MAPK signaling pathway (Bos taurus)

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1Phosphatidylinositolsignaling systemMAPKProliferation, differentiationMKPp38MAPKKProliferation, differentiation,inflammationProliferation, inflammation, anti-apoptosisCa2+Wnt signaling pathwayJNKERK5 pathwayDNAPTPSerum, cytotoxic drugs, irradiation,heatshock, reactive oxy speciesLPS and other stressDNA damageLPSClassical MAP kinase PathwayDAGTranscription factorsp53 signaling pathwayCycleCellDNADNADNAProliferation, differentiationDNAApoptosisIP3MAPKKKHeteromeric G-proteinMAPKKKKJNK & p38 MAP kinase pathwaySerum, EGF,reactive oxygen species.or Srk tyrokinase downstreamPTPsap1aDUSP7NTRK1CASP1MRASNR4A1HSPA8MAPK13MAPKSP1DUSP4MAPKAPK2LOC100137872CRKLmnk1/2TGFB2PAK2DAXXMAP4K3JUNDCASP9PPM1BPPP3R2MAP2K5RAC1MAPK7IKBKBRASA1FOSMAP4K4PRKCHTGFBR2PTPN7PTPN5ATF4GNA12ELK1TRAF6DUSP1PRKCDmkk3ATF2CD14TAOK1MAP2K2RPS6KA3HSPA1AMAPK8KRASPLA2G10ACVR1CcAMPMAP3K11TP53MAPTPPP3R1HSPB1TRAF2RAF1TMEM37PAK1NGFHSPB2RASGRP4MAPK4RASGRF2JUNMAP3K14AKT2MINK1GCKMAP2K4PPP3CBRASGRP1FGF4TNFTGFB3PDGFRBTAOK2PTPN5IKBKGMAP3K8EGFRCASP7fgfrBRAFCASP3IL1R2PRKACAPPP5CMAPK9MOSMAP4K1Sap1anfat2/4MAP2K6MAPK3RAP1APRKCGCRKPTPRRMAP3K7CDC42LOC100138040PLA2G5IL1R1MAP2K1RAC2MAPKAPK5PPP3CAMAP3K4IL1BMAPK1MAP2K7NLKARRB1MAP3K7IP2MAP3K6NFKB1RASA2msk1/2EGFMAP3K12NTF4HSPA5CASP6MAPK10RAP1BATF4CASP8MAP3K1MAP3K5MAP3K13IL1APTPRRSTK3PRKCBAKT1MEF2CFLNAACVR1BBDNFPRKCZFASDUSP6TGFB1MAPK8IP3DDIT3DUSP10PTPN7GRB2MEKK2/3MAXCASP2NF1LOC615374MYCMAPK14SRFPDGFBSTMN1FASLGECSITGADD45AMAPK12MAPK6PRKCDPPP3CCCDC25BTGFBR1PPM1AMAP3K7IP1LOC519251ARRB2NRASDUSP5


Description

No description

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP382(r28779) with a 83% conversion rate.

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Ontology Terms

 

