DNA replication (Bos taurus)

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Orc5OriginCdt1RFC38Mcm7Mcm10Mcm54. Switching of origins to post-replicative stateDegraded by proteasome in cytosolp58Ubiquitinated Orc1Orc3Orc complexOrc complexUbiquitinated Cdc6Orc complexRFC37Orc3Pre-replicative complexMcm4DNA polymerase alpha:primase: origin complexRNA primer-DNA primerOrc5Mcm 4,6,7 trimer forms andassociates with the replication forkOrc2Orc3DNAPolymerase AMcm5Mcm2p70Orc4RNA PrimerRFC140p180Cdt1Mcm3Mcm6Cdc6Mcm2Orc2Orc3Orc complexProcessive complexOrc4RFC402. Activation of the pre-replicative complexOrc1Cdc6RFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerPre-replicative complexPrimaseCdt15. Leading/lagging strand synthesisRNA primer-DNA primerRFC Heteropentamer:RNA primer-DNA primerUbiquitinMcm10RNA primer-DNA primer:origin duplex:PCNAp49Degraded byproteasomein cytosolOrc23. DNA replication initiationOrc5Cdt1Orc complexRFC36GemininCdt1Phosphorylation ofMcm 2-7 complexMcm6Cdc6Orc2Mcm4UbiquitinMcm7Phosphorylated Orc1DNA polymerase alpha:primase: origin complex1. Assembly of the pre-replicative complexMcm3Cdc6Phosphorylated Cdc6POLE2ADPRFC3CTPMCM10dATPPCNARPA3MCM6ORC6LRPA1RFC2ORC1LPOLA2ATPCDC7CDT1ORC2LMCM5POLD1dGTPPOLD3ORC3LMCM7dCTPPOLD4RFC5RFC1PRIM1POLA1ATPUTPRFC4ADPMCM3GTPCDK2UBA52RPA2ORC5LCDC45LDBF4PRIM2GMNNORC4LdUTPUBCPOLEPOLD2RPA4ATPMCM4CDC6ATPMCM2


Description

No description

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 69% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
129334view09:08, 27 March 2024MkutmonOntology Term : 'DNA replication pathway' added !
128701view17:08, 20 February 2024Khanspersremoved brackets and connected interactions
117497view11:03, 21 May 2021EweitzModified title
107078view14:16, 17 September 2019MaintBotChEBI identifier normalization
96303view18:26, 7 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
89896view13:12, 6 October 2016MkutmonModified description
89894view13:10, 6 October 2016MkutmonModified description
89892view13:08, 6 October 2016MkutmonReverted to version '15:28, 30 June 2015' by Mkutmon
89890view13:08, 6 October 2016MkutmonModified description
80850view15:28, 30 June 2015Mkutmonhomology conversion
71396view19:00, 17 October 2013MaintBotAutomated update of data sources
67167view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
63318view21:06, 9 May 2013MaintBotUpdated to 2013 gpml schema
40499view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35220view15:52, 11 February 2010Thomasadded literature
35208view15:43, 11 February 2010ThomasModified description
35206view15:42, 11 February 2010ThomasModified description
33743view23:56, 8 December 2009MaintBotAutomatic update of empty xrefs
33627view10:04, 1 December 2009MaintBotRemoved group label
31638view22:25, 13 August 2009MaintBotFixed text labels
30552view22:00, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite
ATPMetabolite
CDC45LGeneProduct507122 (Entrez Gene)
CDC6GeneProduct515301 (Entrez Gene)
CDC7GeneProduct516094 (Entrez Gene)
CDK2GeneProduct519217 (Entrez Gene)
CDT1GeneProduct519016 (Entrez Gene)
CTPMetabolite
DBF4GeneProduct510916 (Entrez Gene)
GMNNGeneProduct526377 (Entrez Gene)
GTPMetabolite
MCM10GeneProduct527595 (Entrez Gene)
MCM2GeneProduct510120 (Entrez Gene)
MCM3GeneProduct281302 (Entrez Gene)
MCM4GeneProduct504367 (Entrez Gene)
MCM5GeneProduct506970 (Entrez Gene)
MCM6GeneProduct517812 (Entrez Gene)
MCM7GeneProduct539924 (Entrez Gene)
ORC1LGeneProduct513523 (Entrez Gene)
ORC2LGeneProduct511281 (Entrez Gene)
ORC3LGeneProduct523714 (Entrez Gene)
ORC4LGeneProduct529245 (Entrez Gene)
ORC5LGeneProduct519409 (Entrez Gene)
ORC6LGeneProduct515476 (Entrez Gene)
PCNAGeneProduct515499 (Entrez Gene)
POLA1GeneProduct534848 (Entrez Gene)
POLA2GeneProduct514793 (Entrez Gene)
POLD1GeneProduct281990 (Entrez Gene)
POLD2GeneProduct281991 (Entrez Gene)
POLD3GeneProduct537616 (Entrez Gene)
POLD4GeneProduct617899 (Entrez Gene)
POLEGeneProduct
POLE2GeneProduct518653 (Entrez Gene)
PRIM1GeneProduct506240 (Entrez Gene)
PRIM2GeneProduct514682 (Entrez Gene)
RFC1GeneProduct
RFC2GeneProduct508652 (Entrez Gene)
RFC3GeneProduct515602 (Entrez Gene)
RFC4GeneProduct504637 (Entrez Gene)
RFC5GeneProduct508389 (Entrez Gene)
RPA1GeneProduct504844 (Entrez Gene)
RPA2GeneProduct507912 (Entrez Gene)
RPA3GeneProduct512754 (Entrez Gene)
RPA4GeneProduct
UBA52GeneProduct615199 (Entrez Gene)
UBCGeneProduct444874 (Entrez Gene)
UTPMetabolite
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP983"
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