5290 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CBGeneProduct5291 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CDGeneProduct5293 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CGGeneProduct5294 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R1GeneProduct5295 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R2GeneProduct5296 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R3GeneProduct8503 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R5GeneProduct23533 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
RAC1GeneProduct5879 (Entrez Gene) Original kegg element: gene;48;hsa:5879
RELAGeneProduct5970 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
RIPK1GeneProduct8737 (Entrez Gene) Original kegg element: gene;17;hsa:8737
RNF41GeneProductENSG00000181852 (Ensembl Human)
RP105GeneProduct4064 (Entrez Gene)
SARM1GeneProductENSG00000004139 (Ensembl Human)
SIGIRRGeneProductENSG00000185187 (Ensembl Human)
SOCS1GeneProductENSG00000185338 (Ensembl Human)
SPP1GeneProduct6696 (Entrez Gene) Original kegg element: gene;15;hsa:6696
STAT1GeneProduct6772 (Entrez Gene) Original kegg element: gene;62;hsa:6772
TBK1GeneProduct29110 (Entrez Gene) Original kegg element: gene;52;hsa:29110
TICAM1GeneProduct148022 (Entrez Gene) Original kegg element: gene;82;hsa:148022
TICAM2GeneProduct353376 (Entrez Gene) Original kegg element: gene;80;hsa:353376
TIRAPGeneProduct114609 (Entrez Gene) Original kegg element: gene;83;hsa:114609
TLR1GeneProduct7096 (Entrez Gene) Original kegg element: gene;75;hsa:7096
TLR2GeneProduct7097 (Entrez Gene) Original kegg element: gene;74;hsa:7097
TLR2sGeneProductENSG00000137462 (Ensembl Human)
TLR3GeneProduct7098 (Entrez Gene) Original kegg element: gene;73;hsa:7098
TLR4GeneProduct7099 (Entrez Gene) Original kegg element: gene;79;hsa:7099
TLR4sGeneProductENSG00000136869 (Ensembl Human)
TLR5GeneProduct7100 (Entrez Gene) Original kegg element: gene;72;hsa:7100
TLR6GeneProduct10333 (Entrez Gene) Original kegg element: gene;76;hsa:10333
TLR7GeneProduct51284 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
TLR8GeneProduct51311 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
TLR9GeneProduct54106 (Entrez Gene) Original kegg element: gene;78;hsa:54106
TNFGeneProduct7124 (Entrez Gene) Original kegg element: gene;66;hsa:7124
TOLLIPGeneProduct54472 (Entrez Gene) Original kegg element: gene;81;hsa:54472
TRAF3GeneProduct7187 (Entrez Gene) Original kegg element: gene;16;hsa:7187
TRAF6GeneProduct7189 (Entrez Gene) Original kegg element: gene;53;hsa:7189
ZMYND11GeneProductENSG00000015171 (Ensembl Human)
mmu-let-7eGeneProduct

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1441"
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