Bibliography

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  1. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S; ''MAPK pathways in radiation responses.''; Oncogene, 2003 PubMed Europe PMC Scholia
  2. Tanoue T, Nishida E; ''Docking interactions in the mitogen-activated protein kinase cascades.''; Pharmacol Ther, 2002 PubMed Europe PMC Scholia
  3. Harper SJ, LoGrasso P; ''Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.''; Cell Signal, 2001 PubMed Europe PMC Scholia
  4. Yang SH, Sharrocks AD, Whitmarsh AJ; ''Transcriptional regulation by the MAP kinase signaling cascades.''; Gene, 2003 PubMed Europe PMC Scholia
  5. Takeda K, Ichijo H; ''Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.''; Genes Cells, 2002 PubMed Europe PMC Scholia
  6. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL; ''(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.''; Cell Death Differ, 2012 PubMed Europe PMC Scholia
  7. Abell AN, Granger DA, Johnson GL; ''MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  8. Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y; ''Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.''; Toxicol Lett, 2003 PubMed Europe PMC Scholia
  9. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH; ''MAP kinases.''; Chem Rev, 2001 PubMed Europe PMC Scholia
  10. Huang EJ, Reichardt LF; ''Trk receptors: roles in neuronal signal transduction.''; Annu Rev Biochem, 2003 PubMed Europe PMC Scholia
  11. Zhu X, Lee HG, Raina AK, Perry G, Smith MA; ''The role of mitogen-activated protein kinase pathways in Alzheimer's disease.''; Neurosignals, 2002 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116803view10:06, 14 May 2021EweitzModified title
111159view09:17, 21 July 2020EgonwMade more pathways clickable
107080view14:16, 17 September 2019MaintBotChEBI identifier normalization
105986view11:51, 16 August 2019MaintBotHMDB identifier normalization
105687view20:57, 13 August 2019Khanspersremoved human-specific drug targeting and mutation
96305view18:29, 7 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95777view14:31, 19 January 2018MkutmonHomology conversion update
80676view15:21, 30 June 2015Mkutmonhomology conversion
72096view21:37, 24 October 2013Mkutmonadded datasource for "Wnt signaling pathway", "Apoptosis" and "Cell cycle"
67448view11:03, 26 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
63314view21:05, 9 May 2013MaintBotUpdated to 2013 gpml schema
48136view05:54, 9 May 2012MaintBotUpdating from human to fix xref duplication
40495view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35662view22:24, 12 February 2010KhanspersAdded description and lit refs
33739view23:55, 8 December 2009MaintBotAutomatic update of empty xrefs
33639view10:06, 1 December 2009MaintBotRemoved group label
31644view22:27, 13 August 2009MaintBotFixed text labels
30567view22:05, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACVR1BGeneProduct539315 (Entrez Gene)
ACVR1CGeneProduct536380 (Entrez Gene)
AKT1GeneProduct280991 (Entrez Gene)
AKT2GeneProduct534923 (Entrez Gene)
ARRB1GeneProduct281637 (Entrez Gene)
ARRB2GeneProduct281638 (Entrez Gene)
ATF2GeneProduct509827 (Entrez Gene)
ATF4GeneProduct509107 (Entrez Gene)
BDNFGeneProduct617701 (Entrez Gene)
BRAFGeneProduct536051 (Entrez Gene)
CASP1GeneProduct514214 (Entrez Gene)
CASP2GeneProduct531419 (Entrez Gene)
CASP3GeneProduct408016 (Entrez Gene)
CASP6GeneProduct538409 (Entrez Gene)
CASP7GeneProduct526279 (Entrez Gene)
CASP8GeneProduct507481 (Entrez Gene)
CASP9GeneProduct100140945 (Entrez Gene)
CD14GeneProduct281048 (Entrez Gene)
CDC25BGeneProduct505847 (Entrez Gene)
CDC42GeneProduct532712 (Entrez Gene)
CRKGeneProduct512841 (Entrez Gene)
CRKLGeneProduct
DAXXGeneProduct504336 (Entrez Gene)
DDIT3GeneProduct777788 (Entrez Gene)
DUSP10GeneProduct541175 (Entrez Gene)
DUSP1GeneProduct539175 (Entrez Gene)
DUSP4GeneProduct540380 (Entrez Gene)
DUSP5GeneProduct507061 (Entrez Gene)
DUSP6GeneProduct515310 (Entrez Gene)
DUSP7GeneProduct785016 (Entrez Gene)
ECSITGeneProduct507245 (Entrez Gene)
EGFGeneProduct786061 (Entrez Gene)
EGFRGeneProduct407217 (Entrez Gene)
ELK1GeneProduct786886 (Entrez Gene)
FASGeneProduct282488 (Entrez Gene)
FASLGGeneProduct407111 (Entrez Gene)
FGF4GeneProduct618474 (Entrez Gene)
FLNAGeneProduct281165 (Entrez Gene)
FOSGeneProduct280795 (Entrez Gene)
GADD45AGeneProduct505463 (Entrez Gene)
GCKGeneProduct616576 (Entrez Gene)
GNA12GeneProduct515159 (Entrez Gene)
GRB2GeneProduct535298 (Entrez Gene)
HSPA1AGeneProduct282254 (Entrez Gene)
HSPA5GeneProduct415113 (Entrez Gene)
HSPA8GeneProduct281831 (Entrez Gene)
HSPB1GeneProduct516099 (Entrez Gene)
HSPB2GeneProduct508671 (Entrez Gene)
IKBKBGeneProduct281854 (Entrez Gene)
IKBKGGeneProduct281855 (Entrez Gene)
IL1AGeneProduct281250 (Entrez Gene)
IL1BGeneProduct281251 (Entrez Gene)
IL1R1GeneProduct515640 (Entrez Gene)
IL1R2GeneProduct515700 (Entrez Gene)
JUNGeneProduct280831 (Entrez Gene)
JUNDGeneProduct517192 (Entrez Gene)
KRASGeneProduct541140 (Entrez Gene)
LOC100137872GeneProduct100137872 (Entrez Gene)
LOC100138040GeneProduct100138040 (Entrez Gene)
LOC519251GeneProduct519251 (Entrez Gene)
LOC615374GeneProduct615374 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene)
MAP2K2GeneProduct510434 (Entrez Gene)
MAP2K4GeneProduct526469 (Entrez Gene)
MAP2K5GeneProduct
MAP2K6GeneProduct286883 (Entrez Gene)
MAP2K7GeneProduct787278 (Entrez Gene)
MAP3K11GeneProduct514210 (Entrez Gene)
MAP3K12GeneProduct505427 (Entrez Gene)
MAP3K13GeneProduct505369 (Entrez Gene)
MAP3K14GeneProduct508367 (Entrez Gene)
MAP3K1GeneProduct523962 (Entrez Gene)
MAP3K4GeneProduct511779 (Entrez Gene)
MAP3K5GeneProduct537380 (Entrez Gene)
MAP3K6GeneProduct614598 (Entrez Gene)
MAP3K7GeneProduct529146 (Entrez Gene)
MAP3K7IP1GeneProduct519958 (Entrez Gene)
MAP3K7IP2GeneProduct540203 (Entrez Gene)
MAP3K8GeneProduct535622 (Entrez Gene)
MAP4K1GeneProduct522002 (Entrez Gene)
MAP4K3GeneProduct507624 (Entrez Gene)
MAP4K4GeneProduct
MAPK10GeneProduct537631 (Entrez Gene)
MAPK12GeneProduct512943 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK13GeneProduct535327 (Entrez Gene)
MAPK14GeneProduct534492 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MAPK4GeneProduct529183 (Entrez Gene)
MAPK6GeneProduct538094 (Entrez Gene)
MAPK7GeneProduct537703 (Entrez Gene)
MAPK8GeneProduct539941 (Entrez Gene)
MAPK8IP3GeneProduct537598 (Entrez Gene)
MAPK9GeneProduct534125 (Entrez Gene)
MAPKAPK2GeneProduct788091 (Entrez Gene)
MAPKAPK5GeneProduct535625 (Entrez Gene)
MAPKSP1GeneProduct533155 (Entrez Gene)
MAPTGeneProduct281296 (Entrez Gene)
MAXGeneProduct540616 (Entrez Gene)
MEF2CGeneProduct512254 (Entrez Gene)
MEKK2/3GeneProduct
MINK1GeneProduct519558 (Entrez Gene)
MOSGeneProduct444869 (Entrez Gene)
MRASGeneProduct540803 (Entrez Gene)
MYCGeneProduct511077 (Entrez Gene)
NF1GeneProduct531372 (Entrez Gene)
NFKB1GeneProduct616115 (Entrez Gene)
NGFGeneProduct281350 (Entrez Gene)
NLKGeneProduct507204 (Entrez Gene)
NR4A1GeneProduct528390 (Entrez Gene)
NRASGeneProduct506322 (Entrez Gene)
NTF4GeneProduct506660 (Entrez Gene)
NTRK1GeneProduct353111 (Entrez Gene)
PAK1GeneProduct533729 (Entrez Gene)
PAK2GeneProduct
PDGFBGeneProduct540106 (Entrez Gene)
PDGFRBGeneProduct527165 (Entrez Gene)
PLA2G10GeneProduct613966 (Entrez Gene)
PLA2G5GeneProduct614911 (Entrez Gene)
PPM1AGeneProduct281994 (Entrez Gene)
PPM1BGeneProduct281995 (Entrez Gene)
PPP3CAGeneProduct286852 (Entrez Gene)
PPP3CBGeneProduct790867 (Entrez Gene)
PPP3CCGeneProduct533527 (Entrez Gene)
PPP3R1GeneProduct282321 (Entrez Gene)
PPP3R2GeneProduct617585 (Entrez Gene)
PPP5CGeneProduct510245 (Entrez Gene)
PRKACAGeneProduct282322 (Entrez Gene)
PRKCBGeneProduct282325 (Entrez Gene)
PRKCDGeneProduct505708 (Entrez Gene)
PRKCGGeneProduct282002 (Entrez Gene)
PRKCHGeneProduct518542 (Entrez Gene)
PRKCZGeneProduct286877 (Entrez Gene)
PTPN5GeneProduct615850 (Entrez Gene)
PTPN7GeneProduct614077 (Entrez Gene)
PTPRRGeneProduct536337 (Entrez Gene)
RAC1GeneProduct281440 (Entrez Gene)
RAC2GeneProduct327671 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
RAP1AGeneProduct282031 (Entrez Gene)
RAP1BGeneProduct327708 (Entrez Gene)
RASA1GeneProduct282032 (Entrez Gene)
RASA2GeneProduct533491 (Entrez Gene)
RASGRF2GeneProduct
RASGRP1GeneProduct533125 (Entrez Gene)
RASGRP4GeneProduct529375 (Entrez Gene)
RPS6KA3GeneProduct511190 (Entrez Gene)
SRFGeneProduct533039 (Entrez Gene)
STK3GeneProduct533815 (Entrez Gene)
STMN1GeneProduct616317 (Entrez Gene)
Sap1aGeneProduct
TAOK1GeneProduct536532 (Entrez Gene)
TAOK2GeneProduct533897 (Entrez Gene)
TGFB1GeneProduct282089 (Entrez Gene)
TGFB2GeneProduct534069 (Entrez Gene)
TGFB3GeneProduct538957 (Entrez Gene)
TGFBR1GeneProduct282382 (Entrez Gene)
TGFBR2GeneProduct535376 (Entrez Gene)
TMEM37GeneProduct613815 (Entrez Gene)
TNFGeneProduct280943 (Entrez Gene)
TP53GeneProduct281542 (Entrez Gene)
TRAF2GeneProduct512355 (Entrez Gene)
TRAF6GeneProduct539124 (Entrez Gene)
cAMPMetaboliteHMDB00058 (HMDB)
fgfrGeneProduct
mkk3GeneProduct
mnk1/2GeneProduct
msk1/2GeneProduct
nfat2/4GeneProduct
sap1aGeneProduct

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP998"
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